Navigation Links
How the hat fits: Structural biology study reveals shape of epigenetic enzyme complex
Date:1/20/2011

To understand the emerging science of epigeneticsa field that describes how genes may be regulated without altering the underlying DNA itselfscientists are deciphering the many ways in which enzymes act on the proteins surrounding DNA within cells.

One type of these enzymes, proteins known as histone acetyltransferases (HATs), act on DNA by modifying DNA-bound proteins called histones. This act of modification, called acetlyation, can dictate how histones interact with DNA and other proteins affecting processes such as DNA replication, transcription (reading the gene), and repair. In the February 9 issue of the journal Structure, available online, researchers at The Wistar Institute are the first to describe the complete atomic structure formed by a yeast HAT, known as Rtt109, and one of its associated proteins. Their findings demonstrate how a particular histone acetylation event works, a crucial step to understanding epigenetics and the related processes that underlie both health and disease.

According to the study's senior author, Ronen Marmorstein, Ph.D., professor and program leader of Wistar's Gene Expression and Regulation Program, two copies of Rtt109 bind to two copies of a "chaperone" protein to form a ring.

"The ring fits atop a histone much like a halo, and we find that the type of chaperone dictates exactly how the enzyme affects the histone by determining the exact position of acetylation," said Marmorstein. "The structure represents a nice model system for the regulation of protein acetylation, and teaches us something new about the biology of this enzyme, Rtt109."

The act of acetylation adds an "acetyl group," a small chemical structure, to a lysineone of the amino acids that make up a given protein. Altering one lysine could change the shape of a protein, such as a histone, in a subtle way, perhaps redirecting how it functions. Rtt109, the researchers say, acetylates any of three specific lysines on hi
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Structural biology scores with protein snapshot
2. National Science Foundations awards grant to Oklahoma structural biology group
3. National Science Foundation awards grant to Oklahoma structural biology group
4. University of Nevada professor studies structural basis for autism disorders
5. Structural defects precede functional decline in heart muscle
6. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
7. Structural Genomics Consortium releases 1,000th protein structure
8. Structural genomics accelerates protein structure determination
9. MRI scans show structural brain changes in people at risk for Alzheimers disease
10. Blood pressure control system found in kidneys structural units
11. Illuminating biology: An evolutionary perspective
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the hat fits: Structural biology study reveals shape of epigenetic enzyme complex
(Date:8/12/2015)... 2015  New research unveiled at Black Hat ... to steal users, fingerprints. Information released today by ... scanners on mobile devices, making the security of ... on mobile devices, HYPR Corp. recently released a ... systems with strong cryptographic security. More information on ...
(Date:8/10/2015)... 2015 The latest 364 page report ... of the global border security market . Visiongain ... in 2015. Now: Border security is hard to ... the business critical issue you need to know about - ... objective analysis of how this will impact your company and ...
(Date:8/5/2015)... August 5, 2015 According to ... Management Market by Software, Services, Vertical (BFSI, Airport, IT & ... - Global Forecast to 2020", published by MarketsandMarkets, defines ... globally into various segments. The global PIAM Market is ... $546.2 Million by 2019, at a CAGR of 14.9 ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... , This release is available in ... the US and Europe harbour more plant species than ... closer related to each other and often share similar ... environmental impacts than rural ecosystems. This is concluded by ...
... Strasbourg 18/04/12 - Technology has transformed the way humans interact ... big ideas that will drive growth in marine and maritime ... and policy will gather at the 3rd Marine Board Forum ... Marine Board has convened this flagship event on the understanding ...
... Lugano-CH/Aurora-US-CO/Geneva-CH, 18 April 2012 -- New techniques for identifying ... screening, a nanotech ,nose, and a method to examine ... according to presentations at the 3rd European Lung Cancer ... lung cancer is vital to improve lung cancer survival ...
Cached Biology News:Live fast, die young 2New technologies for a blue future 2Early detection techniques offer hope for improved outcomes in lung cancer patients 2Early detection techniques offer hope for improved outcomes in lung cancer patients 3Early detection techniques offer hope for improved outcomes in lung cancer patients 4
(Date:8/27/2015)... ... August 27, 2015 , ... ... venture capital funds, investment firms and animal health companies to hear from animal ... $160 million. Several have also received licensing agreements or distribution contracts. This ...
(Date:8/27/2015)... LANSING, Mich. , Aug. 27, 2015  Neogen ... has acquired the stock of United Kingdom ... supplier of microbiological culture media and diagnostic systems. ... has grown into a leading provider of microbial testing ... and clinical testing markets. The company currently sells into ...
(Date:8/27/2015)... CELEBRATION, Fla. , Aug. 27, 2015 ... announced that a patient,s eyes—and life—were saved by doctors ... , working with NNFF, NovaBay Pharmaceuticals and Dr. ... Wound Care Center at Seton Medical Center in ... The successful treatment used a breakthrough approach, pioneered by ...
(Date:8/27/2015)... , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... and six-month periods ended June 30, 2015. Biorem,s complete second quarter ... ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended ... 2014 , 2015 , 2014 Revenue ... , 4,433 Gross profit , 1,656 , ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Neogen acquires U.K.-based Lab M Holdings 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3
... 10, 2011 AWAC, an inVentiv Health company, and ... enabled medical management solutions, announced today that it has ... The new name and organization – unveiled today ... Phoenix, Arizona – better reflects the company,s expanded solutions, ...
... With the decreasing cost and ... cost-effective sample preparation pipeline for targeted sequencing.  To ... sample preparation throughput to the ever increasing throughput ... ROG; OTCQX: RHHBY) announces the imminent launch ...
... Scientists at deCODE Genetics and academic collaborators from ... the discovery of low frequency variants in the human genome ... and serum uric acid levels.  The study was done in ... online edition of Nature Genetics . Using ...
Cached Biology Technology:AWAC Becomes inVentiv Medical Managementâ„¢ 2Roche NimbleGen Announces New Pre-capture Multiplexing for Target Enrichment Technology in Sequencing 2Roche NimbleGen Announces New Pre-capture Multiplexing for Target Enrichment Technology in Sequencing 3deCODE Genetics, in Collaboration with Academic Colleagues and Illumina, Discovers Two Rare Variants that Affect the Risk of Gout and Serum Uric Acid Levels 2deCODE Genetics, in Collaboration with Academic Colleagues and Illumina, Discovers Two Rare Variants that Affect the Risk of Gout and Serum Uric Acid Levels 3
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Tissue culture grade....
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
IHC detection kit for PCNA in cells and tissues...
Biology Products: