Navigation Links
'Hulk' protein, Grb10, controls muscle growth
Date:8/30/2012

Bethesda, MD Scientists have moved closer toward helping people grow big, strong muscles without needing to hit the weight room. Australian researchers have found that by blocking the function of a protein called Grb10 while mice were in the womb, they were considerably stronger and more muscular than their normal counterparts. This discovery appears in the September 2012 issue of The FASEB Journal. Outside of aesthetics, this study has important implications for a wide range of conditions that are worsened by, or cause muscle wasting, such as injury, muscular dystrophy, Type 2 diabetes, and problems produced by muscle inflammation.

"By identifying a novel mechanism regulating muscle development, our work has revealed potential new strategies to increase muscle mass," said Lowenna J. Holt, Ph.D., a study author from the Diabetes and Obesity Research Program at the Garvan Institute of Medical Research in Sydney, Australia. "Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes."

To make this discovery, Holt and colleagues compared two groups of mice. Once group had disruption of the Grb10 gene, and were very muscular. The other group, where the Grb10 gene was functional, had normal muscles. Researchers examined the properties of the muscles in both adult and newborn mice and discovered that the alterations caused by loss of Grb10 function had mainly occurred during prenatal development. These results provide insight into how Grb10 works, suggesting that it may be possible to alter muscle growth and facilitate healing, as the processes involved in muscle regeneration and repair are similar to those for the initial formation of muscle.

"Don't turn in your gym membership just yet," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "If you want big muscles, the classic prescription still applies: lift heavy things, eat and sleep right, and have your hormones checked. But this study shows that when we understand the basic science of how muscle fibers grow and multiply, we will be able to lift the burden literally of muscle disease for many of our patients."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Hulk smash? Maybe not anymore: scientists block excess aggression in mice
2. Groundbreaking discovery of mechanism that controls obesity, atherosclerosis
3. New study discovers powerful function of single protein that controls neurotransmission
4. MicroRNA controls malignancy and resistance of breast cancer cells
5. Cone snail venom controls pain
6. Salk scientists open new window into how cancers override cellular growth controls
7. Researchers identify key culprit causing muscle atrophy
8. Embryonic blood vessels that make blood stem cells can also make beating heart muscles
9. Study identifies how muscles are paralyzed during sleep
10. Robot vision: Muscle-like action allows camera to mimic human eye movement
11. Searching for the origin of muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2016)... , 19 de diciembre de 2016  Mosaic Biomedicals SL anunció ... acelerado de MSC-1, un anticuerpo humanizado que se espera comenzar a ... con múltiples sitios previstos a lo largo de Europa y Norteamérica. ... MSC-1 es el ... de leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa en ciertos ...
(Date:12/15/2016)... , Dec. 15, 2016   WaferGen Bio-systems, ... held genomics technology company, announced today that on December ... Qualifications Department of The Nasdaq Stock Market LLC which ... bid price of WaferGen,s common stock had been at ... WaferGen has regained compliance with Listing Rule 5550(a)(2) of ...
(Date:12/12/2016)... Dec. 12, 2016  Researchers at Trinity College, ... graphene by combining the material with Silly Putty. The ... pressure detector able to sense pulse, blood pressure, ... spider.  The research team,s findings ... read here:  http://science.sciencemag.org/content/354/6317/1257 ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... 2017   Bracket , a leading clinical trial ... of Jennifer Peters to its growing team ... Manager for the Scientific Services division. In this role, ... Rater Training, Quality Assurance, and Electronic Clinical Outcomes Assessments ... and demonstrated record building technology-based businesses in life sciences. ...
(Date:1/24/2017)... ... January 24, 2017 , ... Men ... serum leptin levels had a positive association with increased prostate growth or benign ... the International Neurourology Journal involved 571 Korean men who underwent urological examinations, ...
(Date:1/24/2017)... ... 2017 , ... The Foundation for Food and Agriculture Research, ... career nominees for the 2017 New Innovator in Food and Agriculture Research Award. ... in which one in nine people suffers from hunger. The Foundation for Food ...
(Date:1/24/2017)... 2017   Instrument Business Outlook ( ... MN ) the 2016 Company of the ... newsletter tracking developments in the analytical and life ... consistently achieved outstanding technical, operational and financial results ... of IBO. "In 2016, Bio-Techne capitalized on opportunities ...
Breaking Biology Technology: