Navigation Links
Humans and sharks share immune system feature
Date:9/30/2011

A central element of the immune system has remained constant through more than 400 million years of evolution, according to new research at National Jewish Health. In the September 29, 2011, online version of the journal Immunity, the researchers report that T-cell receptors from mice continue to function even when pieces of shark, frog and trout receptors are substituted in. The function of the chimeric receptors depends on a few crucial amino acids, found also in humans, that help the T-cell receptor bind to MHC molecules presenting antigens.

"These findings prove a hypothesis first proposed 40 years ago," said senior author Laurent Gapin, PhD, associate professor of immunology in the Integrated Deparemtn of Immunology at National Jewish Health and the University of Colorado Denver. "Even though mammals, amphibians and cartilaginous fish last shared a common ancestor more than 400 million years ago, they continue to share an element of their T-cell receptors, indicating that the T cell-MHC interaction arose early in the evolution of the immune system, and is central to its function."

The T cell serves as the sentinel, manager and enforcer of the adaptive immune response. It relies on its receptor, the T-cell receptor, to recognize foreign material and identify the target of the immune-system attack. When the receptor binds to small fragments of foreign organisms, called antigens, the T cell becomes activated, proliferates and initiates an attack against any molecule or organism containing that antigen.

T cells, however, cannot recognize free-floating antigens. They recognize antigens only when they are held by MHC molecules on the surfaces of other cells, much as a hotdog bun (MHC molecule) holds a hotdog (antigen). This interaction between the T cell and MHC molecules is crucial for immune defense and organ transplants. Compatibility of transplanted organs is determined by the similarity of different people's MHC molecules. Nonetheless, this interaction has long mystified scientists and is poorly understood.

In 1971 future Nobel Laureate Niels K. Jerne proposed that evolution might have selected for genes that specifically recognize MHC molecules. Evidence discovered later suggested T cells' affinity for MHC molecules might instead be the product of development that occurs as T cells mature in the thymus. The question remained unanswered for 40 years.

The T-cell receptor is constructed by piecing together several peptides among dozens that are available, plus a few random amino acid sequences. This combination is what allows the immune system to generate an almost infinite variety of receptors capable of recognizing almost any potential invader. The receptor has six loops that are the primary binding points for the antigen-MHC complex. One of those loops, known as CDR2, frequently binds the MHC molecule.

Searching for possible similarities in T-cell receptors of different animals, the researchers compared the amino acid sequences of one segment of the T-cell receptor containing the CDR2 loop. Although the segments contained less than 30 percent of the same amino acids, two specific amino acids were the same in human, mouse, frog, trout and shark T-cell receptors. Those appeared to be amino acids specifically involved in binding to the MHC molecule.

"The evolutionary inheritance of this pattern goes all the way from sharks to humans, which last shared a common ancestor 450 million years ago," said co-author Philippa Marrack, PhD.

The researchers then inserted segments containing the CDR2 loop from frog, trout and shark T-cell receptors into mouse cells. These chimeric T-cell receptors recognized antigen bound to a mouse MHC molecule.

Since sections of frog, trout and shark T-cell receptors functioned perfectly well in mice T-cell receptors, the experiments suggested that the T-cell's ability to see an antigen only when complexed with an MHC molecule first arose more than 400 million years ago, when all four animals shared a common ancestor.


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Related biology news :

1. New understanding of how humans and the environment interact
2. Scientists utilise breath and sweat to detect trapped humans
3. Humans naturally cooperative, altruistic, social
4. Ancient humans were mixing it up
5. Competition with humans responsible for decline of New Zealands endangered sea lions, study shows
6. Competition with humans responsible for decline of New Zealands endangered sea lions, study shows
7. New UC sensor promises rapid detection of dangerous heavy metal levels in humans
8. Aging brains are different in humans and chimpanzees
9. Evidence for food addiction in humans
10. Can humans sense the Earths magnetism?
11. Plants teach humans a thing or two about fighting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/11/2017)... Fla. , April 11, 2017 ... and secure authentication solutions, today announced that it ... Intelligence Advanced Research Projects Activity (IARPA) to develop ... Thor program. "Innovation has been a ... IARPA,s Thor program will allow us to innovate ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give ... Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. spent ... entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, 2017 ... joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, Grossmont ...
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
Breaking Biology Technology: