Navigation Links
Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
Date:11/21/2011

a model they have developed to study immunity to watch neutrophils move to wounds in the tails of fish larvae.

They found that hydrogen peroxide modified a protein called Lyn, and that the modification let neutrophils go to wound sites along a specific cellular pathway.

"If we blocked Lyn, it's possible cells could still get to infection sites, where they could be helpful, but not to wounds or tumors, where they could be harmful," Huttenlocher says.

The experiments showed clearly that Lyn activation was dependent on hydrogen peroxide after tissue injury, and that blocking Lyn reduced the recruitment of neutrophils to wounds. Lyn is expressed specifically in leukocytes as a sensor for hydrogen peroxide.

Lyn is also a member of a powerful class of proteins known as Src family kinases (SFKs). Many of these kinases have been identified as cellular oncogenes, or precursors to cancer.

"Lyn bridges SFKs and the new pathway we have identified, broadly linking wound healing and immunity to changes in cell behavior in cancer," says Huttenlocher. "That connection may help move us forward with a better understanding of wound healing and cancer."

Lyn's connection to hydrogen peroxide should also elevate the chemical's status from the back of the medicine cabinet to a position of much greater interest.


'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. New metal hydride clusters provide insights into hydrogen storage
2. Breakthrough in hydrogen fuel cells
3. A chance discovery may revolutionize hydrogen production
4. Tall order sunlight-to-hydrogen system works, neutron analysis confirms
5. The effects of hydrogen on growing carbon nanotubes
6. Hydrogen fuel for thought
7. New process is promising for hydrogen fuel cell cars
8. Microbe power as a green means to hydrogen production
9. Scavenging energy waste to turn water into hydrogen fuel
10. Not just bleach: Hydrogen peroxide may tell time for living cells
11. Accolade for solar-hydrogen project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Europe,s most ... Patent Office to present a video retrospective of the most exciting ... Christofer Toumazou and Sophie Wilson   ... the Award   Starting on 22 January 2015 on   ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
(Date:12/22/2014)... 22, 2014 Research and Markets ( ... "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight provides ... and fingerprinting markets. Watermarking aims to control and ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... 2013 -- American Associates, Ben-Gurion University of the Negev (AABGU) ... late Dr. Jordan Baruch, to fund stem cell research at ... The Jordan Baruch Stem Cell Research Fund was dedicated at ... Baruch and 20 members of her extended family. "Jordan ...
... new study has found that tamoxifen, a well-known breast ... mouse model of Duchenne muscular dystrophy (DMD). At present, ... the symptoms in boys with DMD, a debilitating muscular ... and cardiac impairments, paralysis, and premature death. This study ...
... TORONTO, Jan 14, 2013Taking a vitamin D supplement and drinking ... how much vitamin D is in a child,s body, new ... than even skin colour and exposure to the sun, according ... Michael,s Hospital. "Early childhood is a critical stage in ...
Cached Biology News:Ben-Gurion U. establishes stem cell research fund in honor of inventor Jordan Baruch 2Tamoxifen ameliorates symptoms of Duchenne muscular dystrophy 2Supplements and cow's milk play biggest roles in determining vitamin D levels in children 2
(Date:1/22/2015)... RI (PRWEB) January 22, 2015 Protocol ... , The growing team of brand-neutral, independent consultants, Protocol ... Philip Rogers explained that over the years, his company ... , Moroso, Town of Plainfield, as well as others. ...
(Date:1/22/2015)... January 22, 2015 zFlo Motion , ... to announce an exciting product from a new partner. ... solutions over the past 15 years, with offerings in the ... their 3D IMU system (inertial measurement unit), iSen, is opening ...
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)...   Cypher Genomics, Inc., the leading genome ... SQNM ), the leading molecular diagnostics company, today ... prenatal tests (NIPT). Through this agreement, Sequenom will ... advance analysis of clinically-relevant fetal sub-chromosomal variants detected ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... relying on existing telecommunications satellites, has put a second satellite ... weather information clients. , ,Last September, Loral Skynet ... and rerouted its customers to Telstar 5 and 6. The ... Birch, data services product manager for Weather Central, said his ...
... startups, biotech , ,Entrepreneurship, nanotechnology and biomedical engineering ... in Madison and Milwaukee, giving substance to what Wisconsin ... , , Tips for Entrepreneurs , ,Established entrepreneurs ... Entrepreneurs Conference , which runs June 1-2 at the ...
... MILWAUKEE Advocates of Windows and open-source software vied ... presentation of Wednesdays session of the ITEC conference in ... Labs , said that open-source software provides a technically ... companies that want a single, obvious place to turn ...
Cached Biology Technology:Doyles Entrepreneurs and Research week nears 2Doyles Entrepreneurs and Research week nears 3Linux and Windows duke it out at ITEC 2Linux and Windows duke it out at ITEC 3
... for high-yield protein expression ,The ... a high-yielding clone of Sf9 cells. Pre-adapted ... Cell Medium, these cells are recommended for ... baculovirus infection or transfection of appropriate vectors. ...
Mouse monoclonal antibody raised against a partial recombinant VRK2. NCBI Entrez Gene ID = VRK2...
Mouse monoclonal antibody raised against a full length recombinant SCGB3A2. NCBI Entrez Gene ID = SCGB3A2...
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Biology Products: