Navigation Links
How the demons of dementia possess and damage brain cells
Date:3/3/2010

A study from EPFL's (Ecole Polytechnique Fdrale de Lausanne) Laboratory of Neuroenergetics and Cellular Dynamics in Lausanne Switzerland, published today in the Journal of Neuroscience, may lead to new forms of treatment following a better understanding of how Amyloid-Beta found in cerebral plaques, typically present in the brain of Alzheimer's patients, may lead to neurodegeneration. Researchers in Lausanne have studied how the functions of certain cells called astrocyteswhich normally protect, repair, and transfer energy to neuronsare impaired when "possessed" by aggregated Amyloid-Beta.

Alzheimer's disease currently affects more than 26 million people worldwide and estimates of up to four times as many sufferers by 2050 has made studying its causes a top priority for neuroscientists.

While the exact mechanisms by which the formation of plaques occurs and how they cause neurodegeneration and dementia is still a matter of debate in the scientific world, this study sheds a new light on how astrocytes may participate in the development of Alzheimer's disease. This new understanding of the interaction between Amyloid-Beta and astrocytes could lead to more effective therapies for Alzheimer's disease by trying to rescue astrocytic functions by deactivating the scavenger receptors.

The current study explores the causal relationship between the build-up of the Amyloid-Beta protein, associated with the formation of plaques, and the impairment of astrocyte's functions. Pierre Magistretti, director of the Brain Mind Institute and the Center for Psychiatric Neurosciences at CHUV/UNIL, and Igor Allaman, post doctoral fellow in Magistretti's lab, have succeeded in determining how built-up Amyloid-Beta infiltrates the astrocyte cells and alters their proper functioning, thus leading to the death of surrounding neurons. "To penetrate the astrocyte, the pathological protein goes through a 'scavenger' receptor." explains Igor Allaman. "Our
'/>"/>

Contact: Michael Mitchell
michael.mitchell@epfl.ch
41-798-103-107
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing
2. Researchers demonstrate nanoscale X-ray imaging of bacterial cells
3. Munich lab demonstrates diesel truck engine with barely measurable emissions
4. Scientists demonstrate link between genetic defect and brain changes in schizophrenia
5. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
6. Case Western Reserve University researcher demonstrates that messenger RNA are lost in translation
7. Scientists demonstrate importance of niche differences in biodiversity
8. University of Leicester geologists demonstrate extent of ancient ice age
9. Demonstration Features Commercial Technology for Combating Terrorism
10. Demonstration Features Commercial Technology for Combating Terrorism
11. Combating Terrorism with Commercial Technology: 2009 Force Protection Equipment Demonstration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the demons of dementia possess and damage brain cells
(Date:6/30/2015)... To bolster its efforts and commitment to fighting cyber fraud, ... of two new team members. Dimitri ... Raviv will act as head of strategic alliances. These ... the most secure solutions for the enterprise market. ... a provider of security and management products, which was acquired ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... company as CEO to help further develop Genisphere,s therapeutics ... of partnering experience, having spent much of the last ... Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. Tom ... on Technology and Biotech Corporate Finance. He graduated from ...
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ... America Biomedical Sensors Market - Growth, Trends & Forecasts ... Latin America Biomedical Sensors market is estimated at $0.65 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Latin America Biomedical Sensors Market Report 2015-2020 2
... of Minnesota researcher has found a universal rule that regulates ... that may also offer a key to calculating their carbon ... order to construct valid models of global carbon dioxide cycling. ... and animals through the process of respiration; Peter Reich, a ...
... A recent study shows that hundreds of genes contribute ... time these genes, many of which are potential contributors ... study. , The group led by Professor Jussi Taipale ... Finland) has identified genes contributing to cell growth and ...
... against the bird flu virus H5N1, derived from horses, ... virus. , A study published today in the ... that a dose of 100 µg of horse anti-serum ... antibodies developed in horses could potentially be used to ...
Cached Biology News:Of mice, men, trees and the global carbon cycle 2Of mice, men, trees and the global carbon cycle 3Genes involved in cell growth and cell division identified 2
(Date:7/1/2015)... Bermuda , July 1, 2015  Axovant ... company focused on the treatment of dementia, today ... briefing on July 22 at 5:45 p.m. EDT ... the Alzheimer,s Association International Conference 2015 (AAIC). ... remarks: , Dr. Lawrence Friedhoff ...
(Date:7/1/2015)... ... 01, 2015 , ... A newly launched business plan contest will ask startup ... innovation in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see ... a period of expert mentorship from a senior industry figure drawn from the Pistoia ...
(Date:7/1/2015)... ... 01, 2015 , ... Apex Therapeutics announced today that company CEO, David Broecker ... , The presentation took place on Tuesday, June 16 and provided an update ... APX3330 for the treatment of pancreatic cancer. A copy of the company overview ...
(Date:7/1/2015)... 2015  UCB, a multinational biopharmaceutical company, and ... in designing, transforming, and running intelligent business operations, ... of their close collaboration in driving transformation that ... services (GBS) finance organization. The Aecus ... work together effectively to embrace the innovative promise ...
Breaking Biology Technology:Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... - In a criminal trial, as any fan of TV ... defense goes second. The accused can appear in deep trouble, at ... often carries the day. , ,Not only does that make for ... works in real life. Those who file the charges speak first, ...
... - Midwest Fiber Networks , which has promised Milwaukee ... 2008, has been granted a reprieve by the Milwaukee ... ,The council has voted to give Midwest Fiber until June ... of the citywide wireless network. The company was to have ...
... that the recent U.S. Patent and Trademark Office ... arm of the University of Wisconsin could be ... cell research. , ,As one of the parties who lodged ... embryonic stem cells held by the Wisconsin Alumni Research ...
Cached Biology Technology:Here's why Wisconsin's stem cell patents are being challenged 2Here's why Wisconsin's stem cell patents are being challenged 3Here's why Wisconsin's stem cell patents are being challenged 4Patent ruling doesn't tarnish Wisconsin's stem cell leadership 2Patent ruling doesn't tarnish Wisconsin's stem cell leadership 3
Dog polyclonal to Porcine Pancreatic Islets of Langerhans Cells ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Pig): Sonicated crude membrane fraction of porcine p...
Anti-Cohesin (Scc1/Rad21) Monoclonal Antibody Research Focus: signal transduction Storage: -20C Shipping Temperature: +4C...
Proline-serine-threonine phosphatase-interacting protein 2...
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Biology Products: