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Hunting for autism's chemical clues
Date:7/9/2012

BUFFALO, N.Y. -- On her laptop computer one recent afternoon, University at Buffalo researcher Charmion Cruickshank calls up a mass spectrometry readout showing the breakdown of chemicals in the urine of a child with autism.

She has similar information for nine other children -- four with the disorder and five without -- and she has spent the past few years sifting through this puzzle of data for autism's chemical clues.

The goal of the research, led by UB chemist Troy Wood, is to pinpoint an array of molecular compounds that appear in distinct amounts in the urine of children with autism. If the team is successful, a biological test for diagnosing the disorder -- so far elusive -- could be within reach.

Such a test would provide clinicians with a more objective way of identifying autism, which is currently diagnosed by observing behavior.

"We're trying to understand, at the molecular level, how autism is occurring and manifesting itself," said Wood, an associate professor of chemistry. "A biological test for autism could assist with early diagnosis, which is critical because if you can identify children with autism early in life, the outcome is going to be better."

Pilot studies in Wood's laboratory have uncovered what may be a number of distinctive chemical traits in the urine of children with autism.

For example, compounds that appeared at depleted levels include the reduced form of glutathione -- a finding that Cruickshank, a UB PhD graduate, outlined in the dissertation she defended this May. Levels of stercobilin, another substance, also seemed abnormally low.

Deficiencies of both of these compounds are an indicator of oxidative stress, which some researchers believe plays a role in autism, Wood said.

To verify these preliminary results, which have not been published in a journal, Wood is hoping to complete a larger, validation study. Such a study would analyze 75 to 100 urine sam
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Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert  

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