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Humans not the major target of Shiga toxin
Date:12/3/2007

ozoan predator prevented killing by Shiga toxin. Humans have the same surface receptor for Shiga toxin as do Tetrahymena, which gives biologists and produce packers a close interest in the deadly duel between Tetrahymena and Shiga-packing E. coli.

The Koudelka and Hennessey labs are continuing to characterize the route of Shiga toxin entry into the cytoplasm of Tetrahymena, its mode of killing, and the ability of Tetrahymena to develop resistance to Shiga toxin. The protozoan might make a model cellular system for Shiga detoxification, which one day might relieve some of the stress around the salad bar, say Koudelka and Hennessey.


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Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

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