Navigation Links
Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
Date:11/21/2011

MADISON Hydrogen peroxide isn't just that bottled colorless liquid in the back of the medicine cabinet that's used occasionally for cleaning scraped knees and cut fingers.

It's also a natural chemical in the body that rallies at wound sites, jump-starting immune cells into a series of events.

A burst of hydrogen peroxide causes neutrophils, the immune system's first responders, to rush to the wound to fight microorganisms, remove damaged tissue and then start the inflammation process.

University of Wisconsin-Madison researchers now have discovered the molecular sensor that detects wound-induced hydrogen peroxide and orchestrates the marshaling of neutrophils and other immune cells, or leukocytes, including those that affect tumors.

Published in the Nov. 20, 2011, advanced online version of the journal Nature, the findings have broad implications for cancer biology as well as wound healing and the way the body fights infections.

"Our findings suggest that in the future we might be able to manipulate the new pathway we've found to make immune cells go where we want them to," says lead author Dr. Anna Huttenlocher of the UW School of Medicine and Public Health (SMPH).

A tumor is a type of unhealed wound, says Huttenlocher. Tumors and wounds both generate high levels of hydrogen peroxide, and immune cells responsible for inflammation seek out wounds as well as tumors.

But inflammatory cells can often be detrimental. The cells can contribute to a tumor's ability to grow and invade other tissue, and they can cause chronic inflammation at wound sites.

"We now speculate that the recruitment of immune cells for wound healing and tumor growth involves a different molecular pathway than recruitment of immune cells for fighting infections," says Huttenlocher, SMPH professor of pediatrics and of medical microbiology and immunology.

The researchers used transparent zebrafish larvae in a model they have developed to study immunity to watch neutrophils move to wounds in the tails of fish larvae.

They found that hydrogen peroxide modified a protein called Lyn, and that the modification let neutrophils go to wound sites along a specific cellular pathway.

"If we blocked Lyn, it's possible cells could still get to infection sites, where they could be helpful, but not to wounds or tumors, where they could be harmful," Huttenlocher says.

The experiments showed clearly that Lyn activation was dependent on hydrogen peroxide after tissue injury, and that blocking Lyn reduced the recruitment of neutrophils to wounds. Lyn is expressed specifically in leukocytes as a sensor for hydrogen peroxide.

Lyn is also a member of a powerful class of proteins known as Src family kinases (SFKs). Many of these kinases have been identified as cellular oncogenes, or precursors to cancer.

"Lyn bridges SFKs and the new pathway we have identified, broadly linking wound healing and immunity to changes in cell behavior in cancer," says Huttenlocher. "That connection may help move us forward with a better understanding of wound healing and cancer."

Lyn's connection to hydrogen peroxide should also elevate the chemical's status from the back of the medicine cabinet to a position of much greater interest.


'/>"/>

Contact: Dian Land
dj.land@hosp.wisc.edu
608-261-1034
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. New metal hydride clusters provide insights into hydrogen storage
2. Breakthrough in hydrogen fuel cells
3. A chance discovery may revolutionize hydrogen production
4. Tall order sunlight-to-hydrogen system works, neutron analysis confirms
5. The effects of hydrogen on growing carbon nanotubes
6. Hydrogen fuel for thought
7. New process is promising for hydrogen fuel cell cars
8. Microbe power as a green means to hydrogen production
9. Scavenging energy waste to turn water into hydrogen fuel
10. Not just bleach: Hydrogen peroxide may tell time for living cells
11. Accolade for solar-hydrogen project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent communities of ... diverse pathologies ranging from food poisoning and catheter infections to gum disease and the ... tens of billions of dollars per year, there is currently a paucity of means ...
(Date:5/23/2017)... ... May 23, 2017 , ... Customers often prefer PLC ... and again. METTLER TOLEDO has released two new videos that show how they ... of the ACT350 into Siemens and Allen Bradley PLCs is easy and fast. ...
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore ... of the Maryland Biohealth community in developing and issuing recommendations to grow Maryland's ... BioHealth Innovation Hub by 2023. , The recommendations are contained ...
(Date:5/21/2017)... ... May 19, 2017 , ... Ovation ... of the American Association of Bioanalysts (AAB) and the College of Reproductive Biology ... conference reinforces AAB’s commitment to excellence in clinical laboratory services and regulations. ...
Breaking Biology Technology: