Navigation Links
How the cell swallows
Date:8/3/2012

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have combined the power of two kinds of microscope to produce a 3-dimensional movie of how cells 'swallow' nutrients and other molecules by engulfing them. The study, published today in Cell, is the first to follow changes in the shape of the cell's membrane and track proteins thought to influence those changes. It also provides ample data to investigate this essential process further.

This 'swallowing', called endocytosis, is involved in a variety of crucial tasks. It is used by brain cells relaying information to each other, for instance, and is also hijacked by many viruses, which use it to invade their host's cells. When a cell is about to swallow some molecules, a dent appears in the cell's membrane, and gradually expands inwards, pinching off to form a little pouch, or vesicle, that transports molecules into the cell.

To investigate how the cell's machinery pulls in the membrane and forms the vesicle, researchers led by Marko Kaksonen and John Briggs employed a method they developed two years ago to faithfully follow the exact same molecules first under a light microscope and then with the higher resolution of an electron microscope. This enabled them to combine two sets of data that so far could only be obtained in isolation: the timing and sequence with which different components of the cell's machinery arrive at the vesicle-to-be, and the 3D changes to membrane shape that ultimately form that vesicle. They discovered, for instance, that the first proteins to arrive on the inside of the cell's membrane are not able to start bending it inwards until a network of the cell's scaffolding protein, actin, forms and starts pulling on the membrane.

The data used to make the video is freely available to the scientific community and will, Kaksonen and Briggs believe, provide valuable information to others trying to develop physical models of how this process works. The EMBL scientists themselves are probing the roles of individual proteins in this process, by perturbing them, and would like to extend the current work in yeast to human cells.


'/>"/>
Contact: Lena Raditsch
lena.raditsch@embl.de
49-622-138-78125
European Molecular Biology Laboratory
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... Jacksonville, FL (PRWEB) , ... July 26, 2017 ... ... deep learning algorithms targeted towards leveraging the years of diagnostic excellence by Mayo ... Logix. The first product suite will be distributed through the Microsoft Azure ...
(Date:7/25/2017)... Chestertown, Maryland (PRWEB) , ... ... ... is pleased to welcome Chuck Heinz as Executive Director of Strategic ... asset to the Benchworks team. , Chuck’s professional experience encompasses marketing and ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... stock market news outlet had initiated coverage on Interpace Diagnostics. Interpace Diagnostics ... identifies exposure, progression and risk analysis from specific cancers in humans. , ...
(Date:7/20/2017)... ... ... VIC Technology Venture Development™ (VIC™), is pleased to announce that James ... to strengthen and diversify VIC’s board. , "We are excited to have Jamie join ... business executive with a broad range of experience directly relevant to VIC as we ...
Breaking Biology Technology: