Navigation Links
Hypertension researcher encourages colleagues to expand their focus
Date:9/14/2013

Augusta, Ga. Dr. David Pollock has a simple message for fellow hypertension researchers: think endothelin.

In a country where better than 30 percent of adults have high blood pressure and 50-75 percent of those have salt-sensitive hypertension, he believes the powerful endothelin system, which helps the body eliminate salt, should not be essentially ignored.

However, the research and clinical world focus on suppressing a better-known system, which prompts the body to hold onto salt, said Pollock, Chief of the Section of Experimental Medicine at the Medical College of Georgia at Georgia Regents University.

Pollock is giving the 2013 Lewis K. Dahl Memorial Lecture Sept. 14 during the American Heart Association's High Blood Pressure Research 2013 Scientific Sessions in New Orleans.

"If you look at blood pressure regulation and salt-controlled sodium excretion, everybody sees the renin-angiotensin-aldosterone system. That is what the books say." Pollock said. No doubt the system is important. When blood volume is low, the kidneys secret renin to make the hormone angiotensin. Angiotensin drives blood pressure up by promoting sodium retention directly and by stimulating release of aldosterone, a hormone that prompts the kidneys to resorb sodium rather than eliminate it in the urine.

It's a protective system intended to ensure that the body has enough sodium to keep blood pressure at sufficient levels to sustain life. It's also a system that's somehow dysregulated in some hypertensive patients who take ACE inhibitors or angiotensin receptor blockers to turn it down.

Since most Americans already turn down this system by eating too much salt, Pollock argues that enhancing sodium excretion might be a better approach, particularly for those not responding to existing therapies.

In fact, when an animal on a high-salt diet is given a drug to block endothelin's B receptor, blood pressure goes up 50 points
'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Second-generation drug used for hypertension aids heart function independent of blood pressure
2. OHSU study shows that a molecule critical to nerve cells increases drammatically during hypertension
3. Sodium transporter appears likely target for treating salt-sensitive hypertension
4. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
5. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
6. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
7. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
8. U of Alberta researcher steps closer to understand autoimmune diseases
9. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
10. UNH researchers find African farmers need better climate change data to improve farming practices
11. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... have found that melatonin, a naturally occurring brain substance, ... as seasonal affective disorder, or SAD. The study is ... National Academy of Science. , The study was led ... in the study of circadian (24-hour) rhythm disturbances, such ...
... and infects the most common and deadly form of brain ... devour themselves, researchers at The University of Texas M. D. ... the National Cancer Institute. , The modified adenovirus homed in ... among the cancer cells -- a process called autophagy -- ...
... the neural machinery that triggers the hungry brain to ... swings the other way after a hearty meal, as ... siesta. However, scientists have understood little about how the ... energy-related behaviors. , Now, in an article in the ...
Cached Biology News:Melatonin improves mood in winter depression 2Targeted virus compels cancer cells to eat themselves 2Targeted virus compels cancer cells to eat themselves 3New mechanism explains glucose effect on wakefulness 2New mechanism explains glucose effect on wakefulness 3
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument ... Buffers, Valves, Guages, Seals), Accessories, Services, End User ... 2019” provides a detailed overview of the major ... strategies impacting the preparative and process chromatography market ... revenue and share analysis. , Full Copy ...
(Date:12/24/2014)... Bethesda, MD (PRWEB) December 23, 2014 ... signed into law H.R. 83, the Omnibus and ... the first time, made hydrocephalus a condition eligible ... Research Programs (CDMRP) administered by the Department of ... conjunction with its allies on Capitol Hill, is ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
(Date:12/24/2014)... December 23, 2014 PharmaBoardroom,s ... out today and available for free download , digs ... change and growth in the sector today. One ... successes has been in developing a homegrown pharmaceutical manufacturing base, ... production still remains some way off. A cursory comparison with ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... America,s war on terror includes fighting the dark ... chemist Dr. Frank Raushel is helping with the fight ... chemical agent, the organophosphates. , Synthetic organophosphates started their ... their way into the dangerous alleys of chemical warfare ...
... away, but soccer aficionados can get an early start ... National Institute of Standards and Technology (NIST) and the ... summer. , Nanosoccerthe Lilliputian competition where computer-driven "nanobots" the ... no bigger than a grain of ricewill be part ...
... SAN DIEGO, Nov. 13 Gen-Probe Incorporated,(Nasdaq: GPRO ... the Lazard,Capital Markets 5th Annual Healthcare Conference on Tuesday, ... presentation is scheduled,to be webcast live and may be ... website at http://www.gen-probe.com . The webcast,will be available ...
Cached Biology Technology:Researcher working on destruction of chemical weapons 2Let the games begin! Nanosoccer at 2009 RoboCup in Austria 2Gen-Probe to Webcast Presentation at the Lazard Capital Markets 5th Annual Healthcare Conference 2
For removal of the zona pellucida. Sterile, Mouse Embryo tested...
... linear ion trap mass spectrometer enables high-throughput ... The LXQ linear ion trap mass spectrometer ... applications, delivering the fast cycle time and ... trap at an attractive price. The ...
... enables scientists who do not have access to ... have their biological samples tested for the concentration ... as 1-2-3 Chose the analytes you ... the S&S antibody menu. Send your samples ...
... 2) Dot plot, Contour plot, Density ... 4) Cell Cycle 5) Analysis ... batch generation of graphs and statistics 8) ... operations to perform complex batch analyses 10) ...
Biology Products: