Navigation Links
Human umbilical cord blood cells aid diabetic wound healing
Date:2/22/2011

Tampa, Fla. (Feb. 22, 2011) Transplanting human umbilical cord blood-derived endothelial progenitor cells (EPCs) has been found to "significantly accelerate" wound closure in diabetic mouse models, said a team of Korean researchers publishing in the current issue of Cell Transplantation (19:12), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

According to the study's corresponding author, Dr. Wonhee Suh of the CHA University Stem Cell Institute, diabetes is often associated with impaired wound healing. While the therapeutic potential of transplanted EPCs has been demonstrated in animal models and in humans who have suffered stroke, myocardial infarction and peripheral artery disease, their effect in healing stubborn wounds has not been studied to the same degree.

"EPCs are involved in revascularization of injured tissue and tissue repair," said Dr. Suh. "Wounds associated with diabetes that resist healing are also associated with decreased peripheral blood flow and often resist current therapies. Normal wounds, without underlying pathological defects heal readily, but the healing deficiency of diabetic wounds can be attributed to a number of factors, including decreased production of growth factors and reduced revascularization.

The researchers, who transplanted EPCs into an experimental group of mice modeled with diabetes-associated wounds, but did not transplant EPCs into a control group, found that the EPCs "prompted wound healing and increased neovascularization" in the experimental group.

"The transplantation of EPCs derived from human umbilical blood cells accelerated wound closure in diabetic mice from the earliest point," said Dr. Suh. "Enhanced re-epithelialization made a great contribution in accelerating wound closure rate."

The researchers found that growth factors and cytokines (small proteins secreted by specific cells of the immune system) were "massively produced" at the wounded skin sites and contributed to the healing process.

"It remains unclear, however, which mechanism plays the dominant role in EPC-mediated tissue regeneration," commented Dr. Suh. "Further study is required since numerous studies have shown that the actual magnitude of EPC incorporation into the vasculature varies substantially from study to study."

"This experimental study opens the possibility of the future clinical use of endothelial progenitor cells derived from human cord blood in the treatment of diabetic wounds in humans" said Prof. Voltarelli, Professor of Clinical Medicine & Clinical Immunology at the University of Sao Pulo, Brazil and section editor for Cell Transplantation . "Interestingly, it also shows that the culture medium used to grow the cells (conditioned media) has the same healing effect as the cells, so that it could be used as a cell-free form of treatment."


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
2. Scientists identify novel inhibitor of human microRNA
3. During exercise, the human brain shifts into high gear on alternative energy
4. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
5. Research shows Brazilian acai berry antioxidants absorbed by human body
6. Study: Bird diversity lessens human exposure to West Nile Virus
7. Human Microbiome Project awards funds for technology development, data analysis and ethical research
8. TheVisualMD.com launches new animated 3-D views of human body in action
9. Gene with probable role in human susceptibility to pulmonary tuberculosis identified
10. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
11. Genetic based human diseases are an ancient evolutionary legacy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
(Date:5/12/2016)... 12, 2016 WearablesResearch.com , a brand ... overview results from the Q1 wave of its quarterly ... was consumers, receptivity to a program where they would ... health insurance company. "We were surprised to ... Michael LaColla , CEO of Troubadour Research, "primarily ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking ... Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity as ...
Breaking Biology Technology: