Navigation Links
Human genes sing different tunes in different tissues
Date:11/2/2008

CAMBRIDGE, Mass. -- Scientists have long known that it's possible for one gene to produce slightly different forms of the same protein by skipping or including certain sequences from the messenger RNA. Now, an MIT team has shown that this phenomenon, known as alternative splicing, is both far more prevalent and varies more between tissues than was previously believed.

Nearly all human genes, about 94 percent, generate more than one form of their protein products, the team reports in the Nov. 2 online edition of Nature. Scientists' previous estimates ranged from a few percent 10 years ago to 50-plus percent more recently.

"A decade ago, alternative splicing of a gene was considered unusual, exotic but it turns out that's not true at all it's a nearly universal feature of human genes," said Christopher Burge, senior author of the paper and the Whitehead Career Development Associate Professor of Biology and Biological Engineering at MIT.

Burge and his colleagues also found that in most cases the mRNA produced depends on the tissue where the gene is expressed. The work paves the way for future studies into the role of alternative proteins in specific tissues, including cancer cells.

They also found that different people's brains often differ in their expression of alternative spliced mRNA isoforms.

Human genes typically contain several "exons," or DNA sequences that code for amino acids, the building blocks of proteins. A single gene can produce multiple protein sequences, depending on which exons are included in the mRNA transcript, which carries instructions to the cell's protein-building machinery.

Two different forms of the same protein, known as isoforms, can have different, even completely opposite functions. For example, one protein may activate cell death pathways while its close relative promotes cell survival.

The researchers found that the type of isoform produced is often highly ti
'/>"/>

Contact: Teresa Herbert
therbert@mit.edu
617-258-5403
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Similarities in imaging the human body, Earths crust focus of conference at UH
2. Researchers apply systems biology and glycomics to study human inflammatory diseases
3. UCSB study finds physical strength, fighting ability revealed in human faces
4. ICSU launches new program to understand the human impact on Earths life-support systems
5. Human protein atlas will help pinpoint disease
6. Genetic based human diseases are an ancient evolutionary legacy
7. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
8. Gene with probable role in human susceptibility to pulmonary tuberculosis identified
9. TheVisualMD.com launches new animated 3-D views of human body in action
10. Human Microbiome Project awards funds for technology development, data analysis and ethical research
11. Study: Bird diversity lessens human exposure to West Nile Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... The routine use of a molecular testing panel ... performing the correct initial surgery for patients with ... University of Pittsburgh Cancer Institute (UPCI), partner with ... Multidisciplinary Thyroid Center and other diagnostic testing agencies, ... initial surgery by 30 percent, according to the ...
(Date:7/24/2014)... loss leads to conflict among people around the world, ... (WCS) Health & Ecosystems: Analysis of Linkages (HEAL) Program ... to tackle global biodiversity decline. , The harvest of ... people and provides protein for more than a billion ... surprise that today,s unprecedented loss of wildlife, is bringing ...
(Date:7/24/2014)... use of native animal species for food or commercial ... significant factor in the decline of many species of ... indicates that more than half of the species being ... hornbills., "By surveying not only the meat made available ... inside the forest by hunters and brought to villages ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3New study draws links between wildlife loss and social conflicts 2
... 2013 As an expert in molecular genetics, Colin E. ... Medical Center,s Institute for Regenerative Medicine is to apply the ... human organs. But, with a background specifically in reproductive ... the over-population of homeless dogs and cats. Bishop has been ...
... provides the same quality of fuel for athletes as a ... nutrients that are more commonly found in animal products, according ... (IFT) Annual Meeting & Expo. The research was compiled ... He was unable to attend the meeting, so his presentation ...
... Health has awarded Virginia Commonwealth University a grant totaling ... work which may one day point researchers to ... inflammatory conditions such as rheumatoid arthritis, multiple sclerosis and ... by John Ryan, Ph.D., associate professor in the Department ...
Cached Biology News:Low-cost sterilization method for cats and dogs is focus of new research project 2Monitoring nutrient intake can help vegetarian athletes stay competitive 2VCU receives NIH grant to examine the biology of allergic disease 2
(Date:7/24/2014)... , July 24, 2014  ECC West Africa, LLC ... with University College Hospital (UCH) Ibadan Board ... project to finance, design, construct, and operate and maintain ... Nigeria . Under the first of the 4-phase ... documents and funding applications. UCH Ibadan intends to finance ...
(Date:7/24/2014)... Distinguished Professor of Engineering at the University of ... solve problems in energy engineering, environmental sustainability and ... zeolites, porous rock with a well-defined, crystalline structure. ... so precisely decided that zeolites can separate molecules ... an angstrom (one-tenth of a nanometer), making them ...
(Date:7/24/2014)... 24, 2014 Your cell phone ... modeling lithium-ion battery storage capacity. , New research ... theoretical model created at Lawrence Livermore National ... predicts how carbon components will perform as electrodes. ... the urgent need for higher-performance batteries. Several key ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2University of Delaware researcher describes new approach for creating organic zeolites 2Getting More Life out of Lithium-ion Batteries 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... Spanish . , Scientists at the University ... time different antioxidant compounds from foods such as olive oil, ... have used two new techniques, capillary electrophoresis and high resolution ... a great part of the phenolic compounds contained in these ...
... Dec. 8 Transgenomic, Inc. (OTC Bulletin Board: TBIO) announced ... first in a family of mutation detection kits the company ... ® HS DHPLC platform. SURVEYOR Scan technology is ... amplification reaction and hybridization to form heteroduplex DNA molecules in ...
... Dec. 8 PharmAthene, Inc. (NYSE Amex: PIP ) ... medical countermeasures against chemical and biological threats, announced today that ... Time, on Wednesday, December 9, 2009 to provide an update ... The dial-in number for U.S. callers is 866-383-8108 and for ...
Cached Biology Technology:New antioxidant compounds have been identified in foods such as olive oil, honey and nuts 2Transgenomic Announces the Commercial Launch of SURVEYOR(R) Scan K-RAS Mutation Detection Kit 2Transgenomic Announces the Commercial Launch of SURVEYOR(R) Scan K-RAS Mutation Detection Kit 3Transgenomic Announces the Commercial Launch of SURVEYOR(R) Scan K-RAS Mutation Detection Kit 4PharmAthene Announces Updated Time for Conference Call to Review BARDA rPA Decision 2
Tris-Hepes kit of BG-163 & BG-165 (order number BG-166)...
... ideal for both radioactive and nonradioactive labeling ... Provides five pre-mixed nucleotide solutions for flexibility ... 8 cpm/g control DNA using [-32P]-dCTP ... performance of the system Labels 1 ...
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
... Immunogen: Fusion protein derived from ... ASIP/PAR-3 (atypical PKC isotype-specific interacting protein/ ... not related to the protease-activated-receptors also ... Xenopus (positive controls: Caco-2 MDCK A6 ...
Biology Products: