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How zinc starves lethal bacteria to stop infection
Date:11/11/2013

s. The smaller size of zinc means that when it binds to the transporter, the mechanism closes too tightly around the zinc, causing an essential spring in the protein to unwind too far, jamming it shut and blocking the transporter from being able to take up manganese.

"Without manganese, these bacteria can easily be cleared by the immune system," says Dr McDevitt. "For the first time, we understand how these types of transporters function. With this new information we can start to design the next generation of antibacterial agents to target and block these essential transporters."


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Contact: Dr Christopher McDevitt
christopher.mcdevitt@adelaide.edu.au
61-449-823-946
University of Adelaide
Source:Eurekalert

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