Navigation Links
Human derived stem cells can repair rat hearts damaged by heart attack
Date:8/26/2007

then purifying the cells, they were able to turn about 90 percent of stem cells into cardiomyocytes.

The researchers dealt with the other big challenge of stem cell death by implanting the cells along with a cocktail of compounds aimed at helping them grow. The cocktail included a growth "matrix"-- a sort of scaffolding for the cells to latch on to as they grow -- and drugs that block processes related to cell death. When using the pro-growth cocktail, the success rate of heart muscle grafts improved drastically: 100 percent of rat hearts showed successful tissue grafts, compared to only 18 percent in grafts without the cocktail.

"The problem of cell death is pretty common in stem-cell treatments," Murry explained. "When we try to regenerate with liquid tissues, like blood or bone marrow, we're pretty good at it, but we haven't been very successful with solid tissues like skeletal muscle, brain tissue, or heart muscle. This is one of the most successful attempts so far using cells to repair solid tissues -- every one of the treated hearts had a well-developed tissue graft."

When the researchers followed up on the stem-cell treatment by taking images of the rat hearts, they found that the grafts helped thicken the walls that normally stretch out after a heart attack and cause the heart to weaken. The thickened walls were also associated with more vigorous contraction.

"We found that the grafts didn't just survive in the rat hearts -- they also helped improve the function of the damaged heart," said Dr. Michael Laflamme, UW assistant professor of pathology and the lead author of the study. "That's very important, because one of the major problems for people suffering a myocardial infarction is that the heart is damaged and doesn't pump blood nearly as well. This sort of treatment could help the heart rebound from an infarction and retain more of its function afterwards."

The next step in studying stem-cell treatments f
'/>"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. Novel technology detects human DNA mutations
3. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
4. UWs Rosetta software to unlock secrets of many human proteins
5. Genome-wide mouse study yields link to human leukemia
6. Found: Missing sequence of the human Y chromosome
7. Study finds more than one-third of human genome regulated by RNA
8. Molecular machine may lead to new drugs to combat human diseases
9. Sea skate experiment sheds light on human cell transport
10. Mouse brain tumors mimic those in human genetic disorder
11. New Clues Add 40,000 Years to Age of Human Species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... KNOXVILLEToday,s students in college biology and other science ... in quantitative ways, and now they have a ... for the Life Sciences," published this month by ... National Institute for Mathematical and Biological Synthesis (NIMBioS), ... that can be used to explore and explain ...
(Date:8/19/2014)... A team of UTSA researchers has been awarded a ... Technology and Training (NCPTT), an office of the National ... The grant will fund a one-year study of the ... of historic homes in hot, humid climates. , Radiant ... or attics that reflect heat back, thereby reducing the ...
(Date:8/19/2014)... to humans and animals in a number of ways. ... them to regrow entire organs. After being struck by ... entire crown. But there is one major downside to ... to the habitats in which they live and therefore ... to this dilemma, plants have developed mechanisms that enable ...
Breaking Biology News(10 mins):New textbook introduces undergraduates to mathematics for the life sciences 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3How steroid hormones enable plants to grow 2
... million people in 36 countries of sub-Saharan Africa are ... African sleeping sickness. The disease is caused by organisms ... African sleeping sickness affects approximately 500,000 people in sub-Saharan ... Because the trypanosome has an exceptional genetic strategy for ...
... headed by Professor Hans-Georg Kräusslich at Heidelberg University ... Applied Tumor Virology of the Deutsches Krebsforschungszentrum (German ... to label Human Immunodeficiency Viruses (HIV) for visual ... virus. , The labeling permits scientists to observe ...
... virologists headed by Professor Hans-Georg Kräusslich at Heidelberg ... of Applied Tumor Virology of the Deutsches Krebsforschungszentrum ... first to label Human Immunodeficiency Viruses (HIV) for ... the virus. , The labeling permits scientists to ...
Cached Biology News:Newly discovered protein an important tool for sleeping sickness research 2New Species of Coral Discovered Off Southern California 2Virologists make major step towards understanding the process of HIV infection 2
(Date:8/19/2014)... -- Research and Markets  has announced the addition of the ... report to their offering. This report analyzes ... Thousands by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , ... Latin America . Annual estimates and forecasts are provided for ...
(Date:8/19/2014)... Cellgen Diagnostics today launched ... a corporate lab for its genetic-based medical testing ... a critical component in the move from today’s ... of personalized medicine – a more predictive, preventive, ... contributions will support Cellgen’s intent to develop the ...
(Date:8/19/2014)... 19, 2014 Robin Williams’ passing is ... take on an individual. Symptoms range from slowness ... problems swallowing and severe depression. Parkinson’s disease progressively ... of dopamine producing neurons of the brain. As ... that slowly and progressively gets worse, they look for ...
(Date:8/19/2014)... 19, 2014 Research and ... the "Spectroscopy Equipment and Accessories - ... their offering. This report ... and Accessories in US$ Thousands by the ... Raman Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) ...
Breaking Biology Technology:Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2
... worked for almost seven years in secret. , Most ... Goehner,s materials characterization department at Sandia National Laboratories was ... containing bacillus anthracis, the spores that cause the disease ... 2001 to several news media offices and to two ...
... in the nanocrystals of semiconductors to cool more slowly ... the potential to improve satellite communications and the generation ... these electronsin this case, by more than 30 timescould ... Guyot-Sionnest, Professor of Chemistry and Physics at the University ...
... Nov. 13 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) ... &,Company, LLC,s Focus on Infectious Disease Conference on Thursday, ... at the Needham and Company,LLC,s office in New York ... Officer of Anadys,will present an overview of Anadys and ...
Cached Biology Technology:FBI unveils science of anthrax investigation 2FBI unveils science of anthrax investigation 3New research expected to improve laser devices and make photovoltaics more efficient 2Anadys Pharmaceuticals to Present at the Needham Focus on Infectious Disease Conference 2
... TriEx Sf9 Cells and TriEx Insect Cell ... pTriEx baculovirus constructs. This cell/medium combination has ... growth and high protein expression levels observed ... vectors. Please note that our Ready-Plaque Sf9 ...
...
...
...
Biology Products: