Navigation Links
How the demons of dementia possess and damage brain cells
Date:3/3/2010

A study from EPFL's (Ecole Polytechnique Fdrale de Lausanne) Laboratory of Neuroenergetics and Cellular Dynamics in Lausanne Switzerland, published today in the Journal of Neuroscience, may lead to new forms of treatment following a better understanding of how Amyloid-Beta found in cerebral plaques, typically present in the brain of Alzheimer's patients, may lead to neurodegeneration. Researchers in Lausanne have studied how the functions of certain cells called astrocyteswhich normally protect, repair, and transfer energy to neuronsare impaired when "possessed" by aggregated Amyloid-Beta.

Alzheimer's disease currently affects more than 26 million people worldwide and estimates of up to four times as many sufferers by 2050 has made studying its causes a top priority for neuroscientists.

While the exact mechanisms by which the formation of plaques occurs and how they cause neurodegeneration and dementia is still a matter of debate in the scientific world, this study sheds a new light on how astrocytes may participate in the development of Alzheimer's disease. This new understanding of the interaction between Amyloid-Beta and astrocytes could lead to more effective therapies for Alzheimer's disease by trying to rescue astrocytic functions by deactivating the scavenger receptors.

The current study explores the causal relationship between the build-up of the Amyloid-Beta protein, associated with the formation of plaques, and the impairment of astrocyte's functions. Pierre Magistretti, director of the Brain Mind Institute and the Center for Psychiatric Neurosciences at CHUV/UNIL, and Igor Allaman, post doctoral fellow in Magistretti's lab, have succeeded in determining how built-up Amyloid-Beta infiltrates the astrocyte cells and alters their proper functioning, thus leading to the death of surrounding neurons. "To penetrate the astrocyte, the pathological protein goes through a 'scavenger' receptor." explains Igor Allaman. "Our
'/>"/>

Contact: Michael Mitchell
michael.mitchell@epfl.ch
41-798-103-107
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing
2. Researchers demonstrate nanoscale X-ray imaging of bacterial cells
3. Munich lab demonstrates diesel truck engine with barely measurable emissions
4. Scientists demonstrate link between genetic defect and brain changes in schizophrenia
5. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
6. Case Western Reserve University researcher demonstrates that messenger RNA are lost in translation
7. Scientists demonstrate importance of niche differences in biodiversity
8. University of Leicester geologists demonstrate extent of ancient ice age
9. Demonstration Features Commercial Technology for Combating Terrorism
10. Demonstration Features Commercial Technology for Combating Terrorism
11. Combating Terrorism with Commercial Technology: 2009 Force Protection Equipment Demonstration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the demons of dementia possess and damage brain cells
(Date:8/19/2014)... (Boston) Some infants born with neonatal abstinence ... a more difficult time going through withdrawal than ... understood. While genetic and epigenetic (when genes are ... identified as potential factors, researchers at Boston University ... (BMC) conducted a first of its kind study ...
(Date:8/19/2014)... at San Antonio and The University of Texas at ... than $750,000 in grants through the San Antonio Life ... SALSI is a model of how a general academic ... forces for greater research and graduate education. , The ... public health issues and diseases of global impact. Funding ...
(Date:8/19/2014)... 19, 2014A new ovoid structure discovered in the Nakhla ... a variety of minerals, and shows evidence of undergoing ... of the permafrost and mixing of surface and subsurface ... of analytical studies to determine the origin of this ... this ovoid formed, point to the most likely conclusion, ...
Breaking Biology News(10 mins):In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3Life on Mars? Implications of a newly discovered mineral-rich structure 2
... Jerusalem, May 23, 2011 -- Research teams at ... Jerusalem have won a prestigious $300,000 award from the ... devoted to transformative science, The BSF defines transformative science ... radically change our understanding of an important scientific concept, ...
... May 22, 2011 -- Combining the cutting-edge technology of ... public health officials can get a more detailed picture ... stop them, say researchers today at the 111th General ... health agencies are now able to harness the power ...
... separate genetic lineages that were isolated from each other by ... U.S. Forest Service Pacific Northwest Research Station study. The ... a monthly publication of the stationcan assist efforts aimed ... "When most people think of the red fox, they ...
Cached Biology News:Research teams at Hebrew University, University of Kentucky win Israel-US science award 2Genomics and social network analysis team up to solve disease outbreaks 2Genetic study clarifies evolutionary origin of elusive montane red fox 2
(Date:8/20/2014)... could improve the health of your heart, researchers have ... used a standard TENS machine like those designed to ... tragus, the small raised flap at the front of ... , The stimulation changed the influence of the nervous ... that can drive failing hearts too hard. , Professor ...
(Date:8/19/2014)... 2014 One of the major ... an inadequate vascular supply. Nutrient and gas transport ... is critical for successful regeneration and integration into ... deficiencies in vascularization and promote angiogenesis in a ... scaffold design and architecture, and enhancing scaffolds with ...
(Date:8/19/2014)... 2014 A Geisinger researcher on a personal ... Centers for Disease Control and Prevention (CDC) award recognizing ... concern. Joseph Boscarino , Ph.D. MPH, ... team of researchers nominated for the Centers for Disease ... for Data Methods and Study Design. "Hepatitis ...
(Date:8/19/2014)... La Jolla, CA (PRWEB) August 19, 2014 ... the toll Parkinson’s disease can take on an individual. ... tremoring extremities, decreased facial expression, problems swallowing and severe ... due to the dying off of dopamine producing neurons ... retain themselves from a disease that slowly and progressively ...
Breaking Biology Technology:'Tickling' your ear could be good for your heart 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3
... , Key words: ... • LEADseeker • DeepBlueC• cell-based assays , ... pressure is forcing organizations to continually increase screening throughput. Yet accuracy ... luminescence cell-based assays. LEADseeker™ Multimodality Imaging System was developed to meet ...
... , The cell ... On the one hand this fundamental process provides the opportunity to ... hand drugs and targets in other therapeutic areas must be tested ... Fluorescence Kit is a precise, fast, and simple fluorescence assay to ...
... , , J. Samskog, H. ... GE Healthcare, Uppsala, Sweden , ... method was developed to analyse phosphopeptides in mouse brain tissue. The ... by reversed-phase chromatography (RPC) using Ettan MDLC. The detection was performed ...
Cached Biology Technology:Use of BRET2 luminescence cell-based assays with LEADseeker Multimodality Imaging System 2Use of BRET2 luminescence cell-based assays with LEADseeker Multimodality Imaging System 3Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 2Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 3Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 4Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000 5Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4
... in your 35mm dish without transferring ... Chamber has separate openings for solution ... fluctuations of the liquid level in ... from entering the chamber. An adjustable ...
... (BTI-TN-5B1-4) derived from Trichoplusia ni egg ... be capable of expressing significantly higher ... to other insect cells. High Five ... time as adherent cultures- Quick adaptation into ...
... The steadylite plus assay ... High assay sensitivity, Designed for ... Suitable for higher density microplates ... plates, Odor free, Convenient storage ...
... universal lysis buffer, PCR mix, DNA polymerase ... l volume PCR reactions. This system can ... positive rod and coccus bacteria, such as ... Aureus, Streptococcus Agalactiae, and etc. With the ...
Biology Products: