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Human immune cells react sensitively to 'stress'
Date:2/2/2012

o their extreme sensitivity to ROS. In turn, fewer monocytes mean fewer macrophages and consequently lower levels of ROS all in all a sophisticated way of regulating the monocyte/macrophage/dendritic cell system. It is clear that this has potential clinical implications: In the case of chronic inflammatory diseases in particular, the body is in a state of imbalance and excessive amounts of ROS are produced, which results in damage to the genetic substance of the healthy cells and is a contributing factor to the onset of cancer. It is possible that this vicious circle could be interrupted by the selective elimination of monocytes in the inflamed tissue.


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Contact: Professor Dr. Bernd Kaina
kaina@uni-mainz.de
49-613-117-9217
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

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