Navigation Links
How the common 'cat parasite' gets into the brain
Date:12/7/2012

the cat, which through its faces can infect the food that other rats might then proceed to eat. A number of studies also confirm that mental diseases like schizophrenia, depression and anxiety syndrome are more common in people with toxoplasmosis, while others suggest that toxoplasmosis can influence how extroverted, aggressive or risk-inclined an individual's behaviour is.

"We've not looked at behavioural changes in people infected with toxoplasma, as that's been dealt with by previous studies," says Dr Barragan. "Instead, we've shown for the first time how the parasite behaves in the body of its host, by which I mean how it enters the brain and manipulates the host by taking over one of the brain's neurotransmitters."

In one laboratory experiment, human dendritic cells were infected with toxoplasma. After infection, the cells, which are a key component of the immune defence, started secreting the signal substance GABA. In another experiment on live mice, the team was able to trace the movement of infected dendritic cells in the body after introducing the parasite into the brain, from where it spread and continued to affect the GABA system.

GABA is a signal substance that, amongst other effects, inhibits the sensation of fear and anxiety. Disturbances of the GABA system are seen in people with depression, schizophrenia, bipolar diseases, anxiety syndrome and other mental diseases.

"For toxoplasma to make cells in the immune defence secrete GABA was as surprising as it was unexpected, and is very clever of the parasite," says Dr Barragan. "It would now be worth studying the links that exist between toxoplasmosis, the GABA systems and major public health threats."


'/>"/>
Contact: The Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Why some strains of Lyme disease bacteria are common and others are not
2. Second most common infection in the US proving harder to treat with current antibiotics
3. Researchers discover 2 genetic flaws behind common form of inherited muscular dystrophy
4. Western aspen trees commonly carry extra set of chromosomes
5. Common food preservative may slow, even stop tumor growth
6. Study reveals how common gene mutation affects kids with autism spectrum disorders
7. Novel non-antibiotic agents against MRSA and common strep infections
8. Rare genetic disease offers insight into common cancers
9. A new light shed on genetic regulations role in the predisposition to common diseases
10. Common antifungal drug decreases tumor growth and shows promise as cancer therapy
11. Common parasite may trigger suicide attempts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... to pay a premium for fruits, vegetables and other ... label claims is another matter. Now scientists studying conventional ... make sure farms are labelling their produce appropriately. Their ... and Food Chemistry , could help prevent organic food ... Safety Authority and the Wuerzburg University note that the ...
(Date:8/27/2014)... advocates, campaigns against trans-fats have largely succeeded in ... aim at sugar for its potential contributions to ... still wrangling over the best way to assuage ... article in Chemical & Engineering News ... Chemical Society. , In the article, Stephen Ritter, ...
(Date:8/27/2014)... seven hours ago the Happy Camp Complex of fires ... the July complex had consumed 35,530 as of eight ... on the Happy Camp Ranger District of the Klamath ... on August 11, 2014. All but three of those ... a list of contained fires and their size at ...
Breaking Biology News(10 mins):Happy Camp and July Fire Complexes in California 2
... Registration is now open for Disease Models & ... Mechanisms. This one-day Symposium will ... and disease processes at the cellular and whole-organism ... be used to address this issue. It is ...
... flower, created by the union of two foreign plant species, ... Genetic changes in this attractive yellow-flowered hybrid have allowed it to ... new species that has originated in the wild in the last ... to have originated in this way, yet only a handful of ...
... A San Francisco State University biologist has released the ... bee populations and has found low numbers of bees in ... habitat loss is one of the primary reasons for sharp ... Now the researcher plans to add to her data ...
Cached Biology News:Rare glimpse into the origin of species 2SF State researcher releases first results from nationwide bee count 2SF State researcher releases first results from nationwide bee count 3
(Date:8/27/2014)... -- Research and Markets  has announced the addition ... Industry Report 2014" report to their offering. ... Industry Report 2014 is a professional and in-depth study ... mass spectrometer industry. The report provides a ... and industry chain structure. The isotope ratio mass spectrometer ...
(Date:8/27/2014)... 27, 2014 Riviera Beach, Florida ... the creation of the Sancilio Scientific Advisory Board ... SCI’s philosophy of looking to nature for pharmaceutical ... actions are based on sound scientific data, analyses, ... Board provides a vehicle for SCI to receive ...
(Date:8/27/2014)... City, OR (PRWEB) August 27, 2014 ... Report, “Consolidation continues to reshape the look and feel ... nutrition. Consumer demand for higher-quality ingredients will push for ... North American market have experienced strong market growth in ... ethical attributes in their food and cosmetics to fit ...
(Date:8/27/2014)... 27, 2014 Budding Biomedical Scientists ... University School participated in the Scientific Enrichment ... University’s School of Medicine . , ... unparalleled professional experience in the sciences and brings ... faculty and students for both academic and career ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2
... 7, 2011 Vaxart, Inc., a San Francisco biotechnology company ... I clinical trial. This is the first clinical study evaluating ... The trial site is in the United States. ... is demonstrated with one vaccine, we can expect that later ...
... DuPont (NYSE: DD ) Chair and ... JPMorgan Diversified Industries Conference to expect attractive long-term growth ... in attractive areas, broad-based growth, especially in developing markets, ... DuPont,s 2011 earnings per share (EPS) outlook in the ...
... Systems International (OTCBB: IFRS) is pleased to announce that its ... NatuRx™ HIV/AIDS treatment and will push forward with clinical trials ... pilot study with two HIV/AIDS patients this week which also ... AIDS victims on June 5th, 1981. "The results ...
Cached Biology Technology:Vaxart Begins First Oral Vaccine Clinical Trial 2DuPont Chair & CEO: Delivering Innovative Solutions and Long-term Growth 2DuPont Chair & CEO: Delivering Innovative Solutions and Long-term Growth 3Infrared Systems International's Subsidiary, AquaLiv, Inc., Strives to Be a Game Changer in Fight Against HIV/AIDS 2Infrared Systems International's Subsidiary, AquaLiv, Inc., Strives to Be a Game Changer in Fight Against HIV/AIDS 3
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
ID clarifier: With ethidium bromide (50 μg/ml)...
... in DMEM and harvested at the log phase ... antigens in their native forms, cells were fixed ... a 12-well (5 mm) adhesive coated slide, with ... attachment and to minimize background staining. Each ...
Biology Products: