Navigation Links
Human hormone blocker found to help prevent obesity and diabetes: study
Date:1/3/2008

groups of mice was also analyzed.

Key Findings

Highlights of the research findings include the following:

  • Compared with the standard rodent diet (control), the mice that were fed the high-fat diet for the previous 160 days exhibited increased body weight, energy intake, and circulating glucose concentrations. The levels remained elevated throughout the study. The cholesterol and triglycerides levels increased at day 50.

  • consumption of the high fat diet resulted in progressive weight gain and elevations of plasma glucose and gyrated hemoglobin, leading to impaired insulin sensitivity and glucose intolerance by 10 days. Fat (adipose) tissue deposits were increased as were circulating cholesterol and triglyceride concentration levels.

  • (Pro3)GIP was able to counter many of the detrimental effects of high fat diet on body weight and indices of glucose and lipid metabolism.

Conclusion

This study showed that blocking GIP activity using (Pro3)GIP in mice with established, high fat diet-induced obesity and diabetes results in significant weight loss, improvement of insulin resistance and amelioration of diabetes. These findings represent an interesting new approach to the treatment of obesity and metabolic disturbances.

According to the research teams Nigel Irwin, Ph.D., "Interestingly, possible parallels exist with the benefits of Roux-en-Y surgery (gastric bypass surgery) in treating gross obesity and associated diabetes in people. In this procedure, nutrients surgically bypass the area of the small intestine, resulting in a deficiency of circulating GIP. We are looking to better understand how and why."


'/>"/>

Contact: Donna Krupa
DKrupa@The-APS.org
301-634-7209
American Physiological Society
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. There is powerful evidence of evolution in human DNA
2. Where and why humans made skates out of animal bones
3. NIH launches Human Microbiome Project
4. Final preparations for first human-rated spacecraft to be lauched from Europes Spaceport
5. Like humans, monkey see, monkey plan, monkey do
6. Humans appear hardwired to learn by over-imitation
7. New chimeric mouse model for human liver diseases, drug testing
8. Humans not the major target of Shiga toxin
9. Young chimps top adult humans in numerical memory
10. Human embryonic stem cell -- derived bone tissue closes massive skull injury
11. Duke scientists map imprinted genes in human genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... (ESA) is very pleased to announce that it has ... from the University of Wisconsin. , The ... international, open-access, peer-reviewed journal that publishes papers on all ... -- from the molecular to the ecological -- as ... freely available to individuals and institutions, and it provides ...
(Date:4/24/2014)... study of animal intelligence to-date finds that animals with bigger ... week in the journal Proceedings of the National Academy ... history of research aimed at understanding the animal mind. Specifically, ... and use tools, read social cues, or even understand basic ... of animal intelligence have focused on only one or a ...
(Date:4/24/2014)... veterans returning home from Iraq and Afghanistan, post-traumatic stress ... medical institutions and the culture at-large. Estimates indicate that ... Iraq and Afghanistan suffer from PTSD. New research from ... shedding light on how PTSD is linked to other ... in PTSD has implications beyond the impact of the ...
Breaking Biology News(10 mins):ESA to publish the Journal of Insect Science 2Animals with bigger brains, broader diets have better self control 2Animals with bigger brains, broader diets have better self control 3New study links inflammation in those with PTSD to changes in microRNA 2New study links inflammation in those with PTSD to changes in microRNA 3
... Research Laboratory's Marine Meteorology Division in Monterey, CA, ... Research Institute and the National Geophysical Data Center, ... known as the "milky sea." The satellite ... research was published in the October 4, 2005, ...
... consider giving thanks for the bacteria-busting ability of cranberry ... beverage holds important clues for preventing cavities. , ... D.D.S., Ph.D., at the University of Rochester Medical Center ... juice a powerful weapon against bladder infections also hold ...
... silenced in lung cancer causes the cells to self-destruct. The ... disease. , The research focused on a gene known ... majority of lung cancers, and in cancers of the breast, ... by scientists at The Ohio State University Comprehensive Cancer Center ...
Cached Biology News:NRL scientists detect 'milky sea' phenomena 2NRL scientists detect 'milky sea' phenomena 3Give thanks for the cranberry, say dental researchers 2Give thanks for the cranberry, say dental researchers 3Restoring silenced suppressor gene kills lung-cancer cells 2
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... WASHINGTON and SAN DIEGO, March 17 Even ... sciences sector, industry,stakeholders are facing tough decisions, according ... crunch in the U.S., life science,organizations spanning biotechnology, ... access to capital and growing markets,compared to other ...
... March 17 Signalife, Inc. (Amex:,SGN - News) ... formal,purchase and financial commitments with respect to acquisitions ... commitments have,come internationally, including in Japan, other parts ... Dr. Harmison, the Company,s President and CEO, stated: ...
... HAVEN, Conn., March 17 VION,PHARMACEUTICALS, INC. (Nasdaq: ... and year-end of 2007., The Company reported a ... the year ended December 31, 2007, compared with a ... 2006. Weighted-average common shares,outstanding for the years ended December ...
Cached Biology Technology:Life Sciences Industry Reaches Crossroad Say Noted Pillsbury Attorneys 2Life Sciences Industry Reaches Crossroad Say Noted Pillsbury Attorneys 3Life Sciences Industry Reaches Crossroad Say Noted Pillsbury Attorneys 4Signalife Sees Accretive Purchase and Financial Commitments 2Vion Reports 2007 Fourth Quarter and Year-End Results 2Vion Reports 2007 Fourth Quarter and Year-End Results 3Vion Reports 2007 Fourth Quarter and Year-End Results 4
The Protein Kinase Factsbooks (2 Volume Set)...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Whole blood is collected from healthy pigs (mixed breed, either sex) at the time of slaughter, refrigerated within 6 hours, processed within 24 hours and frozen at -20ºC....
Human/Mouse/Rat Keap1 MAb (Clone 333116) Protein Family: Transcription Factor Regulators...
Biology Products: