Navigation Links
'Hulk' protein, Grb10, controls muscle growth
Date:8/30/2012

Bethesda, MD Scientists have moved closer toward helping people grow big, strong muscles without needing to hit the weight room. Australian researchers have found that by blocking the function of a protein called Grb10 while mice were in the womb, they were considerably stronger and more muscular than their normal counterparts. This discovery appears in the September 2012 issue of The FASEB Journal. Outside of aesthetics, this study has important implications for a wide range of conditions that are worsened by, or cause muscle wasting, such as injury, muscular dystrophy, Type 2 diabetes, and problems produced by muscle inflammation.

"By identifying a novel mechanism regulating muscle development, our work has revealed potential new strategies to increase muscle mass," said Lowenna J. Holt, Ph.D., a study author from the Diabetes and Obesity Research Program at the Garvan Institute of Medical Research in Sydney, Australia. "Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes."

To make this discovery, Holt and colleagues compared two groups of mice. Once group had disruption of the Grb10 gene, and were very muscular. The other group, where the Grb10 gene was functional, had normal muscles. Researchers examined the properties of the muscles in both adult and newborn mice and discovered that the alterations caused by loss of Grb10 function had mainly occurred during prenatal development. These results provide insight into how Grb10 works, suggesting that it may be possible to alter muscle growth and facilitate healing, as the processes involved in muscle regeneration and repair are similar to those for the initial formation of muscle.

"Don't turn in your gym membership just yet," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "If you want big muscles, the classic prescript
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hulk smash? Maybe not anymore: scientists block excess aggression in mice
2. Groundbreaking discovery of mechanism that controls obesity, atherosclerosis
3. New study discovers powerful function of single protein that controls neurotransmission
4. MicroRNA controls malignancy and resistance of breast cancer cells
5. Cone snail venom controls pain
6. Salk scientists open new window into how cancers override cellular growth controls
7. Researchers identify key culprit causing muscle atrophy
8. Embryonic blood vessels that make blood stem cells can also make beating heart muscles
9. Study identifies how muscles are paralyzed during sleep
10. Robot vision: Muscle-like action allows camera to mimic human eye movement
11. Searching for the origin of muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... May 6, 2015 LifeBEAM, a developer of ... producer, announced today that they will expand their partnership ... first bio-sensing cycling helmet and the first joint project ... new colors in order to give cyclists more style ... addition, LifeBEAM and Lazer announced their plan to release ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... N.Y. Some cellular proteins have multiple, and occasionally ... colleagues at Cold Spring Harbor Laboratory demonstrate in a ... [link: to paper via doi #] that the oncogenic ... growth and prevent cancerous proliferation by stabilizing p53, the ...
... The official Kickoff meeting of the Building ... by the Museum fr Naturkunde , Berlin, took place ... the project and to set goals and objectives for the ... of EU BON,s framework with the Global Earth Biodiversity ...
... new article published in the Journal of Paleontology ... describe the most diverse group of fossilized green lacewing ... who value them in organic pest control, for their ... relatives to these insects are most diverse in southeastern ...
Cached Biology News:A cancer-promoting protein is found to also suppress cell growth 2The large-scale EU project EU BON: Towards integration with its global counterpart GEO BON 2
(Date:5/28/2015)... , May 28, 2015 ... ) has announced the addition of Jain ... - Technologies, Markets, and Companies" to ... , This report deals with ... aimed at improving patient care by monitoring ...
(Date:5/28/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/l9dqwt/animal_genetics ) has announced the ... by Testing services - Global Forecast to 2020" ... genetics market is estimated to be worth around $2.5 ... 8-9% during the forecast period of 2014 to 2020 ... animal protein consumption, increasing adoption of advanced genetic technologies ...
(Date:5/28/2015)... N.J. , May 28, 2015 Celsion ... that it has received commitments from two institutional healthcare ... of the Company,s common stock in an at-the-market registered ... to purchase common stock. The Company entered ... to which the Company agreed to sell an aggregate ...
(Date:5/28/2015)... 2015  PDS Biotechnology Corp. announces preliminary data ... HPV-16, has generated strong T-cell responses in pre-cervical ... is treated by surgical removal of lesions however, ... alternative. Results show that it primes and activates ... and kill precancerous and cancerous cells that display ...
Breaking Biology Technology:Global Therapeutic Drug Monitoring Market 2015-2024 2Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 3PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy 2
... May 14, 2012   USHIFU, LLC (US HIFU), a ... ultrasound (HIFU) technologies, announced today that Mark Carol, ... chief development officer. With more than 25 years ... Dr. Carol will focus on continued development of ...
...  /PRNewswire-Asia/ -- 3SBio Inc. (NASDAQ: SSRX ) ("3SBio" ... on researching, developing, manufacturing and marketing biopharmaceutical products, today ... ended March 31, 2012. First ... net revenues increased by 24.5% over the first quarter ...
... at Nanyang Technological University (NTU), it comes in the form of ... kills them without the need for antibiotics. The killer coating, ... and fungi that it comes in contact with, is now being ... specialising in animal care products. The next step is ...
Cached Biology Technology:US HIFU Adds Mark Carol, MD, As Chief Development Officer 2US HIFU Adds Mark Carol, MD, As Chief Development Officer 3US HIFU Adds Mark Carol, MD, As Chief Development Officer 43SBio Inc. Announces Unaudited First Quarter 2012 Results 23SBio Inc. Announces Unaudited First Quarter 2012 Results 33SBio Inc. Announces Unaudited First Quarter 2012 Results 43SBio Inc. Announces Unaudited First Quarter 2012 Results 53SBio Inc. Announces Unaudited First Quarter 2012 Results 63SBio Inc. Announces Unaudited First Quarter 2012 Results 73SBio Inc. Announces Unaudited First Quarter 2012 Results 83SBio Inc. Announces Unaudited First Quarter 2012 Results 93SBio Inc. Announces Unaudited First Quarter 2012 Results 103SBio Inc. Announces Unaudited First Quarter 2012 Results 11NTU scientists invent superbug killers 2NTU scientists invent superbug killers 3
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... Rapid-Screen cDNA Library Panels were designed for ... sets of PCRs to identify the desired ... performed in a 96-well "Master Plate," where ... clones. Having identified the positive well(s) by ...
... the macro- and micronutrients as ... (1962) and the vitamins as ... (1968). Preparation Quantity Equivalency: Formulated ... powder per liter of medium. ...
Biology Products: