Navigation Links
'Humanized' mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
Date:9/10/2012

PORTLAND, Ore. A novel human liver-chimeric mouse model developed at Oregon Health & Science University and Yecuris Corporation has made possible a research breakthrough at Seattle Biomedical Research Institute that will greatly accelerate studies of the most lethal forms of human malaria.

The study findings are published online in the Journal of Clinical Investigation. Study photos were selected to appear in "Scientific Show Stoppers" on the JCI blog.

Plasmodium falciparum, one of two human-specific malaria parasites, is a global health crisis, causing more than 216 million new infections annually and resulting in an estimated 655,000 deaths, according to the World Health Organization.

Sporozoites, the infectious form of the parasite, are spread to people through the bites of infected mosquitos and multiply in the human liver during the initial stages of infection. There, they undergo liver stage development, culminating in the formation and release of tens of thousands of merozoites, the parasitic phase of development that infects red blood cells.

Until now, there have been few data on human malaria liver stage biology due to the lack of a viable small animal model and because liver stage P. falciparum does not grow well in a dish. Consequently, most research and therapeutics to date have targeted the human blood stage of P. falciparum's development because it replicates well in culture.

The liver-to-blood stage of P. falciparum is the focus of this research because the parasite is virtually harmless, causing no disease symptoms, prior to its transition to the blood stage.

In this study, researchers at Seattle Biomedical Research Institute, Yecuris Corporation, Oregon Health & Science University and The Rockefeller University have demonstrated that a complete liver-to-blood stage infection of P. falciparum is possible using a unique immunocompromised mouse model
'/>"/>

Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Mini-CT scanner developed as a teaching tool
2. Blossom end rot plummets in Purdue-developed transgenic tomato
3. The first chemical circuit developed
4. Grassroots approach to conservation developed
5. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
6. Electronic nose prototype developed
7. New long-term antimicrobial catheter developed
8. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
9. New genomic sequencing method enables smarter anaysis of individual cells
10. The end of an era? Branding horses does not enable them to be identified
11. Notre Dame researchers using novel method to combat malaria drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Humanized' mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
(Date:9/18/2014)... USA Miranda, a small, icy moon of Uranus, ... bodies in the solar system. Despite its relatively small ... intense resurfacing that resulted in the formation of at ... regions called coronae. , These coronae are visible ... least 200 km across. Arden corona, the largest, has ...
(Date:9/18/2014)... Space Station ever starts a "frequent flyers" program, fruit ... the orbiting laboratory has hosted increasing numbers of fruit ... the space station in April, and another is scheduled ... is planned to launch in December. , Fruit flies ... world-- and in space. Model organisms can reveal the ...
(Date:9/18/2014)... strands of nucleic acid that contain instructions for the ... our DNA is copied into RNA molecules, which then ... our cells. , Several years ago, scientists discovered ... known RNAs, this molecule is circular, and was labeled ... been known about how they are produced. Moreover, little ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2
... Management District (SJRWMD) has contracted with Florida Tech scientists ... regarding the fish larvae and eggs (ichthyoplankton) that inhabit ... a comprehensive SJRWMD effort to address public concern regarding ... St. Johns River. One measure of the ...
... developed the first small molecule that can reversibly activate ... the way for drugs that can treat low blood ... sodium channel (ENaC) controls sodium flow across many tissues ... is vital to maintaining proper salt balance and blood ...
... the fundamental laws of the universe, science is still ... about the meaning of life, the existence of God ... Is that because science is not sufficiently advanced to ... approach to science is incapable of answering humanitys deepest ...
Cached Biology News:Grant to fund answers about St. Johns River 2Finding God with biocomplexity 2Finding God with biocomplexity 3
(Date:9/19/2014)... 2014 Barnhardt Manufacturing Company ... its Organic Cotton . The USDA Certified Biobased ... biobased ingredients meets or exceeds levels set by USDA. ... whole or in significant part of agricultural, forestry, or ... Organic cotton to be immediately identified as a USDA ...
(Date:9/19/2014)... -- Dublin ... the addition of the  "Micro Market Monitor : ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ,The ... segments in the chromatography market. The market was ... to reach $2.0 billion by 2019, at a ...
(Date:9/19/2014)... , September 19, 2014 The new ... Spain , available today on PharmaBoardroom.com for ... Eurozone crisis that rocked the Spanish economy in 2009, and ... pharma community has remained pragmatic in times of trouble. ... still the fifth biggest European market, and the general conditions ...
(Date:9/18/2014)... 2014 HealthTronics, Inc ., ... radiology products and services, announced that a poster ... cryoablation) versus external beam radiotherapy (EBRT) is being ... Urological Association (MAAUA) Annual Meeting in Baltimore, Maryland ... of Cryosurgery and External Beam Radiation as Treatments ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2
... /Xinhua-PRNewswire-FirstCall/ -- China Medical,Technologies, Inc. (the "Company") ... device company that develops, manufactures and markets ... it will report selected,unaudited financial numbers including ... for the second fiscal quarter ended September ...
... Inc. ("Carna"),announced on October 27, 2008, the signing ... ("SUBC"). Under the terms of this,Agreement, SUBC will ... China., With China,s emergence as a strong ... companies have now established,research and production facilities in ...
... value and cost-effectiveness of spinal cord stimulation, ... BSX ) today welcomed an announcement by ... (NICE) recommending,the use of spinal cord stimulation (SCS) ... final guidance, NICE confirmed that,SCS is both safe ...
Cached Biology Technology:China Medical Technologies Announces Reporting Dates for the September Quarter Results and Addresses Investor Inquiries 2China Medical Technologies Announces Reporting Dates for the September Quarter Results and Addresses Investor Inquiries 3Carna Biosciences Signs Distribution Agreement with Shanghai Universal Biotech Company 2UK's NICE Recommends Spinal Cord Stimulation for Patients with Chronic Neuropathic Pain 2UK's NICE Recommends Spinal Cord Stimulation for Patients with Chronic Neuropathic Pain 3UK's NICE Recommends Spinal Cord Stimulation for Patients with Chronic Neuropathic Pain 4UK's NICE Recommends Spinal Cord Stimulation for Patients with Chronic Neuropathic Pain 5
... Solid phase reagent for ... Easy & unique water ... with detergents and chaotropes; ... recover non-envelop viruses while ...
Handles samples from from 75l to 150l...
PKA Sampler Kit 10 mu g each...
Chaperone Sampler Kit 10 mu g each...
Biology Products: