Navigation Links
Human taste cells regenerate in a dish
Date:4/6/2011

PHILADELPHIA (April 6, 2011) Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease.

This advance ultimately will assist efforts to prevent and treat taste loss or impairment due to infection, radiation, chemotherapy and chemical exposures.

"People who undergo chemotherapy or radiation therapy for oral cancer often lose their sense of taste, leading to decreased interest in food, weight loss, and malnutrition," said lead author M. Hakan Ozdener, M.D., Ph.D., M.P.H., a cellular biologist at Monell. "The success of this technique should provide hope for these people, as it finally provides us with a way to test drugs to promote recovery."

Taste cells are found in papillae, the little bumps on our tongues. These cells contain the receptors that interact with chemicals in foods to allow us to sense sweet, salty, sour, bitter, and umami. They also are among the few cells in the body with the special capacity to regenerate, with new taste cells maturing from progenitor 'stem' cells every 10-14 days.

For many years it was believed that taste cells needed to be attached to nerves in order to both function properly and regenerate. For this reason, scientists thought that it was not possible to isolate and grow these cells in culture, which limited the scope of studies to understand how human taste cells function.

"It had become engrained in the collective consciousness that it wouldn't work," said Monell cellular biologist Nancy E. Rawson, Ph.D

To dispel the long-held belief, the Monell scientists first demonstrated in 2006 that taste cells from rats could successfully be maintained in culture. In the current study, published online in the journal Chemical Senses, they then applied that methodology to a more clinically relevant population humans.

Taking tiny samples of tongue tissue from human volunteers, the researchers first adapted existing techniques to demonstrate that the human taste cells indeed can regenerate in culture.

They went on to show that the new taste cells were functional, maintaining key molecular and physiological properties characteristic of the parent cells. For example, the new cells also were activated by sweet and bitter taste molecules.

"By producing new taste cells outside the body, our results demonstrate that direct stimulation from nerves is not necessary to generate functional taste cells from precursors," said Ozdener.

The establishment of a feasible long-term taste cell culture model opens a range of opportunities to increase understanding of the sense of taste.

"Results from these cells are more likely to translate to the clinic than those obtained from other species or from systems not derived from taste tissue," said Rawson.

The cells also can be used to screen and identify molecules that activate the taste receptors; one such example might be a salt replacer or enhancer.

"The model will help scientists identify new approaches to design and establish cell culture models for other human cells that previously had resisted viable culture conditions," said Ozdener


'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Related biology news :

1. Worlds reef fishes tussling with human overpopulation
2. 18th International Academy of Astronautics Humans in Space Symposium
3. In vitro infection and replication of hepatitis E virus in human hepatocytes
4. Human impacts on the marine ecosystems of Antarctica
5. Human virus linked to deaths of endangered mountain gorillas
6. Study indicates vitamin A plays key role in the human body
7. Method reveals new view of human nerve cells, opening door to potential drug targets
8. Humans give prey the edge in food web
9. Mapping human vulnerability to climate change
10. U. Iowa team investigates function of junk DNA in human genes
11. Missing sugar molecule raises diabetes risk in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... Mosio, a leader in clinical research ... Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the ... tools, and strategies for clinical researchers. , “The landscape of how patients receive ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
Breaking Biology Technology: