Within the rs1614972 sequence, the variant form of the gene offered a protective effect against breast cancer that varied inversely proportional with the drinking level. The more alcohol women drank, the less protective the effect and the higher their risk of developing breast cancer.
Marian cautions that the work needs to be explored further and replicated by other studies, as the research showed these sequence variations were associated with increased risk of breast cancer but were not necessarily biologically responsible for this effect.
These two genes encode for enzymes involved in the metabolization of alcohol, so variations in these genes can increase or decrease the rate of alcohol metabolism, Marian said. We have to keep in mind that the gene sequence variations we observed are not located directly in coding regions, but they may be associated and inherited together with other variations that have this effect on the enzyme function.
Dietary energy balance modulates multistage epithelial carcinogenesis in mouse skin: Abstract 1604
New data suggest that dietary energy balance may affect the risk for skin tumor development. Researchers believe that these effects of dietary energy balance are mediated by changes in signaling through the epidermal growth factor receptor (EGFR) and the insulin-like growth factor 1 receptor (IGF-1R).
We have demonstrated that dietary energy balance directly modulates activation of cell surface receptors, specifically the EGFR and the IGF-1R, which subsequently affects signaling through downstream pathways, such as Akt and mTOR. Negative energy b
|Contact: Staci Vernick Goldberg|
American Association for Cancer Research