Navigation Links
Hydrogen sulfide reduces glucose-induced injury in kidney cells
Date:1/3/2012

SAN ANTONIO (Jan. 3, 2012) Hydrogen sulfide, a gas notorious for its rotten-egg smell, may have redeeming qualities after all. It reduces high glucose-induced production of scarring proteins in kidney cells, researchers from The University of Texas Health Science Center San Antonio report in the Journal of Biological Chemistry. The paper is scheduled for print publication in early 2012.

Shuts down manufacture of scarring proteins

"There is interest in gases being mediators of biological events," said B.S. Kasinath, M.D., professor of medicine and a nephrologist with UT Medicine San Antonio, the clinical practice of the School of Medicine at the UT Health Science Center. "We found that when we added sodium hydrosulfide, a substance that releases hydrogen sulfide, to kidney cells exposed to high glucose, it decreased the manufacture of matrix proteins that scar the kidney."

Not as much hydrogen sulfide available in diabetic mice

Consistent with this finding, enzymes in the kidney that facilitate production of hydrogen sulfide were reduced in mice with type 1 or type 2 diabetes, Dr. Kasinath and his team reported.

Scarring in the kidney, called renal fibrosis, is a core defect leading to end-stage kidney disease. Nearly half of end-stage kidney disease in the U.S. is related to diabetes, which is a disease marked by poor regulation of blood glucose.

Potentially eliminates a problem in diabetes

"We have found a way to decrease matrix protein synthesis, which is a problem in diabetes," Dr. Kasinath said. Because the studies are limited to cells, the finding should not be extrapolated to the treatment of human diabetic kidney disease, he emphasized.

The finding paves the way for studies in mice or other animal models. Both the safety and effectiveness of hydrogen sulfide should be established in animal models of kidney disease before human trials can be considered. This precaution is required because hydrogen sulfide, at higher concentrations, is known to be a toxic agent.

Journal of Biological Chemistry editors selected the team's manuscript to be the Paper of the Week, reserved for the top 1 percent of manuscripts in significance and overall importance. About 50 to 100 papers are selected for this recognition from the more than 6,600 the journal publishes each year.

Acknowledgements

Hak Joo Lee, Ph.D., a postdoctoral fellow in the Division of Nephrology, is the lead author on the study. Dr. Kasinath, also a member of the Barshop Institute for Longevity and Aging Studies at the Health Science Center, is the senior author and wishes to acknowledge the contributions of his co-authors.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related biology news :

1. Building a sustainable hydrogen economy
2. Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
3. New metal hydride clusters provide insights into hydrogen storage
4. Breakthrough in hydrogen fuel cells
5. A chance discovery may revolutionize hydrogen production
6. Tall order sunlight-to-hydrogen system works, neutron analysis confirms
7. The effects of hydrogen on growing carbon nanotubes
8. Hydrogen fuel for thought
9. New process is promising for hydrogen fuel cell cars
10. Microbe power as a green means to hydrogen production
11. Scavenging energy waste to turn water into hydrogen fuel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions ... scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series will ... American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates ... of how to continue to feed a growing nation. At the same time, many ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... of medical marijuana products targeting the needs of consumers who are incorporating medical ... takes place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, ...
Breaking Biology Technology: