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Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
Date:11/21/2011

MADISON Hydrogen peroxide isn't just that bottled colorless liquid in the back of the medicine cabinet that's used occasionally for cleaning scraped knees and cut fingers.

It's also a natural chemical in the body that rallies at wound sites, jump-starting immune cells into a series of events.

A burst of hydrogen peroxide causes neutrophils, the immune system's first responders, to rush to the wound to fight microorganisms, remove damaged tissue and then start the inflammation process.

University of Wisconsin-Madison researchers now have discovered the molecular sensor that detects wound-induced hydrogen peroxide and orchestrates the marshaling of neutrophils and other immune cells, or leukocytes, including those that affect tumors.

Published in the Nov. 20, 2011, advanced online version of the journal Nature, the findings have broad implications for cancer biology as well as wound healing and the way the body fights infections.

"Our findings suggest that in the future we might be able to manipulate the new pathway we've found to make immune cells go where we want them to," says lead author Dr. Anna Huttenlocher of the UW School of Medicine and Public Health (SMPH).

A tumor is a type of unhealed wound, says Huttenlocher. Tumors and wounds both generate high levels of hydrogen peroxide, and immune cells responsible for inflammation seek out wounds as well as tumors.

But inflammatory cells can often be detrimental. The cells can contribute to a tumor's ability to grow and invade other tissue, and they can cause chronic inflammation at wound sites.

"We now speculate that the recruitment of immune cells for wound healing and tumor growth involves a different molecular pathway than recruitment of immune cells for fighting infections," says Huttenlocher, SMPH professor of pediatrics and of medical microbiology and immunology.

The researchers used transparent zebrafish larvae in
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Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

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