Navigation Links
Human protein atlas will help pinpoint disease
Date:10/17/2008

Researchers in Sweden are compiling a remarkable 'atlas' that pinpoints the location of thousands of individual proteins in the body's tissues and cells which will give scientists important insights into the function of different proteins and how changes in the distribution of proteins could be reflected in diseases such as cancer. Professor Mathias Uhln of the Royal Institute of Technology in Stockholm, who is leading the project, said, "We are trying to map the building blocks of life."

The project is hugely ambitious, relying on the selective identification and mapping of thousands of proteins, many of whose function is not yet known, and has required the development of a massive infrastructure to enable the proteins to be identified in a realistic period of time.

Uhln was describing the human protein atlas at the European Science Foundation's 3rd Functional Genomics Conference in Innsbruck, Austria, on 1-4 October. Functional genomics describes the way in which genes and their products, proteins, interact together in complex networks in living cells. If these interactions are abnormal, diseases can result. The Innsbruck meeting brought together more than 450 scientists from across Europe to discuss recent advances in the role of functional genomics in disease.

The protein atlas team first uses the human genome the sequence of all the 20000 or so genes in human cells to encode individual proteins. They then develop 'antibodies' protein molecules that recognise specific targets against each of these proteins. The antibody that recognises a given protein is then labelled with a marker to render it visible under a microscope and is exposed to samples of different tissues and cells. The antibody binds to the proteins and in this way the location of the protein can be detected.

"To do this systematically requires a lot of automation and robotics," Uhln said. "We have six software engineers writing codes just to keep track on the samples. The project is generating 400 gigabytes of data every day." There is a 100-strong team working on the project, with a site due to be set up soon in India, and with antibody-producing sites in Korea and China.

"To get an idea of how far we have come, in our first year we produced on antibody," said Uhln. "This year we are hoping we can make 3000." The programme was launched in 2003, and with sufficient funding the first full version of the atlas could be available by 2014, Uhln believes.

The team has so far mapped the location of around 5000 proteins in human cells and tissues. The researchers are also investigating whether certain common cancers colon, prostate, lung and breast have different protein profiles to normal tissue. In this way new 'biomarkers' could be identified molecules which indicate that a tissue or cell is in a diseased state, which could alert doctors to the early stages of a disease.


'/>"/>

Contact: Mathias Uhln
Uhlen@biotech.kth.se
46-855-378-325
European Science Foundation
Source:Eurekalert

Related biology news :

1. Genetic based human diseases are an ancient evolutionary legacy
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Gene with probable role in human susceptibility to pulmonary tuberculosis identified
4. TheVisualMD.com launches new animated 3-D views of human body in action
5. Human Microbiome Project awards funds for technology development, data analysis and ethical research
6. Study: Bird diversity lessens human exposure to West Nile Virus
7. Research shows Brazilian acai berry antioxidants absorbed by human body
8. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
9. During exercise, the human brain shifts into high gear on alternative energy
10. Scientists identify novel inhibitor of human microRNA
11. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... 2016 , ... Proove Biosciences, Inc ., the commercial ... of the Proove Health Foundation . The Foundation is a non-profit organization ... of personalized medicine for tackling the nation’s most-pressing healthcare epidemics. As part of ...
(Date:4/29/2016)... ... April 29, 2016 , ... During a two day ... a viable company, CereScan’s CEO, John Kelley, joined other Denver business leaders in ... mentor in the Denver area business community, shared his top fundamental learnings in ...
(Date:4/29/2016)... TURIN, Italy , April 29, 2016 ... version 5.11, the latest update to its industry-leading treatment ... has shown that Monaco version ... Users can now attain calculation speeds up to four ... Monaco . With the industry,s gold standard ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... ongoing support for Connecticut's innovative, growing companies, today announced the launch of ... financial technology (fintech) companies. , “VentureClash looks to attract the best ...
Breaking Biology Technology: