Navigation Links
Hybridization partially restores vision in cavefish, NYU study finds
Date:1/7/2008

Hybridizing blind cave fish from different cave populations can partially restore the vision of their offspring, biologists at New York University have found. The study suggests that genetic engineering can override, at least in part, half a million years of evolutionary change in one generation.

Evolution has many ways to accomplish the same end result, which in the case of cave fish is blindness, said NYU Biology Professor Richard Borowsky, the studys lead author. For this reason, the genes that are mutated in one population that lead to blindness are different in other, independently evolved populations. Thus, when you cross them, the genetic deficiencies in one lineage are compensated for by strengths in the other, and vice-versa.

The research, supported by grants from the National Science Foundation and the National Institutes of Health, appears in the most recent issue of the journal Current Biology.

The study examined four populations of blind cave fish, Astyanax mexicanus, which inhabit different caves in northeast Mexico. Blind for millennia, these fish evolved from eyed, surface fish. The researchers genetic analysis showed that the evolutionary impairment of eye development, as well as the loss of pigmentation and other cave-related changes, resulted from mutations at multiple gene sites.

In order to gauge how genetic make-up could bring about the restoration of vision, the researchers created hybrids of the different cave fish populations. Among these various hybrids, they found that nearly 40 percent in some hybrid crosses could see.

These fish are descended from ancestors that have been isolated in the dark for nearly one million years and most likely havent had the capacity for vision for at least half that time, said Borowsky. But by recombining the right genes through hybridization, you can partially restore vision. Not only are the structures of the eye restored to the point where they regain function, but all the connections to the brain for proper processing of information not used for that enormous length of time are restored.

Borowsky added that the findings could pave the way for greater understanding of human eyes.

These genes that have had their function altered by mutation are the same genes that normally play important roles in the development and maintenance of the eye in humans as well as in fishes, he explained. The cave fish system gives us an experimental model for learning about human eye development and diseases.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related biology news :

1. Twinkle after-effect can help retinal patients detect vision loss quickly and cheaply
2. UCSB researchers discover the dawn of animal vision
3. USC biomedical team to participate in $6 million low vision project
4. A unique arrangement for egg cell division
5. Study of sugars on cell surface identifies key factor in flu infection
6. Human hormone blocker found to help prevent obesity and diabetes: study
7. UVa biomedical engineering study shows magnetic field can reduce swelling
8. First-ever study to link increased mortality specifically to carbon dioxide emissions
9. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
10. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
11. Deep-sea species loss could lead to oceans collapse, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/24/2016)... NC (PRWEB) , ... June 24, 2016 , ... Researchers ... the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are ... to read it now. , Diagnostic biomarkers are signposts in the blood, lung ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology: