Navigation Links
Human vascular system in mice
Date:4/14/2008

The formation of new blood vessels, or angiogenesis, is an Achilles heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival. Therefore, for some years now substances called angiogenesis inhibitors have been used in cancer treatment to suppress this process. In order to advance this new research field, a team of researchers headed by Professor Hellmut Augustin has developed a method to create a complex human vascular system in mice, which stays functional even after several months.

The method is based on the observation that isolated cells of the vessel walls, called endothelial cells, congregate spontaneously in cell cultures to form aggregates known as spheroids. Individual endothelial cells floating in suspension are doomed to die the association in spheroids stabilizes them, says Hellmut Augustin. The scientists Abdullah Alajati and Anna Laib have been able to inject such spheroids, embedded in a gel matrix, under the skin of mice and to stimulate the formation of a network of human blood vessels by means of growth factors. The mice were genetically modified in such a way that their immune system was unable to reject the foreign cells. The newly formed blood vessels are made exclusively of human endothelial cells, explains Anna Laib, a young researcher at the DKFZ. At the matrix borders the human endothelial cells establish contact with those of the mouse. In this way, the transplanted human vasculature gets connected to the blood circulation of the mouse.

The method provides experimental freedom and may deliver answers to various questions of vascular biology research. Scientists can genetically manipulate the endothelial cells before transplantation in order to investigate the formation of vascular networks. In addition, it is possible to test the effect of pharmacological substances; the Freiburg-based company ProQinase GmbH, which is involved in the study, is already conducting such experime
'/>"/>

Contact: Dr. Stefanie Seltmann
s.seltmann@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Antioxidant overload may underlie a heritable human disease
3. Facial attraction -- choice of sexual partner shaped the human face
4. Humans fostering forest-destroying disease
5. SRMs track fire retardants in humans and environment
6. St. Jude influenza survey uncovers key differences between bird flu and human flu
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Gene regulation in humans is closer than expected to simple organisms
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. Researchers developing device to predict proper light exposure for human health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Human vascular system in mice
(Date:1/22/2015)... Infinisource has launched its new NXG series of time ... sets a higher standard for collecting attendance and labor data ... plug-and-play installation, touch screen interface and seamless connection to cloud-based ... collection solution for the small to mid-size employer. ...
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... the addition of the "The Global Watermarking ... http://photos.prnewswire.com/prnh/20130307/600769 ... global digital media watermarking and fingerprinting markets. Watermarking ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ... Monitor: North America Perimeter Security Systems Market" report to ... The North American perimeter security market is estimated to ... Although the U.S. market holds a larger share in this ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... October 2011 A young scientist who led research into the ... surface disease has been named the winner of the Young Investigator ... will be presented with her award at The Stem Cell Symposium, ... 2011. The $10,000 prize is awarded annually to a young scientist ...
... primary producers of ammonia in Houston,s atmosphere, and cars and ... to a new study by researchers at Rice University and ... quality draws minimal oversight from the Environmental Protection Agency (EPA), ... means to life in and around the metropolis. ...
... microscopical water channels are also present in the cells ... transported through the protective surface of the cell. Scientists at ... of the body,s water channels can be modified such that ... the treatment of several diseases. "It,s important to understand ...
Cached Biology News:Regenerating eyes using cells from hair: Stem Cells awards research into stem cell deficiency 2Ammonia gets overdue overview 2Ammonia gets overdue overview 3Water channels in the body help cells remain in balance 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited ... seminar on probiotics in San Diego, CA. , The ... for health care professionals. This year’s pre-conference seminar was held ... health. Dr. Leyer spoke about the emerging topics and science ...
(Date:1/22/2015)... Nueva Jersey , 22 de enero de 2015  El ... abre hoy su llamada a nominaciones para 2015. Este ... ha hecho, o tiene el potencial para hacer, contribuciones ... nominaciones se aceptarán hasta el 15 de marzo de ...
(Date:1/22/2015)... N.J. , Jan. 22, 2015  Derma Sciences, ... regeneration company focused on advanced wound care, announces ... placental tissues, have been added to the Premier, ... increases the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® ...
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... Sept. 15 CMS, Inc., an Elekta Company ... management,solutions, today announced the commercial launch of its ... of the Focal product line that also includes ... that support the,visualization and utilization of 4D image ...
... BUFFALO, N.Y., Sept. 15 Kinex Pharmaceuticals announced,that ... Company,s Board of,Directors., Dr. Hsia is a ... a publicly traded company listed in New York ... President, Scientific,Affairs of Watson Pharmaceuticals before his retirement. ...
... -- Sinovac Biotech Ltd. (Amex:,SVA), a leading provider ... clinical trials in Ukraine for its inactivated hepatitis ... being conducted by,Biolik Biopharmaceutical Company, a vaccine manufacturer ... the Country. Biolik will,also market and distribute Healive ...
Cached Biology Technology:CMS, Inc., an Elekta Company, Announces Commercial Availability of Focal4D(TM) 2Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 2Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 3
Evolutionarily conserved signaling intermediate in Toll pathway...
Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta). [Source:Uniprot/SWISSPROT;Acc:P48739] Antigen: Recombinant Protein Epitope Signature Tag...
Mouse monoclonal [88B] to nicotinic Acetylcholine Receptor ( Abpromise for all tested applications)....
PPIF Antibody...
Biology Products: