Navigation Links
How the demons of dementia possess and damage brain cells
Date:3/3/2010

A study from EPFL's (Ecole Polytechnique Fdrale de Lausanne) Laboratory of Neuroenergetics and Cellular Dynamics in Lausanne Switzerland, published today in the Journal of Neuroscience, may lead to new forms of treatment following a better understanding of how Amyloid-Beta found in cerebral plaques, typically present in the brain of Alzheimer's patients, may lead to neurodegeneration. Researchers in Lausanne have studied how the functions of certain cells called astrocyteswhich normally protect, repair, and transfer energy to neuronsare impaired when "possessed" by aggregated Amyloid-Beta.

Alzheimer's disease currently affects more than 26 million people worldwide and estimates of up to four times as many sufferers by 2050 has made studying its causes a top priority for neuroscientists.

While the exact mechanisms by which the formation of plaques occurs and how they cause neurodegeneration and dementia is still a matter of debate in the scientific world, this study sheds a new light on how astrocytes may participate in the development of Alzheimer's disease. This new understanding of the interaction between Amyloid-Beta and astrocytes could lead to more effective therapies for Alzheimer's disease by trying to rescue astrocytic functions by deactivating the scavenger receptors.

The current study explores the causal relationship between the build-up of the Amyloid-Beta protein, associated with the formation of plaques, and the impairment of astrocyte's functions. Pierre Magistretti, director of the Brain Mind Institute and the Center for Psychiatric Neurosciences at CHUV/UNIL, and Igor Allaman, post doctoral fellow in Magistretti's lab, have succeeded in determining how built-up Amyloid-Beta infiltrates the astrocyte cells and alters their proper functioning, thus leading to the death of surrounding neurons. "To penetrate the astrocyte, the pathological protein goes through a 'scavenger' receptor." explains Igor Allaman. "Our study has shown that if we impair Amyloid-Beta build-up, or activation of this receptor, astrocytes continue to fulfill their normal neuroprotective functions even in the presence of the Amyloid-Beta."


'/>"/>

Contact: Michael Mitchell
michael.mitchell@epfl.ch
41-798-103-107
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Related biology news :

1. Aware, Inc. Joins HIMSS10 Interoperability Showcase to Demonstrate Standards-Based Medical Image Sharing
2. Researchers demonstrate nanoscale X-ray imaging of bacterial cells
3. Munich lab demonstrates diesel truck engine with barely measurable emissions
4. Scientists demonstrate link between genetic defect and brain changes in schizophrenia
5. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
6. Case Western Reserve University researcher demonstrates that messenger RNA are lost in translation
7. Scientists demonstrate importance of niche differences in biodiversity
8. University of Leicester geologists demonstrate extent of ancient ice age
9. Demonstration Features Commercial Technology for Combating Terrorism
10. Demonstration Features Commercial Technology for Combating Terrorism
11. Combating Terrorism with Commercial Technology: 2009 Force Protection Equipment Demonstration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the demons of dementia possess and damage brain cells
(Date:1/11/2016)... Synaptics Incorporated (NASDAQ: SYNA ), the ... its ClearPad ® TouchView ™ 4300 touch ... categories in the 8 th Annual Mobile Excellence ... The Synaptics ® TDDI solution enables faster time-to-market, ... devices, brighter displays and borderless designs. ...
(Date:1/8/2016)... Connecticut , January 8, 2016 ... m-commerce market and WorldVentures ® , a privately held ... and an Inc. 5000 fastest-growing company announced ... strategic investment of $2 million in Nxt-ID to develop ... based on Nxt-ID,s Wocket ® , a unique smart ...
(Date:1/7/2016)... 2016  A United States District Court in ... the country to interpret a biometric privacy statute in ... against the photo website Shutterfly brought by the law firm ... vs. SHUTTERFLY, INC.; and THISLIFE, INC ( N.D. ... violates the Illinois Biometric Privacy Act by collecting and ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, ... various medical institutions attended a ceremony in late 2015 ... personalized cell therapy in 2016. --> ... Clinical Translation Platform for Personalized Cell Therapy" was hosted ... Cell Production Center, both subsidiaries of Beike Biotechnology Co., ...
(Date:2/4/2016)... , February 4, 2016 ... a biotechnology acceleration company is pleased to provide the following ... --> Over the last 3 months we have ... securities purchase agreements exceeding $1,000,000. As a result, we have ... Mannin Research Inc. license agreement and expect that development to ...
(Date:2/4/2016)... Feb. 4, 2016 Sinovac Biotech Ltd. ("Sinovac" ... provider of biopharmaceutical products in China ... board of directors received on February 4, 2016 a ... a consortium comprised of PKU V-Ming ( Shanghai ... Ltd., CICC Qianhai Development ( Shenzhen ) ...
(Date:2/4/2016)... ... February 04, 2016 , ... Many of the engineers at FireflySci, Inc. have ... sets them apart from other cuvette manufacturers is their supercharged customer service and their ... top of this steady flow of inside information, they have recently revamped their manufacturing ...
Breaking Biology Technology: