Navigation Links
HudsonAlpha and UAB researchers work to identify optimal treatments for ER+ breast cancer
Date:8/1/2013

HUNTSVILLE, Ala. The most commonly diagnosed form of breast cancer, termed estrogen receptor positive or ER+, accounts for the largest percentage of breast cancer deaths each year. Research by scientists at the HudsonAlpha Institute for Biotechnology and the University of Alabama at Birmingham Comprehensive Cancer Center aims to provide physicians a more targeted approach to treating ER+ breast cancer.

"Can we find something in the genome that correlates with those patients who respond to treatment as opposed to those who do not?" posed Rick Myers, Ph.D., president and director of HudsonAlpha. Myers, principal investigator on the nearly $1 million grant recently awarded by Susan G. Komen for the Cure, said researchers have an unprecedented opportunity to identify molecular signatures that could mean faster, more effective treatments.

Myers, along with Katherine Varley, Ph.D., at HudsonAlpha, and Andres Forero, M.D., and Don Buchsbaum, Ph.D., of the UAB Comprehensive Cancer Center, will evaluate the genetic composition of breast cancer cells obtained from an investigator initiated trial that combined two medications; one that blocks estrogen action and the other a monoclonal antibody that blocks formation of vessels in the tumors. The patients with ER+ breast cancer participating in the trial provided biopsy specimens from primary tumors prior to treatment and at six weeks after the initiation of therapy. Physicians and scientists at UAB, including Forero and Buchsbaum, led the clinical trial.

"The trial involved a unique combination of drugs," said Myers, "and some women responded well to the treatment and others did not. With this Komen award, we will use new technologies to examine all the genes the entire genomes in the tumor tissues from the women who participated, in hopes of identifying molecular signatures specific for those who respond versus those who do not respond." Physicians could then use these signatures, or bi
'/>"/>

Contact: Holly Ralston
hralston@hudsonalpha.org
256-508-8954
HudsonAlpha Institute for Biotechnology
Source:Eurekalert

Page: 1 2

Related biology news :

1. HudsonAlpha awarded grant to improve diagnoses of childhood genetic disorders
2. UPCI researchers target cell sleep to lower chances of cancer recurrence
3. U-M researchers land $2M grant to cooperate with nature on growing algae for energy
4. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
5. Researchers uncover cellular mechanisms for attention in the brain
6. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
7. U of M researchers unveil nations first porcine virus rapid detection test
8. Researchers reveal the clearest new pictures of immune cells
9. Researchers describe potential for MERS coronavirus to spread internationally
10. U of M researchers identify new functions for autoimmune disease risk gene
11. Solving DNA puzzles is overwhelming computer systems, researchers warn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ...
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the travel experience ... borders. Over the past decade, ePassports, biometric readers, and ... process through border control via eGates and Automated Passport ... seaports, and land borders across the globe. ...
(Date:12/11/2014)... 2014 Research and Markets , ... has announced the addition of the "Biometrics Market ... One major trend emerging in this ... technology, it is important to upgrade biometric solutions to ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... --- How do children reason about the natural world? ... non-human animals? For decades, the consensus was that ... they adopt an "anthropocentric" stance, favoring humans over non-human ... animals. But Northwestern University researchers have taken ...
... Southhampton and Cambridge Universities in the UK have presented ... in stronger hip bones. The results were presented at ... Italy. More than 200 six-year olds participated in ... bone mass and analysed the structure of the femoral ...
... as environmentally friendly sources of renewable energy, but which ... on developing? A new study involving researchers from North ... chemicals react when burned. Their data and new computer ... and technologies to maximize energy efficiency while minimizing environmental ...
Cached Biology News:Animals talk, sing and act like humans? 2Study paves way for new biofuels models, technologies 2
(Date:1/22/2015)... NH (PRWEB) January 22, 2015 GEA ... a table top laboratory homogenizer, the PandaPLUS 2000, which ... nanodispersions, nanoemulsions , and cell disruption . This ... dairy products, fruit juices, liquid food, food additives and ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... BioLife Solutions, Inc.,(OTC Bulletin Board: BLFS), a ... storage and cryopreservation media products for cells,tissues, ... joined the Biomedical,Excellence for Safer Transfusion (BEST) ... and commercial partners whose,mission is to explore ...
... AlloSource, one of the nation,s largest non-profit providers of ... surgical procedures, will this year sponsor one of the ... in the January 1 Tournament of Roses Parade(R). The ... to the millions of people touched by organ, tissue ...
... California (USC) have, for the first time in history, derived ... will enable scientists to create far more effective animal models ... , The research will be published in the Dec. 26 ... is a major development in stem cell research because we ...
Cached Biology Technology:BioLife Solutions Joins Prestigious Biomedical Excellence for Safer Transfusion Collaborative 2BioLife Solutions Joins Prestigious Biomedical Excellence for Safer Transfusion Collaborative 3AlloSource, Tissue Recipient Join 'Stars of Life' Affected by Organ and Tissue Donation Aboard Donate Life Float in 2009 Rose Parade(R) 2AlloSource, Tissue Recipient Join 'Stars of Life' Affected by Organ and Tissue Donation Aboard Donate Life Float in 2009 Rose Parade(R) 3USC researchers derive first embryonic stem cells from rats 2USC researchers derive first embryonic stem cells from rats 3
... Multi-Disciplinary Team The Schleicher & ... stand-alone work center dedicated to custom ... The facilitys experienced project teams, comprised ... Marketing professionals, work closely with collaborators ...
... for proteomic scale kinase profiling, quantitative ... drug discovery research built on the ... synthesis platform. These microarrays are available ... Kinase Substrate - Peptide Microarray Service. ...
... is a commonly used technique for studying ... are electrophoresed on SDS-PAGE and transferred to ... where they are probed with specific antibodies. ... reuse of Southern and Northern blots, it ...
... Microarrays designed for immunological studies, vaccine ... the flexible and powerful Paraflo microfluidic ... available as part of our comprehensive ... Custom Probe Content Probe content ...
Biology Products: