Navigation Links
How the body's energy molecule transmits 3 types of taste to the brain
Date:3/6/2013

PHILADELPHIA Saying that the sense of taste is complicated is an understatement, that it is little understood, even more so. Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now.

A team of investigators from nine institutions discovered how ATP the body's main fuel source is released as the neurotransmitter from sweet, bitter, and umami, or savory, taste bud cells. The CALHM1 channel protein, which spans a taste bud cell's outer membrane to allow ions and molecules in and out, releases ATP to make a neural taste connection. The other two taste types, sour and salt, use different mechanisms to send taste information to the brain.

Kevin Foskett, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania, and colleagues from the Monell Chemical Senses Center, the Feinstein Institute for Medical Research, and others, describe in Nature how ATP release is key to this sensory information path. They found that the calcium homeostasis modulator 1 (CALHM1) protein, recently identified by the Foskett lab as a novel ion channel, is indispensable for taste via release of ATP.

"This is an example of a bona fide ATP ion channel with a clear physiological function," says Foskett. "Now we can connect the molecular dots of sweet and other tastes to the brain."

Taste buds have specialized cells that express G-protein coupled receptors (GPCRs) that bind to taste molecules and initiate a complex chain of molecular events, the final step of which Foskett and collaborators show is the opening of a pore in the cell membrane formed by CALHM1. ATP molecules leave the cell through this pore to alert nearby neurons to continue the signal to the taste centers of the brain. CALHM1 is expressed specifically in sweet, bitter, and umami taste bud cells.

Mice in which CALHM1 proteins are absent, developed by Feinstein's
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Story tips From the Department of Energys Oak Ridge National Laboratory, March 2012
2. First complete full genetic map of promising energy crop
3. Polycrystalline diamond drill bits open up options for geothermal energy
4. NOAA science supports New Yorks offshore energy planning
5. Energy requirements make Antarctic fur seal pups vulnerable to climate change
6. Carnegies Greg Asner named Energy/Climate Fellow by US State Department
7. A new dimension for solar energy
8. Is bioenergy expansion harmful to wildlife?
9. University of Minnesota invention helps advance reliability of alternative energy
10. Nanocrystal-coated fibers might reduce wasted energy
11. Europe meets to discuss progress in energy research and development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the body's energy molecule transmits 3 types of taste to the brain
(Date:12/17/2014)... 2014 The Defense Logistics Agency is ... detect and prevent counterfeit microcircuits from entering into ... started performing an in-house microcircuit anti-counterfeit initiative dubbed ... of purchased microcircuits while increasing their reliability throughout ... will be conducted at DLA,s Electronics Product Test ...
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) ... Market in the APAC Region 2015-2019"  report to ... emerging in this market is advances in technology. ... to upgrade biometric solutions to the latest standard ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... one of the immune system,s key weapons against infection ... biliary atresia in infants, a disease where blocked bile ducts ... Cincinnati Children,s Hospital Medical Center also report that blocking a ... damage and may be a way to treat the most ...
... , , , ... Shopper Insights Conference, Perception Research Services International (PRS) and EmSense ... packaging research studies. The companies presented findings from a ... EmSense,s EmGear(TM) EEG unit to link package viewing patterns with ...
... The new research study led by scientists at ... that by improving overall ocean health, corals are better ... rising sea temperatures force corals to expel their symbiotic ... that is expected to increase in frequency as global ...
Cached Biology News:Scientists link immune system's natural killer cells to infant liver disease 2PRS And EmSense Partner To Integrate Bio-Sensory Measures In Packaging Research Studies 2Scripps-led study shows ocean health plays vital role in coral reef recovery 2
(Date:12/24/2014)... Md. , Dec. 24, 2014  United ... today that Medtronic, Inc. (NYSE: MDT ... the U.S. Food and Drug Administration (FDA) for ... implantable drug infusion system (including a newly developed ... (treprostinil) Injection delivered intravenously to patients with ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ... of the revenue and share analysis. , ...
(Date:12/24/2014)... On Friday, December 19, 2014, ... Omnibus and Continuing Resolution Appropriations Act of 2015, ... condition eligible to receive funding through the Congressionally ... Department of Defense (DoD). The Hydrocephalus Association (HA), ... Hill, is celebrating this victory for the over ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market ... a carefully analyzed data about the vital drivers, restraints, ... Full Copy of Report @ http://bit.ly/1yUxy0T , ... expansion will keep witnessing growth at an impressive CAGR ... driven by rapid technological advancements, government funding and investments, ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... The Netherlands , April 27, 2010 Immunovo,BV, a ... recent insights in oncology to develop novel,therapeutics, secures seed funding from Dutch ... , ... - Immunovo BV, a new,biotechnology company developing a novel technology platform ...
... Biotechnology Product Projects , , ... PARK, Md. , April 27 The Maryland Biotechnology Center, the ... and strengthen the state,s bioscience community, has enabled biotechnology product development projects to ... support. , , , ...
... Gage R&R of ... ... reports of quality failures in both the medical device and automotive industries, InterTech Development Company ... entire assembly and test systems, not just instruments. Having been called in to solve ...
Cached Biology Technology:Immunovo BV- A New Biotechnology Company is Announced 2Maryland Biotechnology Center Supports $270,000 in MIPS Projects 2Maryland Biotechnology Center Supports $270,000 in MIPS Projects 3Maryland Biotechnology Center Supports $270,000 in MIPS Projects 4Maryland Biotechnology Center Supports $270,000 in MIPS Projects 5InterTech Service to Counter Widely Reported Problems in Automotive, Medical Device and Other Industries Requiring Rigorous Quality Standards 2
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
... and IHC Protocol Development ,Antibody Titer ... in Animal or Human Cells and ... and Tissues ,Peroxidase, Alkaline Phosphatase, Immunogold, ... Electron Microscopy ,Protein Localization in Transgenic ...
Biology Products: