Navigation Links
How the brain cell works: A dive into its inner network
Date:12/21/2011

CORAL GABLES, FL (December 20, 2011) University of Miami biology professor Akira Chiba is leading a multidisciplinary team to develop the first systematic survey of protein interactions within brain cells. The team is aiming to reconstruct genome-wide in situ protein-protein interaction networks (isPIN) within the neurons of a multicellular organism. Preliminary data were presented at the American Society for Cell Biology annual meeting, December 3 through 7, 2011, in Denver, Colorado.

"This work brings us closer to understanding the mechanics of molecules that keep us functioning," says Chiba, principal investigator of this project. "Knowing how our cells work will improve medicine. Most importantly, we will gain a better understanding of what life is at the molecular level."

Neurons are the cells that are mainly responsible for signaling in the brain. Like all other cells, each neuron produces millions of individual proteins that associate with one another and form a complex communication network. Until recently, observing these protein-protein interactions had not been possible due to technical difficulties. Individual proteins are small and typically less than 10 nm (nanometer) in diameter. Yet, this nano-scale distance was considered to be off-limits even with super-resolution microscopy.

Now, Chiba and his collaborators have developed a novel methodology to examine interaction of individual proteins in the fruit fly the model organism of choice for this project. The researchers are creating genetically engineered insects that are capable of expressing over 500 fluorescently-tagged assorted proteins, two at a time. The fluorescent tags make it possible to visualize the exact spot where a given pair of proteins associates with each other.

The team utilizes a custom- built 3D FLIM (fluorescent lifetime imaging microscopy) system to quantify this association event within the cells of a live animal. FLIM shows the location and time o
'/>"/>

Contact: Catharine Skipp
c.skipp@miami.edu
305-284-3667
University of Miami
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity
2. When standard treatment fails: Jefferson to start unique immunotherapy for brain tumor patients
3. Bikers warning! EPO hits blood vessels to raise blood pressure in the brain
4. Swarms of bees could unlock secrets to human brains
5. Decision making in bee swarms mimic neurons in human brains
6. Barrow physicians chronicle Vladimir Betz in Brain
7. Maternal care influences brain chemistry into adulthood
8. Max Planck Florida Institute scientists create first realistic 3D reconstruction of a brain circuit
9. New insights into how the brain reconstructs the third dimension
10. Scientists discover how brain corrects bumps to body
11. University Hospitals Seidman Cancer Center tests novel drug that makes brain tumors glow hot pink
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the brain cell works: A dive into its inner network
(Date:5/21/2015)... 2015 The Sync Project™ , a ... health, today announced a collaborative partnership with Berklee,s ... center on collaboration on original research, joint course development ... the collaboration, The Sync Project and BerkleeICE are exploring ... in the 2015-2016 academic year.  The ...
(Date:5/19/2015)... 2015 Fingerprint Cards (FPC) has received ... FPC1155 and FPC1035 from one if its module partners. Deliveries ... Q3 2015 and the sensors will be used by smartphone ... for 2015 hereby amount to 740 MSEK to date. In ... MSEK and a number of smaller orders not separately communicated ...
(Date:5/18/2015)... 2015 Fingerprint Cards (FPC) has received ... FPC1155 and FPC1035 from one if its module partners. Deliveries ... Q3 2015 and the sensors will be used by smartphone ... for 2015 hereby amount to 740 MSEK to date. In ... MSEK and a number of smaller orders not separately communicated ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... encourages exercise, improves psychological health these may sound like ... actually among the benefits of owning a four-legged, furry ... Veterinary Medicine Research Center for Human-Animal Interaction (ReCHAI) will ... ages during the International Society for Anthrozoology and Human-Animal ...
... N.C. -- Spotted hyenas may not be smarter than ... the primates on cooperative problem-solving tests. Captive pairs ... two ropes in unison to earn a food reward ... training. Experienced hyenas even helped inexperienced partners do the ...
... valve disease includes either repairing the patient,s diseased valve ... an animal tissue valve. The majority of those procedures ... the chest. Now, after a six-year study, surgeons at ... that minimally invasive mitral valve repair techniques, through only ...
Cached Biology News:A pet in your life keeps the doctor away 2A pet in your life keeps the doctor away 3Hyenas cooperate, problem-solve better than primates 2Hyenas cooperate, problem-solve better than primates 3Study details safe, effective, minimally invasive mitral valve repair 2Study details safe, effective, minimally invasive mitral valve repair 3
(Date:5/20/2015)... and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ) has announced ... Outlook 2020 " report to their offering. ... medicine is expected to have huge marketing potential. Presently, ... the growth of deregulated organs. Several therapeutic molecules are ... form new tissue or sometimes organ transplant is required. ...
(Date:5/20/2015)... 20, 2015  Health eCareers, the healthcare industry,s ... with job seekers looking for the flexibility of ... mobile and online tool dedicated exclusively to temporary ... SHIFT enables employers to quickly find and ... per diem and other temporary positions, eliminating the ...
(Date:5/20/2015)... -- Haemonetics Corporation (NYSE: HAE ) announced today that ... at The Jefferies 2015 Global Healthcare Conference in ... , 2015 at 8:30am Eastern time.  ... webcast at: http://wsw.com/webcast/jeff88/hae ... a global healthcare company dedicated to providing innovative blood ...
(Date:5/20/2015)... , May 19, 2015 Research and Markets ... addition of the "Bone Morphogenetic Proteins Market ... Trauma, Reconstructive and Oral - Maxillofacial) - Global ... 2014 - 2022" report to their offering. ... is studied based on the types of recombinant ...
Breaking Biology Technology:Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3Global Bone Morphogenetic Proteins Market Industry Analysis 2014 - 2022 2
... Biotech Product with ... Direct Consumer Benefits, DES MOINES, Iowa, ... oil trait from DuPont (NYSE: DD ),will deliver increased nutritional ... market. The high oleic soybean,oil trait is the next generation of ...
... Data presented at AAAAI 64th Annual Meeting also show ... effective treatment for HAE attacks across all body sites, ... a safe and effective therapy that rapidly relieves acute,abdominal ... a rare and serious genetic disorder, according to data,presented ...
... March 18 /PRNewswire/ - Aegera Therapeutics announced ... clinical trial for AEG33773, a,novel, orally bioavailable ... painful diabetic neuropathy. The Phase I study ... of AEG33773 using a randomized,double blind, placebo ...
Cached Biology Technology:Research Confirms Better Oil from New DuPont High Oleic Soybean Trait 2Research Confirms Better Oil from New DuPont High Oleic Soybean Trait 3C1-Esterase Inhibitor Concentrate Rapidly Relieves Abdominal and Facial Attacks in Patients with Hereditary Angioedema, According to Pivotal Study 2C1-Esterase Inhibitor Concentrate Rapidly Relieves Abdominal and Facial Attacks in Patients with Hereditary Angioedema, According to Pivotal Study 3C1-Esterase Inhibitor Concentrate Rapidly Relieves Abdominal and Facial Attacks in Patients with Hereditary Angioedema, According to Pivotal Study 4Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain 2
... Panomer 9 oligodeoxynucleotides are ... labeled at the 5' ... Alexa Fluor dyes and ... assessing microarray spot morphology, ...
EDTA, disodium salt, 1 kg. Ethylene diaminetetraacetic acid.Dihydrate. Assay: 99.0-101.0%, nuclease-free.Risks: 36, 37, 38 ; Safety Precautions: 22, 36, 37. Category: Nucleotides & Enzymes & Biochemi...
Mycoplasma tested...
Alkaline Phosphatase Stabilizer Solution, 1 L...
Biology Products: