Navigation Links
Human microbe study provides insight into health, disease
Date:3/18/2013

Microbes from the human mouth are telling Oak Ridge National Laboratory scientists something about periodontitis and more after they cracked the genetic code of bacteria linked to the condition.

The finding, published in Proceedings of the National Academy of Sciences, profiles the SR1 bacteria, a group of microbes present in many environments, ranging from the mouth to deep within the Earth, that have never been cultivated in the laboratory. Human oral SR1 bacteria are elevated in periodontitis, a disease marked by inflammation and infection of the ligaments and bones that support the teeth.

Scientists also found that the SR1 bacteria employ a unique genetic code in which the codon UGA a sequence of nucleotides guiding protein synthesis -- appears not to serve its normal role as a stop code. In fact, scientists found that UGA serves to introduce a glycine amino acid instead.

"This is like discovering that in a language you know well there is a dialect in which the word stop means go," said co-author Mircea Podar of the Department of Energy lab's Biosciences Division. Podar and Dieter Sll of Yale University led the team that also included scientists from DOE's Joint Genome Institute who contributed to the analysis of the single-cell sequencing data.

The researchers believe the altered genetic code limits the exchange of genes between SR1 and other bacteria because they use a different genetic alphabet.

"In the big pool of bacteria, genes can be exchanged between species and can contribute to increased antibiotic resistance or better adaptation to living in humans," Podar said. "Because SR1 has a change in its genetic alphabet, its genes will not function in other microbes."

Podar and colleagues envision this work providing a path toward a better understanding of microbiological factors of periodontitis as well as to the establishment of a framework to help scientists interpret genomic data from this bacterium and others that have the same altered genetic code.

"So far, no one has been able to isolate and cultivate this type of bacterium," said Podar, who noted that there are bugs in our mouth that we have no clue about and, until now, this was one of them. "The genetic information obtained by sequencing one single cell may offer researchers a key to 'domesticating' these organisms and studying them in the laboratory."


'/>"/>

Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
4. A birds song may teach us about human speech disorders
5. Scientists produce eye structures from human blood-derived stem cells
6. Human noise has ripple effects on plants
7. Did climate change shape human evolution?
8. Harmless human virus may be able to boost the effects of chemotherapy
9. Study resolves debate on human cell shut-down process
10. Fine-scale analysis of the human brain yields insight into its distinctive composition
11. Bartonella infection associated with rheumatoid illnesses in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... DALLAS , June 20, 2016 ... criminal justice technology solutions for public safety, investigation, ... by the prisons involved, it has secured the ... Corrections (DOC) facilities for Managed Access Systems (MAS) ... (4) additional facilities to be installed by October, ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... has joined STACS DNA as a Field Application Specialist. , “I am thrilled ... COO of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... San Francisco, CA (PRWEB) , ... June 23, ... ... capture (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase ... DIA Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting ...
Breaking Biology Technology: