Navigation Links
Human beta cells can be easily induced to replicate, according to study in Diabetes
Date:1/13/2009

PITTSBURGH, Jan 13 Researchers at the University of Pittsburgh School of Medicine have successfully induced human insulin-producing cells, known as beta cells, to replicate robustly in a living animal, as well as in the lab. The discovery not only could improve models and methods for studying diabetes, but also opens up new possibilities for treating the condition.

"Most scientists thought that these important pancreatic cells could not be induced to regenerate, or could only replicate very slowly," explained senior author Andrew F. Stewart, M.D., professor of medicine and chief of the Division of Endocrinology and Metabolism at the University of Pittsburgh School of Medicine. "This work provides proof-of-principle that the production of human beta cells can be stimulated, and that the newly generated cells function effectively both in the lab and in a living animal."

The findings are in the early online version of Diabetes, one of the journals of the American Diabetes Association.

Lead authors Nathalie Fiaschi-Taesch, Ph.D., assistant professor in Pitt's endocrinology division, and Todd A. Bigatel, M.D., a graduate of the postdoctoral fellowship program, identified molecules that play key roles in human beta, or islet, cell replication, building on previous work conducted by co-author Irene Cozar-Castellano, Ph.D., also an instructor of endocrinology, who performed similar studies using mouse cells.

They found that, unlike rodents, human beta cells contain a significant amount of a protein called cdk-6. When cdk-6 production was increased using a viral vector carrying the cdk-6 gene, the cells replicated. Stimulation was further enhanced by increasing production of another cell cycle molecule called cyclin D1. Untreated human islets did not replicate.

"After we transplanted some of these engineered human beta cells under the outer layer of a kidney in a diabetic mouse, we saw that replication continued and b
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. As super-predators, humans reshape their prey at super-natural speeds
2. Primate culture is just a stones throw away from human evolution, study finds
3. Human genomics in China
4. Understanding extinct microbes may influence the state of modern human health
5. New use for human hair
6. Neural mechanisms of value bias in the human visual cortex
7. Biomedical researchers create artificial human bone marrow in a test tube
8. African thicket rat malaria linked to virulent human form
9. Snails and humans use same genes to tell right from left
10. VistaGen, WARF sign license agreement for human embryonic stem cell technology
11. Scientists study how asbestos fibers trigger cancer in human cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2015)... June 15, 2015 A new report ... reveals the majority of US consumers using mobile banking applications ... such as fingerprint and voiceprint, instead of having to prove ... to Telstra,s " Mobile Identity   -   The Fusion ... with smartphones now the primary channel used by Gen X ...
(Date:6/11/2015)... , June 11, 2015 Daon, a ... today that its IdentityX Mobile Authentication Platform v4.0 ... Online) Alliance is an industry consortium launched in ... for simpler, stronger authentication.  In order to receive ... a rigorous series of tests that measure compliance ...
(Date:6/9/2015)... June 09, 2015 Research and Markets ... the "Gesture Recognition & Touchless Sensing Market ... Automotive, & Others), Product (Biometric & Sanitary Equipment) ... report to their offering. The ... expected to reach $ 23.55 Billion by 2020 ...
Breaking Biology News(10 mins):One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2
... scientific conference devoted primarily to osteoporosis, will open on ... on four key topics in nutrition and bone health. ... Epidemiology Resource Centre at the University of Southampton; and ... of Oxford, will speak on the developmental origins of ...
... whose moist permeable skins make them susceptible to slight ... impending alterations in biodiversity during rapid climate change. ... predictive power of this sensitive group of animals in ... birds. The study appears this week in the advance ...
... schizophrenia, major depression and cancer are not caused ... A novel computational biology method developed by a ... http://www.njit.edu/news/2008/2008-367.php , associate professor in NJIT,s department of ... to uncover the critical genes responsible for disease ...
Cached Biology News:Nutrition and bone health session to open the IOF World Congress on Osteoporosis in Bangkok 2Study confirms amphibians' ability to predict changes in biodiversity 2NJIT professor finds engineering technique to identify disease-causing genes 2
(Date:7/1/2015)... , July 1, 2015   Decision ... frequently cited advantages of Otezla are its oral ... profile, as reported by surveyed rheumatologists. Otezla was ... for the treatment of active psoriatic arthritis in ... current standard of care includes conventional oral treatments ...
(Date:7/1/2015)... , July 1, 2015   Neuraltus Pharmaceuticals, ... development of groundbreaking drugs to treat neurodegenerative diseases ... that Robert G. Miller , M.D., Director of ... Health,s California Pacific Medical Center in San Francisco, has ... for $1.5 million to help fund a Phase ...
(Date:7/1/2015)... ... 01, 2015 , ... A newly launched business plan contest will ask startup ... innovation in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see ... a period of expert mentorship from a senior industry figure drawn from the Pistoia ...
(Date:7/1/2015)... , ... July 01, 2015 , ... ... to combat pathogen transmission. CTI’ new Medical Joysticks have an impermeable molecular ... now have an operator control device that will increase healthcare worker safety and ...
Breaking Biology Technology:Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2
... GPRO ) announced today that the Company will ... 31, 2008 at approximately,4:00 p.m. Eastern Time (ET). The ... p.m. ET. Hank Nordhoff, chairman and chief,executive officer, and ... will host the call., The conference call will ...
... merit and part of its overall strategy to, cripple PSC, force PSC to ... for failing to provide funding to ... PSC., -- ... FDA approval for its lead vaccine product, FluBlok, ...
... , - 1st Half-Year Sales Up 16%, - Revision Upwards of 2008 Sales Growth Guidance: (greater than or equal,to)12%, EUR millions ... 2008 08/07 ... ... 20.5 72 23.2 72 13 26.8 71 15 ...
Cached Biology Technology:Gen-Probe Announces Webcast of Second Quarter 2008 Earnings Conference Call 2Protein Sciences Responds to Emergent BioSolutions Lawsuit 2Protein Sciences Responds to Emergent BioSolutions Lawsuit 3Protein Sciences Responds to Emergent BioSolutions Lawsuit 4Protein Sciences Responds to Emergent BioSolutions Lawsuit 5Stallergenes: Q2 2008 Sales up 18% Revision Upwards of 2008 Sales Growth 2
... Normal;heading 1;heading 2;Many ... and experimental situations ... standard transfection and ... systems. ViraPower Lentiviral ...
...
See product name for description....
... This volume provides excellent background ... the study of major HIV proteins including: ... H, integrase and protease. Expression of HIV ... and Rev assays; HIV/CD4 interactions; transient assays ...
Biology Products: