Navigation Links
How the wrong genes are repressed: New finding from UCL
Date:6/11/2010

The mechanism by which 'polycomb' proteins critical for embyronic stem cell function and fate are targeted to DNA has been identified by UCL scientists.

The discovery, which has implications for the fields of stem cell and tissue engineering, is detailed in research published today in the journal Molecular Cell.

A key feature of stem cells is the suppression of genes that when later switched on lead to the differentiation of the cells into specific mature cell types, such as neurons or immune cells. Polycomb proteins, first discovered in fruit flies, are known to play a critical role in the suppression of these developmental genes. PRC2 (polycomb repressive complex-2) is present in all multicellular organisms and has been shown to be important in stem cell differentiation and early embryonic development.

The study authors found that PRC2 is brought to its target genes though binding to a new class of short RNAs transcribed by RNA polymerase II. PRC2 can then methylate chromatin, preventing the activation of developmental regulator genes that would otherwise act to alter the identity of the cell.

Senior author Dr Richard Jenner, UCL Infection & Immunity, said: "We knew that different sets of genes are turned on in different cells and that polycomb proteins prevent the wrong genes from being turned on, for example polycomb prevents the activation of neuronal genes in immune cells. However, although polycomb proteins repress genes, they are actually in a poised state some sort of gene activity seemed to be occurring.

"We wanted to find out what this activity was and our identification of these short RNAs explains this unusual gene state. Discovering that polycomb also binds to these RNAs shows how polycomb might be recruited to genes, which are then repressed to maintain the identities of different cell types. This has been a key question in the field for some time and has important implications for how w
'/>"/>

Contact: Ruth Howells
ruth.howells@ucl.ac.uk
44-207-679-9739
University College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Doctors may be giving the wrong dosage of adrenaline in an emergency because of labelling
2. Darwin was wrong about the wild origin of the chicken
3. Study shows Darwin was wrong about the origins of chickens
4. Are existing large-scale simulations of water dynamics wrong?
5. Princeton scientists find way to catalog all that goes wrong in a cancer cell
6. Gene regulation, not just genes, is what sets humans apart
7. Interaction of just 2 genes governs coloration patterns in mice
8. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
9. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
10. Smoking turns on genes -- permanently
11. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... research, involving mice and published in the October 2014 ... , suggests that just because you can do ... team of Italian scientists have found that using marijuana ... immune system. This damage may result in autoimmune diseases ... bowel disease and rheumatoid arthritis in adulthood. , "I ...
(Date:9/30/2014)... MILFORD, Mass. , Sept. 30, 2014 ... process control solutions for the biotech and ... of its new RECONN Bioprocess Manager, an ... reporting solution geared towards bioprocess development laboratories. ... facilities have disparate bioreactor and analyzer systems. ...
(Date:9/29/2014)... A new study confirms that the exposure to tar ... than of regular cigarettes. Similarly, exposure to nicotine ... increasingly popular type of cigarette in several countries around ... of certain toxic chemicals in the smoke of these ... because lower levels of chemicals in the smoke are ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2
... Hall of Fame quarterback Dan Marino and VitaCore Health ... specific nutritional supplements based on authentic sciences. Marino joined ... develop health products that will strongly impact how consumers ... specifically in terms of their joints, heart, wellbeing, endurance, ...
... The stories they could tell, these fishes that once swam ... In the 1960s and ,70s, Richard Rosenblatt, a marine ... on field expeditions to remote places to study the fishes ... waters, Rosenblatt and other scientists retrieved hundreds of specimens of ...
... (BRONX, NY) Scientists at Albert Einstein ... a desktop genome analyzer and browser that allows biologists ... data. The open-source software, called GenPlay, is described in ... genomic data is analyzed mainly by information specialists rather ...
Cached Biology News:Dan Marino Teams up with VitaCore Health Products 2Dan Marino Teams up with VitaCore Health Products 3'Library of Fishes' to feature thousands of specimens from remote locations 2'Library of Fishes' to feature thousands of specimens from remote locations 3Einstein offers easy-to-use genome analyzer to scientific community 2
(Date:9/30/2014)... This news release is available in German . ... photonic crystal around several quantum dots in a semiconductor layer. ... a consequence of atomic processes. If a short laser pulse ... modified and the quantum dot experiences a change in the ... slow down the emission of light by the dot. As ...
(Date:9/30/2014)... , Sept. 30, 2014 Pacific Northwest ... Summary Global Markets Direct,s, ,Pacific Northwest ... provides an overview of the Pacific Northwest Biotechnology, ... report provides comprehensive information on the current therapeutic ... with comparative analysis at various stages, therapeutics assessment ...
(Date:9/30/2014)... Over the last decade, the laboratory filtration market ... and increased acceptance of new filtration technologies in end ... are also catalyzing the growth of laboratory filtration market. ... grow at a strong CAGR during the forecast period ... million by 2019. The market is mainly driven by ...
(Date:9/30/2014)... 30, 2014 CORD:USE Cord Blood Bank – ... it has entered into an Equity and Exclusive Services ... licensed a series of patented technologies for the isolation of ... applications.  Tianhe is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... , , WASHINGTON , Jan. 27 ... which are increasingly used for research and therapeutic interventions, but extracting ... have found evidence that fat tissue, known as adipose tissue, may ... called hematopoietic stem and progenitor cells (HSPCs), according to a ...
... , , , , , , ... Biologic,Products, Inc. (Nasdaq: CBPO ) ("China Biologic," or the "Company"), ... responded to,allegations regarding the Company, certain members of its Board of ... online,financial websites. , The article, which was ...
... Obtain Stem Cells From Embryos , WHITE PLAINS, N.Y. ... reprogrammed adult cells into embryonic-like stem cells has been chosen to receive ... Shinya Yamanaka , MD, PhD, of the Gladstone Institute of Cardiovascular Disease, ... will be honored with the 2010 March of Dimes Prize for his ...
Cached Biology Technology:Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 2Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 3Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 4China Biologic Products Responds to Allegations on Financial Websites 2China Biologic Products Responds to Allegations on Financial Websites 3China Biologic Products Responds to Allegations on Financial Websites 4China Biologic Products Responds to Allegations on Financial Websites 5March of Dimes Awards $250,000 Prize to Scientist Who Discovered How to Reprogram Human Cells 2
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
...
...
... in conjuction with Annexin V-FITC to distinguish ... of apoptosis (Annexin V positive, PI negative) ... of apoptosis or already dead (Annexin V-FITC ... the orange range of the spectrum using ...
Biology Products: