Navigation Links
'Humanized' mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
Date:9/10/2012

PORTLAND, Ore. A novel human liver-chimeric mouse model developed at Oregon Health & Science University and Yecuris Corporation has made possible a research breakthrough at Seattle Biomedical Research Institute that will greatly accelerate studies of the most lethal forms of human malaria.

The study findings are published online in the Journal of Clinical Investigation. Study photos were selected to appear in "Scientific Show Stoppers" on the JCI blog.

Plasmodium falciparum, one of two human-specific malaria parasites, is a global health crisis, causing more than 216 million new infections annually and resulting in an estimated 655,000 deaths, according to the World Health Organization.

Sporozoites, the infectious form of the parasite, are spread to people through the bites of infected mosquitos and multiply in the human liver during the initial stages of infection. There, they undergo liver stage development, culminating in the formation and release of tens of thousands of merozoites, the parasitic phase of development that infects red blood cells.

Until now, there have been few data on human malaria liver stage biology due to the lack of a viable small animal model and because liver stage P. falciparum does not grow well in a dish. Consequently, most research and therapeutics to date have targeted the human blood stage of P. falciparum's development because it replicates well in culture.

The liver-to-blood stage of P. falciparum is the focus of this research because the parasite is virtually harmless, causing no disease symptoms, prior to its transition to the blood stage.

In this study, researchers at Seattle Biomedical Research Institute, Yecuris Corporation, Oregon Health & Science University and The Rockefeller University have demonstrated that a complete liver-to-blood stage infection of P. falciparum is possible using a unique immunocompromised mouse model
'/>"/>

Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Mini-CT scanner developed as a teaching tool
2. Blossom end rot plummets in Purdue-developed transgenic tomato
3. The first chemical circuit developed
4. Grassroots approach to conservation developed
5. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
6. Electronic nose prototype developed
7. New long-term antimicrobial catheter developed
8. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
9. New genomic sequencing method enables smarter anaysis of individual cells
10. The end of an era? Branding horses does not enable them to be identified
11. Notre Dame researchers using novel method to combat malaria drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Humanized' mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
(Date:5/21/2015)... May 21, 2015 The Sync Project™ ... music for health, today announced a collaborative partnership with ... partnership will center on collaboration on original research, joint ... step in the collaboration, The Sync Project and BerkleeICE ... as Medicine" in the 2015-2016 academic year.  ...
(Date:5/19/2015)... 2015 Fingerprint Cards (FPC) has received ... FPC1155 and FPC1035 from one if its module partners. Deliveries ... Q3 2015 and the sensors will be used by smartphone ... for 2015 hereby amount to 740 MSEK to date. In ... MSEK and a number of smaller orders not separately communicated ...
(Date:5/18/2015)... , May 18, 2015 Fingerprint ... sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if ... June until and including Q3 2015 and the sensors will ... . Communicated order values for 2015 hereby amount to 740 ... Q1 2015 of 140 MSEK and a number of smaller ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... Helmholtz Center for Infection Research in Braunschweig, Germany and ... immune cells in a way that enables them to ... results have now been published in the current issue ... Molecular Medicine . The immune system keeps us ...
... of the first edition of the BBVA Foundation Frontiers of ... in Science back in 1975 with the title ... Global Warming?" He thus became the first person to use ... early 21st century temperatures would be climbing as a result ...
... found the existence of two types of males of a ... provide answers as to how they rapidly reproduce. ... Research , looks at the aggressive round goby, a bottom-dwelling ... Presently, they are working their way inland through rivers and ...
Cached Biology News:GARP makes the difference 2Broecker: 'What we need are tougher measures against climate change' 2Broecker: 'What we need are tougher measures against climate change' 3Not 1, but 2 kinds of males found in the invasive round goby 2
(Date:5/21/2015)... 2015 Imagine being able to ... those of others. Being able to read faces and ... people to anticipate their thoughts and actions like never ... feelings to create unique abstract paintings and video, or, ... inside a first-person-shooter as it creates action, dialog, and ...
(Date:5/21/2015)... ARIZ. (PRWEB) May 21, 2015 As ... Webb Medical Center (BDWMC), Sun Health Foundation funded a ... center’s new inpatient pharmacy with the most up-to-date features ... open June 2. The pharmacy's 45 staff members will ... larger 4,895-square-foot space in the coming days. , ...
(Date:5/21/2015)... King of Prussia, PA (PRWEB) May 21, 2015 ... that Julia O’Neill has joined the firm as senior ... more than 30 years of experience in the management ... the vaccines, biologics, pharmaceutical and chemical industries. , “We’re ... enhance our longstanding capabilities in data analytics,” said Dr. ...
(Date:5/20/2015)... , May 19, 2015 Research and Markets ... the "Global Cell Therapy Market Outlook 2020 " ... cell therapy in tissue and regenerative medicine is expected ... other options which could help in the growth of ... segment but they are unable to form new tissue ...
Breaking Biology Technology:5 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... Portugal , July 28, 2010 Hovione announced today,that ... 2010,amounted to USD144m , representing an increase of 15% over the ... ... its,facilities. The Company acquired an API manufacturing facility from Pfizer,in Cork, ...
... July 27 DecisionView Inc., ... trial enrollment for life sciences companies, is pleased to ... based on their successful deployment of DecisionView StudyOptimizer (see ... web-based patient enrollment optimization solution that automates the planning ...
... AVANIR Pharmaceuticals, Inc. (Nasdaq: AVNR ) ... Life Sciences Best Ideas Management Access Conference on Tuesday, August ... p.m. Pacific time ) at the Le Parker Meridien Hotel in ... companies with the opportunity to present to institutional and private equity ...
Cached Biology Technology:Hovione's Sales Grow 15% 2Pfizer Wins CIO 100 Award for Patient Enrollment Optimization Solution From DecisionView 2AVANIR to Present at the Wedbush Life Sciences Conference 2
... vapor-tight adhesive chambers for sealing hybridization reactions on ... a sample on a glass slide. Reaction solution ... the ports are then sealed with plastic sealing ... allow exchange of reaction fluid. These chambers enclose ...
... in vascular proliferation, adhesion, and wound repair ... cell adhesion receptors consists of at least ... and b subunit that associate in a ... of the integrin family are based upon ...
... Ease of Use : GeneTraffic ... software tool for biological research. GeneTraffic provides ... to validate your data prior to analysis. ... Quickly define your projects using the MIAME ...
... --- a cocktail of 3 siRNAs specifically ... our most popular product. The siTrio reagent ... of your target gene when used under ... and confirmation of optimal transfection with one ...
Biology Products: