Navigation Links
Humans not the major target of Shiga toxin
Date:12/3/2007

Washington, D.C. -- If youve survived Shiga toxin and the after-effects of food poisoning, you may have been the innocent victim of a battle for survival between predator and prey.

Bacteria that carry a virus (a bacteriophage) that packs the Shiga toxin gene (Stx) may depend on it for protection from bacterial predators like the ciliated protozoan Tetrahymena. This is small comfort if youve just consumed that

Food poisoning victims -- as a result, for example, of consuming Shiga-packing E.coli in a contaminated bag of spinach -- have always had the cold comfort of being told that not all common bacteria make humans extremely sick, only the strains that have integrated the Shiga gene into their DNA. These bacteria can produce large amounts of the Shiga toxin and release it into the surrounding environment.

Leaving sick humans aside for a moment, Gerald Koudelka, Todd Hennessey, and colleagues from the University at Buffalo in Amherst, New York, wondered what evolutionary advantage the bacteria would derive from carrying around such a prickly viral hitchhiker. They hypothesized that the Stx gene might give the bacterial host an equalizer against bacterial predators.

Humans may not be the major target of this toxin, explains Koudelka. Instead, they might be simply caught in the cross-fire in this ancient battle between prey and predators.

To test their hypothesis, the researchers grew Tetrahymena with an E. coli strain (EDL933) that carries the Stx gene. It worked, at least, for the EDL933 that grew successfully in co-cultures with Tetrahymena. In this hostile environment, it was the predator, Tetrahymena, that was killed by the bacterias Shiga toxin. An E. coli strain (W3110) lacking Stx did poorly with Tetrahymena as roommates. The Tetrahymena had them for lunch.

The Shiga toxin kills by binding to a receptor on the surface of Tetrahymena. Adding protein subunits that block toxin binding to the prot
'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Humans fostering forest-destroying disease
3. SRMs track fire retardants in humans and environment
4. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
5. Gene regulation in humans is closer than expected to simple organisms
6. Role reversal as humans suck life out of leeches
7. Extra gene copies were enough to make early humans mouths water
8. Newfound ancient African megadroughts may have driven the evolution of humans and fishes
9. Humans unknowing midwives for pregnant moose
10. Humans and monkeys share Machiavellian intelligence
11. University of Toronto finds humans and chimps differ at level of gene splicing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... University of Tennessee, Knoxville, research finds life can persist ... professor was part of a team that examined waters ... Antarctic ice sheet and found the extreme environment supports ... by Jill Mikucki and her colleagues has implications for ... in the solar system. The findings are published in ...
(Date:8/20/2014)... VALLEY, Calif., August 19, 2014 -- Bay Area Lyme ... diagnose and simple to cure, applauds new research published ... journal Ticks and Tick-borne Diseases . The ... Northwest California are active throughout the year, making the ... by researchers at California Department of Public Health (CDPH) ...
(Date:8/20/2014)... chili pepper causes a burning spiciness that is irresistible ... chili pepper,s effect are using their findings to develop ... which can be caused by inflammation or other problems. ... being tested in clinical trials, in ACS, Journal ... explain that decades ago, scientists had pegged a compound ...
Breaking Biology News(10 mins):University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2Lyme disease risk is year-round in Northwest California, according to new study 2Lyme disease risk is year-round in Northwest California, according to new study 3
... by LSU Associate Professors of Biological Sciences Fernando Galvez and ... and laboratory study showing the effects of the Deepwater Horizon ... , The study, funded in part by the National Science ... is being published in the journal Proceedings of the ...
... Alzheimer,s disease rises and falls in the spinal fluid in ... Washington University School of Medicine in St. Louis have found. ... and reinforces a link between increased Alzheimer,s risk and inadequate ... brain,s relative inactivity during sleep may provide an opportunity to ...
... Steve Bergens and his graduate student Jeremy Johns ... to revolutionise the chemical industry by reducing its ... Their findings were published in a top international ... the chemical industry with a potential solution to ...
Cached Biology News:LSU researchers find impact of oil spill in marsh fish species 2Marker for Alzheimer's disease rises during day and falls with sleep 2Marker for Alzheimer's disease rises during day and falls with sleep 3Catalyst discovery has potential to revolutionize chemical industry 2
(Date:8/21/2014)... Louis, MO (PRWEB) August 21, 2014 ... full service biopharmaceutical contract development and manufacturing organization ... by Progenics Pharmaceuticals, Inc., an oncology company focused ... and treating cancer, to manufacture the anti-prostate specific ... PSMA ADC product candidate. Under the agreement ...
(Date:8/20/2014)... RALEIGH, N.C. , Aug. 20, 2014 /PRNewswire/ ... clinical research services located in Raleigh, ... Bradford Evans as Vice President of ... Administration, Brad will oversee all corporate processes, including ... to joining Clintrax Global, Brad worked as an ...
(Date:8/20/2014)... time, chemists have succeeded in measuring vibrational motion of ... study reveals how vibration of a single molecule differs ... The study was performed at the University of California, ... of Jyvskyl works as a visiting fellow under professor ... The second team was lead by Professor Eric O. ...
(Date:8/20/2014)... 20, 2014  Decision Resources Group finds that the vascular access ... , India and China ... roughly equal to the size of the United States ... will experience much faster growth as a result of strong economic ... Other key findings from Decision Resources Group,s coverage of the BRIC ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Clintrax Global, Inc. Announces Addition to Executive Team 2Seeing a molecule breathe 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3
... Life Sciences,Holdings, Inc. (Nasdaq: ADLS ), ... and commercialization of novel drugs in the,therapeutic ... today,announced that it was added to the ... reconstituted its comprehensive set of U.S. and,global ...
... 3 /Xinhua-PRNewswire-FirstCall/ -- Huifeng,Bio-Pharmaceutical Technology, Inc. (OTC ... of plant extracts and pharmaceutical raw materials,for ... in China,announced today that its company information ... Market Access Program, an information distribution,service that ...
... to offer choice of two distinct drugs on ... separate drug-eluting stent platforms, NATICK, ... today announced that the U.S. Food and Drug,Administration (FDA) has ... coronary artery disease. The,PROMUS Stent is a private-labeled XIENCE(TM) V ...
Cached Biology Technology:Advanced Life Sciences Added to Russell Microcap Index 2Advanced Life Sciences Added to Russell Microcap Index 3Huifeng Bio-Pharmaceutical (HFGB) Information to Be Available Through Standard & Poor's Market Access Program 2Boston Scientific Announces FDA Approval for PROMUS(TM) Everolimus-Eluting Coronary Stent System 2Boston Scientific Announces FDA Approval for PROMUS(TM) Everolimus-Eluting Coronary Stent System 3Boston Scientific Announces FDA Approval for PROMUS(TM) Everolimus-Eluting Coronary Stent System 4
Piperazine-N',N'-bis(2-ethanesulfonic acid), monosodium salt...
... receptors constitute the principal excitatory ... classes of glutamate receptors exist: ... Ionotropic glutamate receptors are oligomeric ... NMDA1-3, KAI-2) which comprise ligand-gated ...
Recommended fro Western blotting application...
... Anti-Krueppel-like factor 15 (KLF15) KLF15 is ... found abundantly expressed in the liver, kidneys, ... NP_054798 Specificity: Polyclonal antibody produced in ... to a region of human KLF15 with ...
Biology Products: