Navigation Links
How the body's energy molecule transmits 3 types of taste to the brain
Date:3/6/2013

Philippe Marambaud, PhD, have severely impaired perceptions of sweet, bitter and umami compounds; whereas, their recognition of sour and salty tastes remains mostly normal. The CALHM1 deficiency affects taste perception without interfering with taste cell development or overall function.

Using the CALHM1 knockout mice, team members from Monell and Feinstein tested how their taste was affected. "The mice are very unusual," says Monell's Michael Tordoff, PhD. "Control mice, like humans, lick avidly for sucrose and other sweeteners, and avoid bitter compounds. However, the mice without CALHM1 treat sweeteners and bitter compounds as if they were water. They can't taste them at all."

From all lines of evidence, the team concluded that CALHM1 is an ATP-release channel required for sweet, bitter, and umami taste perception. In addition, they found that CALHM1 was also required for "nontraditional" Polycose, calcium, and aversive high-salt tastes, implying that the deficit displayed in the knockout animals might best be considered as a loss of all GPCR-mediated taste signals rather than simply sweet, bitter and umami taste.

Interestingly, CALHM1 was originally implicated in Alzheimer's disease, although the link is now less clear. In 2008, co-author Marambaud identified CALHM1 as a risk gene for Alzheimer's. They discovered that a CALHM1 genetic variant was more common among people with Alzheimer's and they went on to show that it leads to a partial loss of function. They also found that this novel ion channel is strongly expressed in the hippocampus, a brain region necessary for learning and memory. So far, there is no connection between taste perception and Alzheimer's risk, but Marambaud suspects that scientists will start testing this hypothesis.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Story tips From the Department of Energys Oak Ridge National Laboratory, March 2012
2. First complete full genetic map of promising energy crop
3. Polycrystalline diamond drill bits open up options for geothermal energy
4. NOAA science supports New Yorks offshore energy planning
5. Energy requirements make Antarctic fur seal pups vulnerable to climate change
6. Carnegies Greg Asner named Energy/Climate Fellow by US State Department
7. A new dimension for solar energy
8. Is bioenergy expansion harmful to wildlife?
9. University of Minnesota invention helps advance reliability of alternative energy
10. Nanocrystal-coated fibers might reduce wasted energy
11. Europe meets to discuss progress in energy research and development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the body's energy molecule transmits 3 types of taste to the brain
(Date:1/22/2015)... 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is ... the State of Washington,s Department of ... enrollment and central issuance system for driver,s licenses and identification ... project planning and development will start in January 2015, with ...
(Date:1/22/2015)... Hall E -   EyeLock Inc. , a market leader ... its EyeLock ID technology integrated in a 3D printed automobile ... Ridge National Laboratory (ORNL) at the 2015 North ... is being used to validate the driver and authorize the ...
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... a good thing better? A gene known as LIS1 is ... developing brain. When an LIS1 gene is missing, brains fail ... brain, are born severely mentally retarded. But new research by ... recently appeared in Nature Genetics, shows that having ...
... newly described fossil whales--a pregnant female and a male ... and provide new insights into how whales made the ... fossils, discovered in Pakistan in 2000 and 2004, are ... the online journal PLoS. "This stunning ...
... Albert Einstein College of Medicine of Yeshiva University have discovered ... causes disease. The study, published in the ... ( PNAS ), may help scientists develop new therapies or ... fungal infections occur most commonly in those with compromised immune ...
Cached Biology News:Weizmann Institute scientists show extra copies of a gene carry extra risk 2Early whales gave birth on land 2Scientists discover how deadly fungus protects itself 2
(Date:1/23/2015)... 23, 2015 Portal Solutions , a ... on Microsoft Office 365 and SharePoint platforms , today ... program for being one of the region’s fastest-growing mid-sized companies ... growth. , “To be recognized a second year in ...
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 21, 2015 Cambridge Semantics, the leading provider ... announced that 2014 was a record-breaking year across the board ... the Anzo Smart Data Platform and our Smart Data solutions, ... from diverse data which led to record growth for the ...
(Date:1/22/2015)... Boulder, CO / Rootstown, OH (PRWEB) January 22, 2015 ... sensitive detection platform, announced today that it has received AOAC-PTM ... O26, O45, O1O3, O111, O121, and O145; collectively referred to ... (E. coli) O157, at 1 colony forming unit (cfu) per ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... April 12, 2011 EMC Corporation (NYSE: ... today announced that EMC Isilon® customers City ... and the Translational Genomics Research Institute (TGen) are ... the Era of Big Data," at Bio-IT World Conference ...
... Careers, the leading online career service for life science ... Memberships. Previously, Bio Careers was available only to life ... Now, membership is open to individuals associated with top-ranked ... the Academic Ranking of World Universities.   ...
... Sanford Rose Associates - Charleston, a leading ... technology, has promoted Bonnie R. Siegel as Partner ... Health information technology continues to be the ... healthcare marketplace. Bonnie will continue to focus on ...
Cached Biology Technology:EMC Isilon Customers Discuss the Big Data Opportunity in Life Sciences at Bio-IT World Conference 2011 2Online Career Service for Postgraduate Life Scientists Expands Membership to Individuals 2Sanford Rose Associates - Charleston Promotes Bonnie Siegel to Partner 2
... Molecular Imaging Systems offer an optional ... science researchers to conveniently capture and ... organs and whole animals with molecular ... of molecular signals that are generated ...
...
... Features hardwall acrylic panels mounted ... to form a free-standing modular ... Class 10/ISO 3. Optional ceiling ... ionizers are configured to customer ...
... The first high-density serum biomarker chip ... serum proteins. An antibody chip containing 120 ... tool that enables biomarker discovery scientists to ... detection, benefits of therapy and the likelihood ...
Biology Products: