Navigation Links
Human embryonic stem cells remain embryonic because of epigenetic factors
Date:10/4/2007

A human embryonic stem cell is reined in prevented from giving up its unique characteristics of self-renewal and pluripotency by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized tissue. But, thanks to the simultaneous presence of different protein modifications, stem cells are primed and poised, ready to develop into specialized body tissue, Singapore scientists reported in last months issue of the journal Cell Stem Cell.

The molecules central to this balancing act, H3K4me3 and H3K27me3, are among the so-called epigenetic modifications that influence the activity patterns of genes in both human embryonic stem (ES) cells and mature human adult cells.

Determining how ES cell genes are modified by these epigenetic markers may explain these cells unique characteristics, said the scientists, who are based at the Genome Institute of Singapore (GIS) and the Bioprocessing Technology Institute (BTI), both under the Agency for Science, Technology and Research (A*STAR), as well as at the National University of Singapore (NUS).

The scientists also discovered that genes modified only by one of the epigenetic markers, H3K4me3, contain the DNA recipes for proteins that enable an ES cell to proliferate, or duplicate itself. In the Cell Stem Cell paper, the scientists wrote, The prevalence of these genes may be related to the self-renewal property of ES cells.

The scientists also found that the genes that do not carry either of the two epigenetic modifications are completely silenced in ES cells. These genes, which are crucial to sensory processes, immunity, and drug metabolism, are active in highly specialized, mature adult cells.

Although epigenetic markers attach themselves to the tightly wound bundle of protein material called histones that package and compress the DNA in the nucleus of each human cell, they do not change the cells
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. Novel technology detects human DNA mutations
3. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
4. UWs Rosetta software to unlock secrets of many human proteins
5. Genome-wide mouse study yields link to human leukemia
6. Found: Missing sequence of the human Y chromosome
7. Study finds more than one-third of human genome regulated by RNA
8. Molecular machine may lead to new drugs to combat human diseases
9. Sea skate experiment sheds light on human cell transport
10. Mouse brain tumors mimic those in human genetic disorder
11. New Clues Add 40,000 Years to Age of Human Species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Coral Gables, Fla. (April 21, 2014) -- There are ... out their feathers and spread their colorful tails; satin ... them with blue and shiny objects; and European bitterling ... Each species has evolved a unique method to communicate ... "Signaling can have profound fitness ...
(Date:4/22/2014)... FL, April 22, 2014 Scientists from the Florida ... a protein complex that plays a critical but previously ... The study, which showed a novel role for a ... in the journal eLife , a publisher supported ... Society and the Wellcome Trust. , "This is a ...
(Date:4/22/2014)... Ltd.,s nanotechnology expert will present a poster ... the 7th International Nanotoxicology Congress to be ... Dr. Monita Sharma will outline a strategy consistent with ... Sciences, " Toxicity Testing in the 21st Century: A ... non-animal methods involving human cells and cell lines for ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3Scientists identify critical new protein complex involved in learning and memory 2
... jerks its head uncontrollably for no apparent reason. There ... people, most notably trigeminal neuralgia, and headshaking in horses. ... and treating the condition in horses, the pathology of ... A recent study led by academics ...
... PARSIPPANY, NJ (November 14, 2012) Parents may have some ... study, funded by Pinnacle Foods, Birds Eye brand and published ... to the plate led to more positive evaluations of both ... vegetables with dinner, participants believed the main course would taste ...
... lung cancer research team reports that lung cancer stem ... offering a new avenue for investigating immunotherapy treatment options ... Morris, MD, and his colleagues report their findings in ... , a peer-reviewed online publication that features original research ...
Cached Biology News:Study investigates headshaking in horses 2New study reveals more inspiring reasons to serve veggies at dinner 2Stem cell finding could advance immunotherapy for lung cancer 2
(Date:1/15/2014)... Hills, IL (PRWEB) January 15, 2014 ... to find hard-working items for the lab, from fluid ... as Guaranteed-in-Stock (GIS)—ready to ship when you order. ... Masterflex® Peristaltic Pumps , from the L/S® model for ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
(Date:1/15/2014)... 2013 was a banner year of ... They saw continued independent research led by the team ... a $1 million grant from the Susanne Marcus Collins ... a peer reviewed journal, Amy Grant highlighted Brainwave Optimization® ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... Twelve-Week Maintenance DosingBEERSE, Belgium, Jan. 22 ... a new class of biologics, has been approved by ... approved indication of ustekinumab is for the treatment of ... to respond to, or who have a contraindication to, ...
... Cell Innovations, Inc., (SCLL.PK) announced today that it has filed a new ... cells. , ... Houston, TX (PRWEB) January 22, 2009 -- Stem Cell ... application for the production of pluripotent stem cells from primordial germ cells. ...
... for testing the quality of a sperm before it ... conception. , Researchers at the University of Edinburgh, funded ... have created a way of chemically ,fingerprinting, individual sperm ... consider whether the sperm is healthy enough to be ...
Cached Biology Technology:New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis 2New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis 3New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis 4Stem Cell Innovations, Inc., Files New Patent Application 2Stem Cell Innovations, Inc., Files New Patent Application 3New sperm shaker to improve IVF success 2
... Microplate Handler is a high-capacity, plug-and-play ... BioTeks washers, readers and liquid handling ... ultimate flexibility and intuitive and powerful ... to single devices or linking several ...
XPLAC (S-17)...
Request Info...
ZBP-89 (S-15)...
Biology Products: