Navigation Links
HudsonAlpha and UAB researchers work to identify optimal treatments for ER+ breast cancer
Date:8/1/2013

HUNTSVILLE, Ala. The most commonly diagnosed form of breast cancer, termed estrogen receptor positive or ER+, accounts for the largest percentage of breast cancer deaths each year. Research by scientists at the HudsonAlpha Institute for Biotechnology and the University of Alabama at Birmingham Comprehensive Cancer Center aims to provide physicians a more targeted approach to treating ER+ breast cancer.

"Can we find something in the genome that correlates with those patients who respond to treatment as opposed to those who do not?" posed Rick Myers, Ph.D., president and director of HudsonAlpha. Myers, principal investigator on the nearly $1 million grant recently awarded by Susan G. Komen for the Cure, said researchers have an unprecedented opportunity to identify molecular signatures that could mean faster, more effective treatments.

Myers, along with Katherine Varley, Ph.D., at HudsonAlpha, and Andres Forero, M.D., and Don Buchsbaum, Ph.D., of the UAB Comprehensive Cancer Center, will evaluate the genetic composition of breast cancer cells obtained from an investigator initiated trial that combined two medications; one that blocks estrogen action and the other a monoclonal antibody that blocks formation of vessels in the tumors. The patients with ER+ breast cancer participating in the trial provided biopsy specimens from primary tumors prior to treatment and at six weeks after the initiation of therapy. Physicians and scientists at UAB, including Forero and Buchsbaum, led the clinical trial.

"The trial involved a unique combination of drugs," said Myers, "and some women responded well to the treatment and others did not. With this Komen award, we will use new technologies to examine all the genes the entire genomes in the tumor tissues from the women who participated, in hopes of identifying molecular signatures specific for those who respond versus those who do not respond." Physicians could then use these signatures, or bi
'/>"/>

Contact: Holly Ralston
hralston@hudsonalpha.org
256-508-8954
HudsonAlpha Institute for Biotechnology
Source:Eurekalert

Page: 1 2

Related biology news :

1. HudsonAlpha awarded grant to improve diagnoses of childhood genetic disorders
2. UPCI researchers target cell sleep to lower chances of cancer recurrence
3. U-M researchers land $2M grant to cooperate with nature on growing algae for energy
4. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
5. Researchers uncover cellular mechanisms for attention in the brain
6. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
7. U of M researchers unveil nations first porcine virus rapid detection test
8. Researchers reveal the clearest new pictures of immune cells
9. Researchers describe potential for MERS coronavirus to spread internationally
10. U of M researchers identify new functions for autoimmune disease risk gene
11. Solving DNA puzzles is overwhelming computer systems, researchers warn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... June 22, 2015 ... addition of the "Huawei Ascend Mate 7 ... to their offering. Huawei,s technological choice ... opposite direction than Apple,s and Samsung,s one. The ... developed by Fingerprint Cards, a main actor in ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, a ... authentication solutions, today announced enhanced functionality of its ... solution.  The enhancements build on the native ... DigitalPersona Altus platform and provide expanded mobile ... In today,s environment of increasing cyber-attacks ...
(Date:6/17/2015)... , June 17, 2015  Synaptics Inc. ... interface solutions, today announced that Xiaomi, one of ... Synaptics ® ClearPad ® family of ... driver integrated circuits (DDICs) for its latest smartphones, ... leveraging ClearPad for full in-cell display solutions and ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... JOLLA, CA--The Salk Institute for Biological Studies and Columbia ... grant by The Leona M. and Harry B. Helmsley ... use of induced pluripotent stem (iPS) cells to gain ... therapeutic drugs. "Stem cell research is of immense ...
... 2010) A new partnership among several regional ... Central Appalachians for using stable isotopes to study ... terrestrial and aquatic ecosystems. With the opening of ... the University of Maryland Center for Environmental Science ...
... The Federation of American Societies for Experimental Biology ... announced the travel award recipients for the 2010 American ... DC from November 2-6, 2010. These awards are ... postdoctorates and scientists into the mainstream of the basic ...
Cached Biology News:Helmsley Charitable Trust awards more than $15 million to Salk Institute-CUMC 2Helmsley Charitable Trust awards more than $15 million to Salk Institute-CUMC 3New regional facility opened to advance stable isotope research in central Appalachians 2
(Date:7/2/2015)... ... July 02, 2015 , ... Sleepless nights will become ... quality of sleep, launched its Indiegogo campaign on June 23. Sound sleepers and the ... technology makes it effortless to use, while the integration of the Bluetooth speaker, alarm ...
(Date:7/1/2015)... N.C. and PARIS ... firm AgBiome, and Genective, key developer of biotech ... the discovery of new generations of insect control ... insect control to counter the realities of advancing ... Genective, aligning AgBiome,s unique insect control technology with ...
(Date:7/1/2015)... and BANGALORE, India , July ... profiling company that uses next generation sequencing technology to ... Scott A. Storrer as chief executive officer. In ... will be responsible for all strategy, business expansion and ... who has served as Strand,s chairman and CEO since ...
(Date:7/1/2015)... July 1, 2015 Isagenix International, a leading ... three Gold, three Silver, and three Bronze Stevie® Awards ... in Chicago this month.The ... business awards program in the U.S. ... strength in developing leaders, cultivating talent, creating a unified ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3AgBiome and Genective collaborate to create novel insect-resistant crops 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3
... ... 16 HS System for use by laboratories participating in or generating DNA records for the ... ... System for use by laboratories participating in, or generating DNA records for, the National ...
... DUBLIN, November 24 Shire plc (LSE: SHP,NASDAQ: ... has submitted a MAA to the European Medicines Agency for,velaglucerase ... of Type 1 Gaucher disease. This is the third marketing,application ... the United States and Canada. , ...
... , BOZEN, Italy, November 24 ... new Canadian joint venture with a group of selected,investors. ... Health Robotics Canada, Inc. and will market, install, and ... includes the,revolutionary product offerings i.v.STATION(TM), i.v.SOFT(TM), and OMM(TM).,Health Robotics ...
Cached Biology Technology:NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 4Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 3
Phenytoin-BSA Isolated IgY DFc Drug...
Tropomyosin 4 [Tm4]...
Mouse monoclonal [2A4] to Cytokeratin 8 + 18 + 19 ( Abpromise for all tested applications). Antigen: Cytokeratins isolated from cultured pig kidney epithelial cells. Entrez GeneID: 3856 S...
Anti-human Carcinoma Associated Antigen, Clone 115D8, Monoclonal Antibody Innate Immunity - Tumor Markers...
Biology Products: