Navigation Links
How yeast chromosomes avoid the bad breaks
Date:8/7/2011

it's always been very confusing why you would break your genome. It's your blueprint," says Hochwagen. "Obviously, it helps you make new variations and combinations of genes, but it's incredibly dangerous and you really need to make sure that it happens the right way."

In repetitive DNA, this system of breaking and swapping is particularly hazardous, as there are many options that a section of repeat DNA could be swapped with. If the wrong repeat is chosen, a chromosome can gain or lose a large chunk of DNA. In humans, such mistakes have been linked to genetic neurological and developmental disorders, including autism spectrum disorders and schizophrenia.

By studying the highly repetitive DNA that makes up yeast's ribosomal DNA (rDNA), Gerben Vader and Hannah Blitzblau, first authors of the Nature paper and postdoctoral researchers in Hochwagen's lab, have determined that yeast's rDNA is protected from inappropriate recombination by two mechanisms. It was previously shown that heterochromatin prevents chromosome breakage in repetitive DNA. But in their paper, Vader and Blitzblau demonstrate that, ironically, the protective heterochromatin renders the transition zone between the repetitive and non-repetitive DNA particularly fragile. The yeast cell buttresses these borders with Pch2 and Orc1, which prevent chromosome breakage across the entire transition zone. In their absence, rDNA frequently gains or loses repeats.

"We had previously seen very little chromosome breakage in large regions close to repetitive DNA," says Blitzblau. "The finding that the borders of heterochromatin are particularly fragile helps us to understand why the cell invests in specifically protecting these regions."

Although the modes of heterochromatin formation vary between organisms, similar strategies may be at work in higher organisms, too.

"In mice and flies repetitive DNA is also packaged into heterochromatin, and there is evidence that very
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers tap yeasts as source of green surfactants
2. Novel gene increases yeasts appetite for plant sugars
3. Cellular stress can induce yeast to promote prion formation
4. Shuttle Atlantis to launch with yeast
5. Dietary yeast extracts tested as alternative to antibiotics in poultry
6. Maquipucuna cloud forest in Ecuador yields new species of yeast
7. Heat shock protein drives yeast evolution
8. Green genes in yeast may boost biofuel production by increasing stress tolerance
9. Tracking down pathogenic yeasts
10. Flower-dwelling yeast licensed for use against scab disease
11. Guardian of the genome: Protein helps prevent damaged DNA in yeast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... OXFORD, Conn. , Apr. 1, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... number of Wocket smart wallets is underway to early ... early access group includes usage at retail outlets including ... CVS Pharmacy. Users report Wocket was accepted at all ...
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... world,s first controlled study of a comprehensive genetic screening test ... twin girls born in Germany in June and a singleton ... in a pilot study of comparative genomic hybridisation (CGH) by ... a full range of chromosomal disorders. Dr Cristina ...
... Rivers and streams supply the lifeblood of ecosystems across the ... well as a wide array of life forms in rivers ... the fish humans eat. But humans and nature itself are ... role to support fish species, according to new research by ...
... global energy demands is the use of Poplar, a ... the most out of Poplar plantations, varieties that are ... or higher yields, for exampleare desired. But do these ... populations of Poplar? In particular, is the genetic makeup ...
Cached Biology News:First babies born from genetic screening study 2First babies born from genetic screening study 3A river ran through it 2A river ran through it 3A river ran through it 4The risks and benefits of using poplars for biofuels 2
(Date:4/27/2015)... 27, 2015  For about a century, a ... ability to utilize and catabolize glucose at a ... is called the ,Warburg phenomenon", that is an ... oxygen presence, leading to enhanced lactate generation. Even ... choose glucose fermentation. A variety of such abnormalities ...
(Date:4/27/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... year ended December 31, 2014. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... provide the outcome management and investors had hoped ... Therapeutics", said Andrew Rae , President & ...
(Date:4/27/2015)... HEIDELBERG , Alemania, April 27, 2015 ... patente para un nuevo receptor utilizando tecnología de descubrimiento ... no cubierta en el tratamiento de millones de pacientes ... anunciado hoy que ha recibido una patente en Europa ... el descubrimiento de Molecular Health de que EPHB4 es ...
(Date:4/27/2015)... Calif. (PRWEB) April 27, 2015 Dr. ... drug and chemical toxicity carries implications for advancing the ... April 28 at National University , the second-largest ... presentation by Dr. Hanzlik, a professor at the University ... metabolism and drug design, starts at 5 p.m. and ...
Breaking Biology Technology:Study Indicates Cancer Cells Alter Glucose Metabolism to Enhance Energy Production and Cell Growth 2iCo Therapeutics Announces Year End 2014 Financial Results 2iCo Therapeutics Announces Year End 2014 Financial Results 3iCo Therapeutics Announces Year End 2014 Financial Results 4Molecular Health obtiene la patente para un nuevo receptor 2Molecular Health obtiene la patente para un nuevo receptor 3Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3
... BOSTON, Jan. 11, 2012  CBI, a division of Advanstar ... 11th Annual Patient Adherence Forum, which is being held ... in Philadelphia, PA. At the event, industry experts share ... through stakeholder collaboration and patient engagement.  ...
... 11, 2012 What:  Come view ... CES, and hear Lucier and Rothberg discuss the future of ... http://photos.prnewswire.com/prnh/20110216/MM49339LOGO ) When:   Wednesday, ... Where:   Las Vegas Convention Center, North Hall, Booth ...
... 11, 2012  Inovio Pharmaceuticals, Inc. (NYSE Amex: INO ), which ... Dr. J. Joseph Kim, President and CEO, will present an overview of ... Noble Financial 8th Annual Equity Conference January ...   Inovio Presentation Tuesday, ...
Cached Biology Technology:Complete Agenda Announced for 11th Annual Patient Adherence Forum 2Inovio Pharmaceuticals to Present at Noble Financial 8th Annual Equity Conference 2Inovio Pharmaceuticals to Present at Noble Financial 8th Annual Equity Conference 3
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
... Goat anti-Human Alpha 1 Acid ... azide Goats were immunized ... glycoprotein in Freund's adjuvant. ... absorbed to ensure specificity. ...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Request Info...
Biology Products: