These researchers have also shown that dietary energy balance alters signaling through the Akt and mTOR pathways, both of which are related to TPA-mediated skin tumor development. They propose that the mechanism for the effect of dietary energy balance on Akt and mTOR signaling may be mediated, in part, by changes in serum IGF-1 levels, which then alters signaling through the IGF-1R and EGFR.
"These findings will provide the basis for future translational studies targeting the Akt/mTOR pathway via combinations of lifestyle (e.g., moderate calorie restriction regimens) and pharmacologic approaches for the prevention and control of obesity-related epithelial cancers in humans," said John DiGiovanni, Ph.D., director of M. D. Anderson Cancer Center Science Park Research Division, in whose lab this work is being conducted.
The effect of in utero folic acid supplementation on colorectal cancer in the offspring in a chemical carcinogenic rodent model: Abstract 2098
Although folic acid fortification has proven to lower rates of neural tube defects and some childhood cancers, there is a growing body of evidence that too much folic acid may increase ones risk of developing colorectal cancer. A new study suggests that folic acid supplementation provided in utero, but not postnatally, may protect offspring from developing colorectal cancer.
This study provides important insights into the critical role of timing of folic acid intervention in colorectal cancer development and progression. Folic acid may prevent new cancers in the colorectum, said Karen K. Sie, a graduate medical student at the University of Toronto.
The University of Toronto research team had previously demonstrated that folic acid supplementation could promote the progression of the earliest precursor to colorectal cancer. This study focused on whether or not folic acid supplementation i
|Contact: Staci Vernick Goldberg|
American Association for Cancer Research