Navigation Links
Hunting for autism's chemical clues
Date:7/9/2012

BUFFALO, N.Y. -- On her laptop computer one recent afternoon, University at Buffalo researcher Charmion Cruickshank calls up a mass spectrometry readout showing the breakdown of chemicals in the urine of a child with autism.

She has similar information for nine other children -- four with the disorder and five without -- and she has spent the past few years sifting through this puzzle of data for autism's chemical clues.

The goal of the research, led by UB chemist Troy Wood, is to pinpoint an array of molecular compounds that appear in distinct amounts in the urine of children with autism. If the team is successful, a biological test for diagnosing the disorder -- so far elusive -- could be within reach.

Such a test would provide clinicians with a more objective way of identifying autism, which is currently diagnosed by observing behavior.

"We're trying to understand, at the molecular level, how autism is occurring and manifesting itself," said Wood, an associate professor of chemistry. "A biological test for autism could assist with early diagnosis, which is critical because if you can identify children with autism early in life, the outcome is going to be better."

Pilot studies in Wood's laboratory have uncovered what may be a number of distinctive chemical traits in the urine of children with autism.

For example, compounds that appeared at depleted levels include the reduced form of glutathione -- a finding that Cruickshank, a UB PhD graduate, outlined in the dissertation she defended this May. Levels of stercobilin, another substance, also seemed abnormally low.

Deficiencies of both of these compounds are an indicator of oxidative stress, which some researchers believe plays a role in autism, Wood said.

To verify these preliminary results, which have not been published in a journal, Wood is hoping to complete a larger, validation study. Such a study would analyze 75 to 100 urine sam
'/>"/>

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research reveals first evidence of hunting by prehistoric Ohioans
2. Striatal brain volume predicts Huntington disease onset
3. A project to research biological and chemical aspects of microalgae to fuel approach
4. Chemical pollution in Europes seas: The monitoring must catch up with the science
5. Genzyme/ACMG Foundation Genetics Training Award in Clinical Biochemical Genetics announced
6. On the safe side: Contact-free analysis of chemical substances
7. Effect of chronic exposure to chemicals used as weapons, pesticides under study
8. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
9. Trial launched into curry chemicals cancer-fighting properties
10. Production of chemicals without petroleum
11. The first chemical circuit developed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hunting for autism's chemical clues
(Date:9/21/2014)... newborn immune T cells may have the ability to ... new study led by King,s College London. Although their ... babies may still be able to mount a strong ... Nature Medicine . , Our immune system is ... including neutrophils which play an important role in the ...
(Date:9/19/2014)... will study the unique bioelectric signaling system of the ... health. The OU researcher is working to understand ... the signals used to map the world around them. ... of 500-600 discharges a second throughout their lives. ... extreme, but necessary for survival. , "There is evidence ...
(Date:9/19/2014)... legume plants regulate their symbiotic relationship with soil ... through the plant structure from leaves into the ... in the roots. This collaborative study was conducted ... Biology, the Graduate University for Advanced Studies (SOKENDAI), ... in Japan. , Legumes, an important plant ...
Breaking Biology News(10 mins):Immune system of newborn babies is stronger than previously thought 2For legume plants, a new route from shoot to root 2
... seeps are deep-sea environments, usually a few square meters ... from the sea floor. Mud volcanoes which are active ... in the 1990s. These harsh conditions give rise to ... for life to exist on the planet. , ...
... protein crucial for the growth of brain cells during ... of long-term memories, according to researchers at UC Irvine. ... and treatments for, cognitive decline associated with normal aging ... appear in the early online edition of the Proceedings ...
... turning on a single gene, researchers can prevent skin stem ... cells -- epidermal, sebaceous and hair cells. They say this ... stem cells in the lab, for both research and potential ... which have the ability to differentiate into multiple types of ...
Cached Biology News:Life in the extreme 2Proteins necessary for brain development found to be critical for long-term memory 2Researchers identify a key regulator for skin stem cells 2
(Date:9/21/2014)... how to produce ultra-thin "diamond nanothreads" that promise extraordinary ... today,s strongest nanotubes and polymers. A paper describing this ... Badding, a professor of chemistry at Penn State University, ... of the journal Nature Materials . , "From ... because the threads we formed have a structure that ...
(Date:9/20/2014)... Texas (PRWEB) September 20, 2014 ... integrated urological and interventional radiology products and services, ... Inc. subsidiary with Clinicon Corporation for ... expands HealthTronics’ portfolio of minimally invasive, mobile, surgical ... patients. , Under the agreement, HealthTronics will make ...
(Date:9/19/2014)... disease risks, the biological characteristics people care most about ... heightthe textbook example of a complex traitattributes like risk ... genetic and environmental influences, making it challenging to find ... typically mate two individuals that differ in key waysfor ... study their descendents, looking for genes that tend to ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... its potential to revolutionize the world has attracted ... corporations and small start-ups. The early years of ... projects largely due to the high risks involved, ... budgets earmarked for this evolving technology have been ...
Breaking Biology Technology:Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4
... WILMINGTON, Del., Sept. 25 The results ... Proof Of Concept) Study of ZD4054 -- a ... today at the 14th European Congress,of Clinical Oncology ... ZD4054, an investigational compound in development for the,treatment ...
... MDVN ) today announced that it has been ... new NASDAQ(R) NeuroInsights(R) Neurotech Index.,The Index launched today and ... a total return basis (Nasdaq: NRVX.) "Medivation,s selection ... industry is testament to our commitment to and significant,clinical ...
... FRANCISCO, Sept. 25 BioSpace, the leading online,source ... the 2008 BIO,International Convention and BIOCOM, unveiled this ... Campaign. The campaign features both a,regional promotional Hotbed ... with the economic and workforce development initiatives of,Southern ...
Cached Biology Technology:Survival Data Presented From Phase II Study of Investigational Drug ZD4054 in Hormone-Resistant Prostate Cancer Patients 2Survival Data Presented From Phase II Study of Investigational Drug ZD4054 in Hormone-Resistant Prostate Cancer Patients 3Survival Data Presented From Phase II Study of Investigational Drug ZD4054 in Hormone-Resistant Prostate Cancer Patients 4Medivation Selected as Founding Member of New NASDAQ(R) NeuroInsights(R) Neurotech Index 2Medivation Selected as Founding Member of New NASDAQ(R) NeuroInsights(R) Neurotech Index 3BioSpace, 2008 BIO International Convention and BIOCOM Launch 9th Edition of Biotech Beach Hotbed Map Campaign 2
Carrier Serum...
A Highly Purified, Cost-Effective Taq DNA Polymerase...
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
... is a protein based inhibitor of nonhuman ... most common and troublesome RNases including RNase ... can be used in any application where ... ideal for in vitro transcription and translation, ...
Biology Products: