Navigation Links
How the cells remove copper
Date:12/20/2013

We are fundamentally dependent on the presence of copper in the cells of the body. Copper is actually part of the body's energy conversion and protective mechanisms against oxygen radicals, as well as part of the immune system, and it also has great importance for the formation of e.g. hormones and neurotransmitters.

Imbalance in the body's copper level has therefore a number of serious consequences for our health, as can be seen with the disorder Wilson's disease, where the liver accumulates copper in harmful quantities, and the very serious Menkes syndrome, where a congenital defect in the cell's copper charge of key enzymes causes e.g. neurological defects, muscular disorders, low blood pressure and osteoporosis, and is typically fatal within the first three years of life.

Both Menkes syndrome and Wilson's disease are caused by defects in the mechanism that regulates the copper levels in the cells.

A mechanism which researchers at the Danish National Research Centre PUMPkin at Aarhus University have now moved a step closer to understand.

They have shown that the protein that is responsible for the excretion of copper in the cells of the body makes use of a unique transport mechanism.

The results have recently been published in the recognised scientific journal Nature Structural and Molecular Biology.

"The copper pump is a protein that has the function of removing the toxic surplus of copper from the cells. The protein is located partially inside the cell, and partially in the surrounding cell membrane. The parts of the protein which are located inside the cell function almost as a series of cogs, which interlace with one another. Putting it simply, when the cogs rotate they draw on the part of the protein located in the cell membrane, and in this manner a tiny passage opens and closes through the membrane. The copper is pumped out through the passage," says PhD student Oleg Sitsel, co-author of the
'/>"/>

Contact: Poul Nissen
pn@mb.au.dk
45-28-99-22-95
Aarhus University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the cells remove copper
(Date:8/12/2015)... NEW YORK , Aug. 12, 2015 /PRNewswire/ ... how hackers can attack Android phones to steal ... identifies the increasing availability of fingerprint scanners on ... of utmost concern. To secure biometrics on mobile ... platform to augment these convenient authentication systems with ...
(Date:8/11/2015)... Sweden , August 11, 2015 Today, ... FPC1155. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a prominent smartphone manufacturer in ... ZUK selected FPC1 155 for ...
(Date:8/10/2015)... 2015 The latest 364 page report ... of the global border security market . Visiongain ... in 2015. Now: Border security is hard to ... the business critical issue you need to know about - ... objective analysis of how this will impact your company and ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9
... the University of Florida's McKnight Brain Institute have created ... time duplicates neurogenesis -- the process of generating new ... today's (June 13) Proceedings of the National Academy of ... the promise of producing a limitless supply of a ...
... Iron key to nitric oxide reductionResearchers at the Georgia ... the United Kingdom have uncovered a mechanism with which ... The findings, which could ultimately lead to the development ... 2005 issue of the journal Nature. , "Nitric oxide ...
... Infectious Diseases (NIAID), part of the National Institutes of ... cause such serious diseases as West Nile fever, yellow ... in different ways depending on whether they are transmitted ... new approaches to developing vaccines and treatments against these ...
Cached Biology News:For first time, brain cells generated in a dish 2For first time, brain cells generated in a dish 3Researchers uncover E. coli's defense mechanism 2Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses 2Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses 3
(Date:9/3/2015)... , Sept. 3, 2015 /PRNewswire/ - bioLytical Laboratories Inc., ... announce its study " Sensitivity of a rapid point ... enhanced by its affinity for HIV gp41 IgM antibodies ... Virology.  This study highlights INSTI,s ability to detect early ... findings at the 8 th annual International AIDS ...
(Date:9/3/2015)... ... September 03, 2015 , ... Park Systems announced that they ... 2015 at 9am PST. The webinar will focus on the methods and materials for ... printing, additive manufacturing is a broad term that encompasses “addition or fusion” of materials ...
(Date:9/2/2015)... Sept. 2, 2015 Axovant Sciences Ltd. (NYSE:  AXON), ... dementia, today announced upcoming presentations at three investor conferences: ... Baird 2015 Healthcare Conference in New York ... September 10 at 2:00 PM at the BioCentury NewsMakers Conference ... Broadway Hotel & Conference Center , Thursday, September 17 ...
(Date:9/2/2015)... , Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s new ... Companies" to their offering. This ... development of sequencing technologies, and their applications. Current ... as companies developing them. Various applications of sequencing ...
Breaking Biology Technology:bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 2bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 2Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 4Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2
... Debiopharm Group,(Debiopharm), a global independent biopharmaceutical development ... presented the ,Debiopharm,Life Sciences Award, to Hungarian ... in both fundamental and clinical neuroscience. Funded,by ... Federale de Lausanne,(EPFL), the ceremony took place ...
... BETHESDA, Md., Aug. 29 Sucampo,Pharmaceuticals, Inc. (Nasdaq: ... public offering have exercised in full their option to,purchase ... cover,over-allotments and that the closing of that purchase took ... at today,s closing were sold by a selling,stockholder and ...
... Webb Promoted to Newly Created Role of Senior Vice President of ... Regulatory, and Clinical Affairs, Philip R. Licari to Step Down as Chief ... ... Medical,Inc. (Nasdaq: NXTM ), the manufacturer of the NxStage System One (TM),portable ...
Cached Biology Technology:The Debiopharm Life Sciences Award Goes to Dr Nusser for his Outstanding Research in Neuroscience 2Sucampo Pharmaceuticals Announces Exercise and Closing of IPO Over-Allotment Option 2NxStage Medical Provides Update on Medisystems Acquisition 2NxStage Medical Provides Update on Medisystems Acquisition 3NxStage Medical Provides Update on Medisystems Acquisition 4NxStage Medical Provides Update on Medisystems Acquisition 5
... is the standard water based mounting medium ... the permanent preservation of peroxidase and alkaline ... to use and exhibits excellent optical characteristics. ... mounting medium that permits the long-term storage ...
... monoclonal antibody development to targets including proteins ... DNA, and cancer-specific surface antigens. A&Gs ... is completed in approximately 40 days (duration ... of antigens). Phase I: Immunization, test ...
PCR System for increased fidelity, yield and length of PCR products. Amplifies targets up to 10 kb from human genomic DNA....
...
Biology Products: