Navigation Links
'Humanized' mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
Date:9/10/2012

PORTLAND, Ore. A novel human liver-chimeric mouse model developed at Oregon Health & Science University and Yecuris Corporation has made possible a research breakthrough at Seattle Biomedical Research Institute that will greatly accelerate studies of the most lethal forms of human malaria.

The study findings are published online in the Journal of Clinical Investigation. Study photos were selected to appear in "Scientific Show Stoppers" on the JCI blog.

Plasmodium falciparum, one of two human-specific malaria parasites, is a global health crisis, causing more than 216 million new infections annually and resulting in an estimated 655,000 deaths, according to the World Health Organization.

Sporozoites, the infectious form of the parasite, are spread to people through the bites of infected mosquitos and multiply in the human liver during the initial stages of infection. There, they undergo liver stage development, culminating in the formation and release of tens of thousands of merozoites, the parasitic phase of development that infects red blood cells.

Until now, there have been few data on human malaria liver stage biology due to the lack of a viable small animal model and because liver stage P. falciparum does not grow well in a dish. Consequently, most research and therapeutics to date have targeted the human blood stage of P. falciparum's development because it replicates well in culture.

The liver-to-blood stage of P. falciparum is the focus of this research because the parasite is virtually harmless, causing no disease symptoms, prior to its transition to the blood stage.

In this study, researchers at Seattle Biomedical Research Institute, Yecuris Corporation, Oregon Health & Science University and The Rockefeller University have demonstrated that a complete liver-to-blood stage infection of P. falciparum is possible using a unique immunocompromised mouse model
'/>"/>

Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Mini-CT scanner developed as a teaching tool
2. Blossom end rot plummets in Purdue-developed transgenic tomato
3. The first chemical circuit developed
4. Grassroots approach to conservation developed
5. Composite nanofibers developed by Penn scientists next chapter in orthopaedic biomaterials
6. Electronic nose prototype developed
7. New long-term antimicrobial catheter developed
8. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
9. New genomic sequencing method enables smarter anaysis of individual cells
10. The end of an era? Branding horses does not enable them to be identified
11. Notre Dame researchers using novel method to combat malaria drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Humanized' mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
(Date:10/29/2014)... as ,facultative, form part—together with other cells—of tissues and ... from the others. However, they have a very special ... cells again. This phenomenon is something that happens in ... tissue growth, thus allowing the regeneration of the organ ... the underlying mechanism that allows these cells to retain ...
(Date:10/29/2014)... organisms in the living world compete with members ... in how much they invest into their competitive ... to get access to high-quality resources, while others ... of the lower-quality resources that are left over ... animal and human societies seems to fluctuate considerably ...
(Date:10/29/2014)... cohort of kidney cancer patients in Europe sheds light ... reveals an apparent link between exposure to aristolochic acid ... The research, by an international team led by scientists ... in Montreal, underscores the importance of investigating possible sources ... plants of the Aristolochia genus, also has been suspected ...
Breaking Biology News(10 mins):A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Evolution of competitiveness 2Evolution of competitiveness 3Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3
... "At the dawn of the 21st century, we are faced with ... world has grown at a rapid pace, turning the demand for ... Gebisa Ejeta (winner of the world food prize 2009) who is ... held in Lancaster, UK, 13 15th September 2010. ...
... Tenn., Sept. 9, 2010 -- Exemplary efforts to "go ... a 2010 Federal Energy & Water Management Award and ... of the lab,s Sustainable Campus Initiative. The ... Management Program recognized ORNL for its outstanding achievements in ...
... SEPTEMBER 9, 2010 The American Society of Agronomy ... Awards Ceremony on Nov. 2 during the scientific society,s ... The annual awards are presented for outstanding contributions to ... , Alan Blaylock, Agrium Advanced Technologies ...
Cached Biology News:ORNL wins 2 awards for sustainability program 2American Society of Agronomy announces award recipients 2American Society of Agronomy announces award recipients 3American Society of Agronomy announces award recipients 4
(Date:10/27/2014)... 2014 Kalorama Information says that PCR is ... the United States and is ... researcher said the FDA,s Emergency Use Authorization (EUA) to authorize ... the detection of the Ebola virus was an indication ... assess the IVD industry and its biennial survey on ...
(Date:10/27/2014)... Orlando, Florida (PRWEB) October 27, 2014 ... aims at reducing and eliminating several types of ... have not been achieved in over 30 years ... of Noah's Light Foundation, proves that one mom's ... was diagnosed just before Halloween trick-or-treating, and it’s ...
(Date:10/27/2014)... 2014 Janssen Biotech, Inc. and the ... today the launch of Get Your ... campaign designed to provide resources for people living ... role of nutrition and appropriate therapy in managing ... associated with this release, please click: http://www.multivu.com/players/English/7261131-janssen-ccfa-get-your-full-course-for-ibd-wellness-with-sunny-anderson/ ...
(Date:10/26/2014)... 2014 The report "Protective Coatings Market ... Global Trends & Forecast to 2019", defines and segments ... of volume consumed and value generated. The protective coatings ... 2014 to 6,701.3 KT by 2019, at a CAGR ... market data tables and 22 figures spread through 219 ...
Breaking Biology Technology:Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 2Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 3Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 4
... Zone Sonography Technology Allows Premium Compact Ultrasound Imaging at ... Area,s Leading Healthcare ... a,leading regional healthcare provider and member of Sutter Health, today,announced ... a developer of premium ultrasound technology, in the Center,s,radiology department. ...
... Sept. 19 CellCyte Genetics,Corporation (the "Company") (OTC ... in order to develop, manufacture and market its ... CellCyte Genetics is developing stem cell enabling ... significantly increased,retention of adult stem cells to diseased ...
... of DelSite cGMP Polymer, IRVING, Texas, ... CARN) today announced its wholly-owned,subsidiary, DelSite Biotechnologies, ... agreement with a biotechnology company for,transdermal delivery ... polysaccharide which is produced under cGMP,with high ...
Cached Biology Technology:Memorial Medical First in Stanislaus County to Provide Convertible Ultrasound From ZONARE 2Memorial Medical First in Stanislaus County to Provide Convertible Ultrasound From ZONARE 3CellCyte Genetics Corp. Forms Device Division to Develop and Manufacture Stem Cell Cultivation and Replication Products 2CellCyte Genetics Corp. Forms Device Division to Develop and Manufacture Stem Cell Cultivation and Replication Products 3CellCyte Genetics Corp. Forms Device Division to Develop and Manufacture Stem Cell Cultivation and Replication Products 4Carrington Subsidiary DelSite Biotechnologies Enters into Technology Evaluation Rights License Agreement for Transdermal Delivery of Vaccines 2Carrington Subsidiary DelSite Biotechnologies Enters into Technology Evaluation Rights License Agreement for Transdermal Delivery of Vaccines 3
... Ascent FL is equipped ... luminometric measurement technologies that ... of advanced features of ... Ascent. Fluoroskan Ascent FL ...
... Thermo's orbital shaker stands both ... more ergonomic height, and help ... from welded tubular steel, these ... support the weight and minimize ...
... Polyribonucleotides (RNA polymers) are ... action of the enzyme, ... Midland, and the appropriate, ... With the exception of ...
...
Biology Products: