Association Between ADH1B and ADH1C Haplotype Tag SNPs and Breast Cancer Risk, and the Interaction with Alcohol Drinking: Abstract 5814
Specific variations within two genes involved with alcohol metabolism are associated with an increased risk for breast cancer in postmenopausal women, according to a new study.
The work, conducted by research groups led by Peter Shields, M.D., professor of medicine and oncology at Georgetown Universitys Lombardi Comprehensive Cancer Center and Jo Freudenheim, Ph.D., chair of social and preventive medicine at the State University of New York at Buffalo, indicates that sequence variations within the genes
ADH1B and ADH1C may as much as double a postmenopausal woman drinkers risk for breast cancer.
We found that variations in two genes coding for the alcohol dehydrogenase enzyme increase the risk of breast cancer among women who drink, said lead author Catalin Marian, M.D., Ph.D., a research instructor of cancer genetics and epidemiology at Georgetown. The higher their alcohol consumption, the higher their risk.
Marian and colleagues evaluated data from participants in the Western New York Exposure and Breast Cancer (WEB) Study, a population-based case-control study of breast cancer conducted by Freudenheim in women ages 35 to 79 from two western New York counties between 1996 and 2001. Women with primary, histologically confirmed breast cancer served as cases. Healthy control participants were randomly selected and matched to cases by age, race and county of residence.
The research team analyzed DNA samples taken from 991 women with breast cancer and 1,698 controls. They found that variations within the DNA sequences rs1042026 in the gene ADH1B and rs1614972 in the gene ADH1C were associat
|Contact: Staci Vernick Goldberg|
American Association for Cancer Research