Navigation Links
Huntington's disease deciphered
Date:6/14/2009

Researchers at the University of Illinois at Chicago College of Medicine have discovered how the mutated huntingtin gene acts on the nervous system to create the devastation of Huntington's disease. The report of their findings is available in Nature Neuroscience online.

The researchers were able to show that the mutated huntingtin gene activates a particular enzyme, called JNK3, which is expressed only in neurons and, further, to show what effect activation of that enzyme has on neuron function.

Huntington's disease is an adult onset neurodegenerative disease marked by progressive mental and physical deterioration. It has been known for more than a decade that everyone who develops the disease has mutations in a particular gene, called huntingtin, according to Scott Brady, professor and head of anatomy and cell biology at the UIC College of Medicine.

"There are several puzzling aspects of this disease," said Brady, who is co-principal investigator on the study. "First, the mutation is there from day one. How is it that people are born with a perfectly functioning nervous system, despite the mutation, but as they grow up into their 30s and 40s they start to develop these debilitating symptoms? We need to understand why the protein is bad at 40 but it wasn't bad at 4."

The second problem, according to Brady, is that the gene is expressed not just in the nervous system but in other parts of the body. However, the only part of the body that is affected is the nervous system. Why are neurons being affected?

Brady, Gerardo Morfini, assistant professor of anatomy and cell biology at UIC and co-principal investigator of the study, and their colleagues began looking for a mechanism that could explain all the pieces of the puzzle. They found that at extremely low concentrations, huntingtin was a potent inhibitor of axonal transport, the system within the neuron that shuttles proteins from the cell body where they are
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. Gender, coupled with diabetes, affects vascular disease development
3. Study links cat disease to flame retardants in furniture and to pet food
4. Humans fostering forest-destroying disease
5. Emerging (disease) markets
6. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
7. Clemson chemists discover new way antioxidants fight debilitating diseases
8. Finding that 1-in-a-billion that could lead to disease
9. Study shows link between alcohol consumption and hiv disease progression
10. Natural chemical found in broccoli helps combat skin blistering disease
11. 60 second test could help early diagnosis of common brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... rumens and termite guts for microbes that can efficiently ... next-generation biofuels, but some of the best microbial candidates ... report. , Their study , reported in the ... is the first to use biochemical approaches to confirm ... digest fiber, breaking it down into simple sugars in ...
(Date:9/23/2014)... Pattern formation is essential in the development of animals ... how can genetic information be translated in a reliable ... , The French-flag model of stripe formation is ... by the different colours of the French flag, is ... i.e. at high, middle or low concentrations of the ...
(Date:9/23/2014)... Research and Markets  has announced the ... Opportunities, 2019" report to their offering. ... security and protection in private as well as government ... government is focusing on using biometric systems to store ... IDs that are of crucial importance to the country. ...
Breaking Biology News(10 mins):Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3Recreating the stripe patterns found in animals by engineering synthetic gene networks 2India Biometrics Market Forecast and Opportunities, 2019 2India Biometrics Market Forecast and Opportunities, 2019 3
... An improved technique for culturing cells, developed at the ... new, fundamental insights into the behavior of neuronal cells. ... a basic technique for measuring how they respond to ... tasks. Neuronal cells, which make up the central nervous ...
... "dead zone" has formed off the Oregon Coast for the ... State University. , A fundamental new trend in atmospheric and ... begun, scientists say, and apparently is expanding its scope beyond ... effect of the low-oxygen zone is also being seen in ...
... into rheumatoid arthritis (RA), a chronic inflammatory joint disease. ... RA has been linked to an inherited susceptibility. ... siblings seems to be random. , In ... patients with RA, researchers at the University of Michigan ...
Cached Biology News:Neuronal cell cultures kept on the straight and narrow 2Marine 'dead zone' off Oregon is spreading 2Marine 'dead zone' off Oregon is spreading 3New genes implicated in rheumatoid arthritis 2
(Date:9/23/2014)... ANNAPOLIS JUNCTION, MD (PRWEB) September 23, 2014 ... leader in personalized medicine, presented industry leading research and ... this past weekend at the American Academy of ... meeting took place in Phoenix, Arizona at the ... on the linkage between gender and genetic predisposition to ...
(Date:9/23/2014)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... date to $5 million. The orders are all odour control ... "We continue to see new orders coming in," said ... backlog has climbed to over $11 million." ... technology company that designs, manufactures and distributes a comprehensive line ...
(Date:9/23/2014)... , Sept. 23, 2014 News ... India devoted to genome-based research for ... Genomics (NIBMG) is taking a bite out of oral ... among males in India with the ... solutions from DataDirect Networks (DDN). , To fuel its ...
(Date:9/23/2014)... Texas (PRWEB) September 23, 2014 ... on the Global and China Isopropanol (IPA) industry. ... industry, including definitions, applications and industry chain structure. ... are provided with a focus on history, developments, ... comparison between the international and Chinese situation is ...
Breaking Biology Technology:Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 2(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 3
... a talk entitled There,s Plenty of Room at the Bottom. ... humans couldn,t manipulate atoms. However, if atomic manipulation is ... How do you know what you have done" , ... IBM and Imago have taken a seminal step along the ...
... Industrial Originally Certified ISO in January 2003 - ... Company They Audited Performed at Such a ... High Quality Level" ... Company Dedicated to Quality, IRVING, Texas, Sept. 6 Carrington,Laboratories, Inc. (Pink Sheets: ...
... Philip Young, Chief Executive Officer,of Osteologix, Inc. ... featured in an exclusive interview with http://www.wallst.net ... 6 at 11 a.m. EDT. The interview will,be ... EDT on September 6. The interview will ...
Cached Biology Technology:IBM and Imago find a crucial difficulty in semiconductor device scaling 2Carrington Reports on ISO 9001:2000 Inspection at Sabila Industrial in Costa Rica 2Carrington Reports on ISO 9001:2000 Inspection at Sabila Industrial in Costa Rica 3WallSt.net (www.wallst.net) Announces Upcoming Interview With CEO of Osteologix 2
...
Recalibration of HL-2000-CAL products...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
Several Pichia pastoris strains are available to allow you to optimize expression and recovery of your protein of interest. Table 1 provides information to help you choose the appropriate strain....
Biology Products: