Navigation Links
Human embryonic stem cell secretions minimized tissue injury after heart attack
Date:9/9/2008

A novel way to improve survival and recovery rate after a heart attack was reported in the journal Stem Cell Research by scientists at Singapore's Institute of Medical Biology (IMB) and Bioprocessing Technology Institute (BTI) and The Netherlands' University Medical Center Utrecht.

This method, developed in laboratory research with pigs, is the first non-cell based therapeutic application of human embryonic stem cells (hESCs). It entails using secretions from stem cells.

In their studies with pigs, the researchers found that the administration of secretion from stem cells minimized heart injury by enhancing reperfusion therapy (angioplasty and cardiac bypass surgery) and reducing tissue death by another 60%.

Heart function was also markedly improved, the scientists report in the paper, published in the June 2008 issue of the journal.

By demonstrating the efficacy of this secretion in an experimental pig model, currently the best approximation to a human heart attack patient undergoing reperfusion therapy, the researchers say that they have addressed the longstanding problem of reperfusion injury in the most clinically relevant experimental setting.

"Using secretion instead of cells allows us to circumvent many highly intractable problems such as tumour formation, immune compatibility, cell viability, delivery, costs and timeliness," said IMB'S Dr Lim Sai Kiang, who leads the Singapore-The Netherlands collaboration.

Unlike the more common approach of directly administering stem cells for therapy, this new method carries negligible risk of tumour formation or rejection by the body.

In the pig research model, this approach minimised heart injury after a heart attack, a particularly important consideration since the heart has a limited ability to regenerate.

The research was carried out on pigs because it is the closest animal approximation to the human heart in terms of
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Leader of Human Genome Project honored with the Inamori Ethics Prize
2. Thumbs up -- a tiny ancestral remnant lends developmental edge to humans
3. Gene enhancer in evolution of human opposable thumb
4. Bisphenol A linked to metabolic syndrome in human tissue
5. Gene associated with pair-bonding in animals has similar effects in human males
6. Previous claims of siRNA therapeutic effects called into question by report in human gene therapy
7. Broad Institute awarded grant to develop chemical probes for human biology and disease
8. No more big stink: scent lures mosquitoes, but humans cant smell it
9. New giant clam species offers window into human past
10. Perfect pitch in humans far more prevalent than expected
11. CU-Boulder, biotech firm team up on python project in search for human cardiac therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... environment on Earth, but when the climate changes and ... limit. The amount of time needed to adjust to ... cope in the future, reveals a new study from ... scientific journal Proceedings of the Royal Society B ... levels of greenhouse gases in the atmosphere. The greenhouse ...
(Date:9/30/2014)... DURHAM, N.C. -- Pollution in urban and farm runoff ... a new study finds. , The study, published ... shows that nitrogen in the runoff ends up in ... tumors on the animals, eyes, flippers and internal organs. ... and the National Oceanic and Atmospheric Administration (NOAA) conducted ...
(Date:9/30/2014)... of Ludwig-Maximilians-Universitaet (LMU) in Munich report that a ... more sensitive to chemotherapeutic drugs. They have also ... new target for anti-tumor agents. , Researchers ... Stephan Sieber of the Technische Universitt Mnchen have ... potential new weapon in the fight against malignant ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Cancer therapy: Driving cancer cells to suicide 2
... Advancement of Science (AAAS) meeting in Washington, D.C., February ... from solar and renewable energy solutions to the latest ... president, will deliver the President,s Address at the opening ... Friday, February 18 ...
... affordable, high throughput DNA sequencing, coupled with improved bioinformatics ... the field of molecular plant breeding. Multidisciplinary breeding programs ... investigate genome-wide variations in DNA sequences and link them ... many genes, such as hybrid vigor. Furthermore, there has ...
... a method based on geographic positioning systems that allowed ... in a way similar to how geographers characterize mountain ... that reflects how "rugged" the surface of the tooth ... the shearing molars in insect eaters and omnivores to ...
Cached Biology News:Tip sheet: Caltech researchers presenting at AAAS 2Tip sheet: Caltech researchers presenting at AAAS 3UMass Amherst biologists use GPS to 'map' bats teeth to explore evolutionary adaptations to diet 2
(Date:9/30/2014)... Lyme Research Alliance (LRA), the ... at universities, today announced the awarding of seven grants ... and cure for Lyme and other tick-borne diseases. ... in its history—over 20 grant proposals—a 100 percent increase ... to receive so many solid applications from talented scientists ...
(Date:9/30/2014)... Windsor, CT (PRWEB) September 30, 2014 ... distributor of scientific research products, recently opened an ... its comprehensive cell culture product lines developed and ... through its online store include Biological Industries’ Nutristem® ... (hMSC) and human embryonic stem cell (hESC) culture. ...
(Date:9/30/2014)... 2014 UFP Technologies, a producer ... has recently introduced a custom insulated shipping container ... The new insulated shipper solves the issue of ... UFP Technologies’ BioShell is a universal storage container ... handling and shipping. The insulated shipper keeps frozen ...
(Date:9/30/2014)... Toronto, Ontario, Canada (PRWEB) September 30, 2014 ... requirements based on 500 square feet. per employee, which included ... different world back then.” says Jeff Howell, partner at ... tenant advisory firm in Toronto. “By the year 2000, ... We are now seeing that number come down to 175 ...
Breaking Biology Technology:Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3
... Telephone Corp. is opening a liason office with one ... campus. Hiroki Tanaka, vice president and general manager of ... seeking out opportunities for the company to expand further ... relationship during governor Jim Doyle's trade mission to Japan ...
... card American businesses have left to play if they ... and chief information officers must take the lead in ... Peters. , ,Peters spoke on Wednesday of the merits ... Wisconsin business executives during the Wisconsin Innovates Conference in ...
... Wis. Neurognostics Inc. said it has partnered ... combined functional magnetic resonance imaging software product. , ,"Both ... practice," said Doug Tucker, CEO of Neurognostics , ... collaborate on our efforts to develop clinically useful fMRI ...
Cached Biology Technology:Peters: Innovation the only edge that remains for American business 2
... EZ-Spread Plating Beads Sterile plating in ... glass rods and potentially hazardous ethanol flaming, ... choices of ready-to-use sterile packaging: dispenser bottle for ... plating, Fastest and easiest way to ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... a regulated environment, Pipette Tracker Pro ... that automates gravimetric pipette calibration and ... meets todays regulatory compliance requirements. Pipette ... that includes a full security implementation, ...
... the yolk protein Vtg in plasma from juvenile ... biomarker for endocrine disrupting chemicals (EDCs) with estrogenic ... an accepted screening test for the estrogenic effects ... EIA kit is a double-antibody immunometric (sandwich) EIA ...
Biology Products: