"We are reminded today of the strong link between scientific advancement and human rights protections," said Dr. Brigitte Schmied, AIDS 2010 Local Co-Chair and President of the Austrian AIDS Society. "Science is now poised to give us another important new tool to help women protect themselves from HIV and save lives."
New Concepts in HIV/AIDS Pathogenesis: Implications for Interventions
In his plenary remarks, Dr. Anthony Fauci (United States) of the National Institute of Allergy and Infectious Diseases focused on the early and complex pathogenic events that occur within the first hours to days of sexual exposure to HIV. These early events, which include the spread of virus to lymphoid tissue and the establishment of viral reservoirs, determine the subsequent course of HIV infection and represent a period of vulnerability for the virus that provides a window of opportunity for intervention. Fauci discussed how growing understanding of these events is informing the development of HIV vaccines, other new prevention interventions, early treatment of HIV infection and potentially a cure in certain individuals.
Among other topics, Fauci discussed recent data from his laboratory on the role of a receptor for the HIV envelope on the surface of CD4+ T cells called α4β7 that, in certain forms, defines a subset of CD4+ T cells that are highly susceptible to productive HIV infection. α4β7 is a cellular protein that guides immune system cells to the gut. In HIV infection, the gut is rapidly depleted of CD4+ T cells, the main target of HIV, triggering the process that ultimately leads to AIDS. Fauci suggests that an HIV envelope conformation that allows initial binding to α4β7 on mucosal CD4+ T cells sho
|Contact: Regina Aragon|
International AIDS Society