Dietary energy balance refers to the balance between caloric intake and energy expenditure, according to the report. Previous findings from both epidemiological and experimental studies suggest chronic positive energy balance, which can lead to obesity, increases the risk of developing multiple cancers. However, a negative energy balance state, as induced by calorie restriction, decreases these risks in most instances, the researchers said.
In the present study, the researchers used a two-stage skin carcinogenesis model to examine the effects of both positive and negative dietary energy balance on skin tumor promotion and progression. Groups of female mice received 25 nmol of 7,12-dimethylbenz(a)anthracene (DMBA), a cancer inducing chemical, and were then placed on one of four dietary treatment regimens to generate either a positive or negative energy balance state. After four weeks on their respective diets, the mice received two other cancer inducing chemicals (acetone, 3.4 nmol or 6.8 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA)) twice weekly for the duration of the study.
Negative energy balance, as induced by both 15 percent and 30 percent calorie restriction, led to inhibition of papilloma (benign skin tumors that can potentially lead to skin cancer) formation, depending on TPA dose, when compared to either positive energy balance inducing diet. Although tumor multiplicity, as measured by papillomas per mouse, was slightly higher among those receiving the more calorie dense fat diet, this was not different from the less calorie dense fat diet with either dose of TPA, the researchers noted. The impact of dietary energy balance manipulation on the conversion of papillomas to squamous cell carcinomas in this model of multistage
|Contact: Staci Vernick Goldberg|
American Association for Cancer Research