Navigation Links
Hydrogels provide scaffolding for growth of bone cells
Date:8/16/2008

PHILADELPHIAHyaluronic hydrogels developed by Carnegie Mellon University researchers may provide a suitable scaffolding to enable bone regeneration. The hydrogels, created by Newell Washburn, Krzysztof Matyjaszewski and Jeffrey Hollinger, have proven to encourage the growth of preosteoblast cells, cells that aid the growth and development of bone. Doctoral student Sidi Bencherif will present this research, Sunday, Aug. 17 at the 236th national meeting of the American Chemical Society in Philadelphia.

Currently, physicians are able to treat patients with damaged bone tissue, like those who have bone fractures that fail to heal, using demineralized bone matrix, a biological material obtained from cadavers. Demineralized bone matrix is rich in growth factor proteins which signal bone cells in the area to multiply and form complex bone tissue, while other proteins in the matrix regulate the activity of the growth factors. Demineralized bone matrix is in limited supply, and because it comes from a human donor, there is a risk of transmitting viruses to the recipient.

"Tissue engineering is an exciting field. We're creating solutions to problems that can significantly impact people's quality of life," said Washburn, an assistant professor of chemistry and biomedical engineering at Carnegie Mellon. "These gels have great promise in not only regenerating bone, but serving as a gene therapy delivery system."

Members of the Washburn lab have been developing synthetic alternatives to demineralized bone matrix. In the work being presented today, they created a flexible hydrogel using biologically active and degradable hyaluronic acid. Hydrogels, which are considered to be the state-of-the-art in tissue design, are made from polymers that swell in water to form a gel-like material. They interact with growth factors much like demineralized bone matrix does, providing scaffolding for bone cells to proliferate and form new tissue. The researchers found that, in vitro, the hydrogels promoted cell proliferation, differentiation and mineralization of pre-osteoblast cells.

Further research by the group has created a hybrid hydrogel that incorporates a nanogel structure. This new hydrogel promotes the differentiation of cells, much like the hyaluronic acid gel while also releasing nanogels in a controlled and targeted manner. The researchers hope that this structure could be used to partner tissue engineering with gene therapy.


'/>"/>
Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-963-7274
Carnegie Mellon University
Source:Eurekalert

Related biology news :

1. NSF awards Stevens team $1 million for research on smart, bacteria-repellent nanohydrogels
2. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
3. Improved e-jet printing provides higher resolution and more versatility
4. Canada provides $1.4M for removal of hazardous trees from provincial recreation sites
5. Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management
6. Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management
7. M2SYS Technology Partners with TeraCorp Enterprises to Provide Added Security Within Check Cashing Solution
8. Study involving more than 100 scientists provides new insights on green algae
9. Shell Provides Consumers Gasoline Industrys First Pay By Touch Technology at the Pump
10. Antioxidants could provide all-purpose radiation protection
11. ESA to provide essential launch control services to EUMETSAT
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 22, 2016   Acuant , the ... solutions, has partnered with RightCrowd ® ... Visitor Management, Self-Service Kiosks and Continuous Workforce ... add functional enhancements to existing physical access ... venues with an automated ID verification and ...
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... mission to bring innovative medical technologies, services and solutions to the healthcare market. ... and implementation of various distribution, manufacturing, sales and marketing strategies that are necessary ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... , ... June 24, 2016 , ... While the majority ... as the Cary 5000 and the 6000i models are higher end machines that use ... height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
Breaking Biology Technology: