Navigation Links
Human derived stem cells can repair rat hearts damaged by heart attack
Date:8/26/2007

When human heart muscle cells derived from embryonic stem cells are implanted into a rat after a heart attack, they can help rebuild the animal's heart muscle and improve function of the organ, scientists report in the September issue of Nature Biotechnology. The researchers also developed a new process that greatly improves how stem cells are turned into heart muscle cells and then survive after being implanted in the damaged rat heart. The findings suggest that stem-cell-based treatments might one day help people suffering from heart disease, the leading cause of death in most of the world.

The study was conducted by researchers at the University of Washington School of Medicine in Seattle and at Geron Corp. in Menlo Park, Calif. The scientists set out to tackle two of the main challenges to treating damaged hearts with stem cells: the creation of cardiac cells from embryonic stem cells, and the survival of those cells once they are implanted in a damaged heart.

"Past attempts at treating infarcted hearts with stem cells have shown promise, but they have really been hampered by these challenges," explained Dr. Chuck Murry, director of the Center for Cardiovascular Biology in the UW Institute for Stem Cell and Regenerative Medicine, and corresponding author on the study. "This method we developed goes a long way towards solving both of those problems. We got stem cells to differentiate into mostly cardiac muscle cells, and then got those cardiac cells to survive and thrive in the damaged rat heart."

Embryonic stem cells can differentiate, or turn into, any type of cell found in the body. But researchers had struggled to get stem cells to differentiate into just cardiomyocytes, or heart muscle cells -- most previous efforts resulted in cell preparations in which only a fraction of 1 percent of the differentiated cells were cardiac muscle cells. By treating the stem cells with two growth factors, or growth-encouraging proteins, and
'/>"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. Novel technology detects human DNA mutations
3. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
4. UWs Rosetta software to unlock secrets of many human proteins
5. Genome-wide mouse study yields link to human leukemia
6. Found: Missing sequence of the human Y chromosome
7. Study finds more than one-third of human genome regulated by RNA
8. Molecular machine may lead to new drugs to combat human diseases
9. Sea skate experiment sheds light on human cell transport
10. Mouse brain tumors mimic those in human genetic disorder
11. New Clues Add 40,000 Years to Age of Human Species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... 2013) The AGA Research Foundation announced a new ... between the gut microbiota, one of today,s most exciting ... , The AGA Research Awards Panel selected Andrew T. ... Hospital and Harvard Medical School, Boston, as the 2013 ... will receive $25,000 of funding, commencing in July 2013, ...
(Date:5/17/2013)... the white noise of the South, but the night belongs ... air hangs heavy from the humidity and the sounds of ... species of frogs, toads and salamanders, is the center of ... swamps are the auditorium for their symphonic choruses, the scientists ... or ARMI, have front-row seats. , Amphibians, which ...
(Date:5/17/2013)... State University of New Jersey, and City University of ... Visikol TM that effectively clears organisms to be ... of chloral hydrate, which is one of the few ... regulated by the Drug Enforcement Administration (DEA) due to ... clearing agents, are vital for viewing organisms under a ...
Breaking Biology News(10 mins):New gut microbiome research to explore red meat -- colorectal cancer pathway 2Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3
... signs of climate change in the upper atmosphere and ... Tyler Prize for Environmental Achievement. The award, ... will go to Richard Alley, professor of geosciences at ... atmospheric and climate sciences in the Scripps Institution of ...
... French and Spanish . , The ... projects assembled from researchers in more than 60 countries. Launched ... March 2009 to allow for observations during the alternate seasons ... ICSU, IPY spearheaded efforts to better monitor and understand the ...
... University of Delaware researchers have won the American Physical ... orthopedics published in 2008. Their study focused on ... management of anterior cruciate ligament (ACL) injuries. Each ... which is one of the major ligaments of the ...
Cached Biology News:Winners of Tyler environmental prize announced 2Polar research reveals new evidence of global environmental change 2Polar research reveals new evidence of global environmental change 3Researchers win award for best clinical paper in orthopedic physical therapy 2
(Date:5/16/2013)... 16, 2013 Scientists at the Center for ... , and the California -based biopharmaceutical ... novel therapy for reversing memory decline in mice with ... significant cognitive improvement in advanced stage AD mice. The ... reversing cognitive decline for advanced stage AD mice, and ...
(Date:5/16/2013)... 16, 2013 Reportlinker.com announces ... is available in its catalogue: ... Analysis: Therapeutic Proteins – Biosimilars, Biobetters ...   Product ... The new Competitive Intelligence Report Therapeutic ...
(Date:5/16/2013)... ON (PRWEB) May 16, 2013 DNA Genotek, ... announced ‘Spit for Africa’, a sponsorship program in conjunction with ... is designed to improve access and reduce the cost of ... projects such as the Human Heredity and Health in Africa ... the AfSHG. , The aim of the AfSHG ...
(Date:5/16/2013)... May 16, 2013 Leading UK ... Success for Companion Diagnostic–Drug Pairings in Oncology, a ... biopharmaceutical manufacturers should understand when developing new drug-test ... particularly in oncology, with two recently approved drug–test ... BRAF-mutation positive melanoma. Payors are willing to consider ...
Breaking Biology Technology:Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8DNA Genotek Inc. Announces Spit for Africa Program 2DNA Genotek Inc. Announces Spit for Africa Program 3Market Access Expert Firm, PRMA Consulting, Launches Companion Diagnostics Handbook 2
... /Xinhua-PRNewswire/ -- Olympus Capital Holdings Asia and,its co-investors ... to,sell Arysta LifeScience Corporation, the world,s largest privately ... value of,approximately JPY 250 billion (US$2.2 billion). The ... a leading middle market private,equity firm with investment ...
... Calif., Oct. 22 AMDL, Inc. (Amex:,ADL), ... Shenzhen,Jiangxi and Jilin, China, through its wholly ... international biopharma company that,engages in the development, ... products. AMDL announced today that its,management will ...
... Investigating New Cases of Chagas, Disease ... Bites & Blood Transfusions, ANAHEIM, Calif., Oct. 20 ... licensed the first blood-screening test,for Chagas, disease, some 241 blood ... to the parasite known to cause,this serious and potentially fatal ...
Cached Biology Technology:Olympus Capital Announces Agreement to Sell Arysta LifeScience Corporation 2Olympus Capital Announces Agreement to Sell Arysta LifeScience Corporation 3AMDL to Present its China Success Story at Rodman & Renshaw 9th Annual Healthcare Conference 2Blood Donations in U.S. Testing Positive for Chagas' Disease 2Blood Donations in U.S. Testing Positive for Chagas' Disease 3Blood Donations in U.S. Testing Positive for Chagas' Disease 4
... Highly nutritious peptone, ... the production of bacterial ... cultivation of bacteria with ... Corynbacterium, Haemophilus, Neisseria, Pasteurella, ...
... in Minimum Essential Medium (Eagle) with 2 mM ... growth. In order to keep the antigens ... acetone-methanol. The cells are arrayed on a ... wells surface specifically treated to enhance cellular attachment ...
... cells were cultured in Ham's F12K medium with ... phase of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on a ... wells surface specifically treated to enhance cellular attachment ...
... cultured in Minimum Essential Medium (Eagle) with 2 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
Biology Products: