Navigation Links
Human protein atlas will help pinpoint disease
Date:10/17/2008

Researchers in Sweden are compiling a remarkable 'atlas' that pinpoints the location of thousands of individual proteins in the body's tissues and cells which will give scientists important insights into the function of different proteins and how changes in the distribution of proteins could be reflected in diseases such as cancer. Professor Mathias Uhln of the Royal Institute of Technology in Stockholm, who is leading the project, said, "We are trying to map the building blocks of life."

The project is hugely ambitious, relying on the selective identification and mapping of thousands of proteins, many of whose function is not yet known, and has required the development of a massive infrastructure to enable the proteins to be identified in a realistic period of time.

Uhln was describing the human protein atlas at the European Science Foundation's 3rd Functional Genomics Conference in Innsbruck, Austria, on 1-4 October. Functional genomics describes the way in which genes and their products, proteins, interact together in complex networks in living cells. If these interactions are abnormal, diseases can result. The Innsbruck meeting brought together more than 450 scientists from across Europe to discuss recent advances in the role of functional genomics in disease.

The protein atlas team first uses the human genome the sequence of all the 20000 or so genes in human cells to encode individual proteins. They then develop 'antibodies' protein molecules that recognise specific targets against each of these proteins. The antibody that recognises a given protein is then labelled with a marker to render it visible under a microscope and is exposed to samples of different tissues and cells. The antibody binds to the proteins and in this way the location of the protein can be detected.

"To do this systematically requires a lot of automation and robotics," Uhln said. "We have six software engineers writing codes just to keep track on the samples. The project is generating 400 gigabytes of data every day." There is a 100-strong team working on the project, with a site due to be set up soon in India, and with antibody-producing sites in Korea and China.

"To get an idea of how far we have come, in our first year we produced on antibody," said Uhln. "This year we are hoping we can make 3000." The programme was launched in 2003, and with sufficient funding the first full version of the atlas could be available by 2014, Uhln believes.

The team has so far mapped the location of around 5000 proteins in human cells and tissues. The researchers are also investigating whether certain common cancers colon, prostate, lung and breast have different protein profiles to normal tissue. In this way new 'biomarkers' could be identified molecules which indicate that a tissue or cell is in a diseased state, which could alert doctors to the early stages of a disease.


'/>"/>

Contact: Mathias Uhln
Uhlen@biotech.kth.se
46-855-378-325
European Science Foundation
Source:Eurekalert

Related biology news :

1. Genetic based human diseases are an ancient evolutionary legacy
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Gene with probable role in human susceptibility to pulmonary tuberculosis identified
4. TheVisualMD.com launches new animated 3-D views of human body in action
5. Human Microbiome Project awards funds for technology development, data analysis and ethical research
6. Study: Bird diversity lessens human exposure to West Nile Virus
7. Research shows Brazilian acai berry antioxidants absorbed by human body
8. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
9. During exercise, the human brain shifts into high gear on alternative energy
10. Scientists identify novel inhibitor of human microRNA
11. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... Nov. 14, 2016  Based on its ... Frost & Sullivan recognizes FST Biometrics with ... for Visionary Innovation Leadership. FST Biometrics emerged ... identification market by pioneering In Motion Identification ... instant, seamless, and non-invasive verification. This patented ...
(Date:6/22/2016)... June 22, 2016 On Monday, the Department ... industry to share solutions for the Biometric Exit Program. ... and Border Protection (CBP), explains that CBP intends to ... the United States , in order ... defeat imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... ... findings demonstrating the value of DNA microarray comparative genomic hybridization (array CGH) ... Antonio Breast Cancer Symposium. Using molecular test results from tumors with previously ...
(Date:12/2/2016)... ... 01, 2016 , ... DrugDev believes the only way to achieve ... experience. All three tenets were on display at the 2nd Annual DrugDev User Summit ... sponsor, CRO and site organizations to discuss innovation and the future of clinical research. ...
(Date:12/2/2016)... , Dec. 1, 2016   SurePure, Inc. ... announced today that the Company has concluded an agreement ... right for a 90-day period to acquire units of ... of approximately USD 3.7 million.  Concurrently ... with Tamarack under which Tamarack will seek regulatory approvals ...
(Date:11/30/2016)...  GenomOncology today announced the appointment of Joshua F. ... Dr. Coleman will oversee clinical content development and ... The GenomOncology software suite empowers molecular pathologists with a seamless ... decision support, from quality control through reporting. ... , , ...
Breaking Biology Technology: