Navigation Links
Human vascular system in mice

The formation of new blood vessels, or angiogenesis, is an Achilles heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival. Therefore, for some years now substances called angiogenesis inhibitors have been used in cancer treatment to suppress this process. In order to advance this new research field, a team of researchers headed by Professor Hellmut Augustin has developed a method to create a complex human vascular system in mice, which stays functional even after several months.

The method is based on the observation that isolated cells of the vessel walls, called endothelial cells, congregate spontaneously in cell cultures to form aggregates known as spheroids. Individual endothelial cells floating in suspension are doomed to die the association in spheroids stabilizes them, says Hellmut Augustin. The scientists Abdullah Alajati and Anna Laib have been able to inject such spheroids, embedded in a gel matrix, under the skin of mice and to stimulate the formation of a network of human blood vessels by means of growth factors. The mice were genetically modified in such a way that their immune system was unable to reject the foreign cells. The newly formed blood vessels are made exclusively of human endothelial cells, explains Anna Laib, a young researcher at the DKFZ. At the matrix borders the human endothelial cells establish contact with those of the mouse. In this way, the transplanted human vasculature gets connected to the blood circulation of the mouse.

The method provides experimental freedom and may deliver answers to various questions of vascular biology research. Scientists can genetically manipulate the endothelial cells before transplantation in order to investigate the formation of vascular networks. In addition, it is possible to test the effect of pharmacological substances; the Freiburg-based company ProQinase GmbH, which is involved in the study, is already conducting such experiments. The method is even interesting for the production of artificial tissues, Hellmut Augustin says. So far, one difficulty with the use of artificial replacement tissues has been to create a functioning vascular system that sufficiently supplies the tissue constructs.


Contact: Dr. Stefanie Seltmann
Helmholtz Association of German Research Centres

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Antioxidant overload may underlie a heritable human disease
3. Facial attraction -- choice of sexual partner shaped the human face
4. Humans fostering forest-destroying disease
5. SRMs track fire retardants in humans and environment
6. St. Jude influenza survey uncovers key differences between bird flu and human flu
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
9. Gene regulation in humans is closer than expected to simple organisms
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. Researchers developing device to predict proper light exposure for human health
Post Your Comments:
Related Image:
Human vascular system in mice
(Date:11/4/2015)... , November 4, 2015 ... market report published by Transparency Market Research "Home Security Solutions ... and Forecast 2015 - 2022", the global home security solutions ... bn by 2022. The market is estimated to expand ... from 2015 to 2022. Rising security needs among customers ...
(Date:10/29/2015)... Oct. 29, 2015  Rubicon Genomics, Inc., today ... distribution of its DNA library preparation products, including ... new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has been ... of NGS libraries for liquid biopsies--the analysis of ... prognostic applications in cancer and other conditions. Eurofins ...
(Date:10/27/2015)... -- Munich, Germany , October ... automatically maps data from mobile eye tracking videos created ... that they can be quantitatively analyzed with SMI,s analysis ... , October 28-29, 2015. SMI,s Automated Semantic Gaze ... tracking videos created with SMI,s Eye Tracking Glasses ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> Accutest Research Laboratories, ... Contract Research Organization (CRO), has formed ... Cancer Center - Temple Health for ... ,     (Photo: ) , ...
(Date:11/25/2015)... , Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: ... adopted a stockholder rights plan (Rights Plan) in an ... loss carryforwards (NOLs) under Section 382 of the Internal ... --> PharmAthene,s use of its NOLs could be ... as defined in Section 382 of the Code. In ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... the Organization of Black Aerospace Professionals (OPBAP) has been formalized with the signing ... AMA team leaders met with OPBAP leaders Capt. Karl Minter and Capt. Albert ...
Breaking Biology Technology: