Navigation Links
How the body's energy molecule transmits 3 types of taste to the brain
Date:3/6/2013

PHILADELPHIA Saying that the sense of taste is complicated is an understatement, that it is little understood, even more so. Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now.

A team of investigators from nine institutions discovered how ATP the body's main fuel source is released as the neurotransmitter from sweet, bitter, and umami, or savory, taste bud cells. The CALHM1 channel protein, which spans a taste bud cell's outer membrane to allow ions and molecules in and out, releases ATP to make a neural taste connection. The other two taste types, sour and salt, use different mechanisms to send taste information to the brain.

Kevin Foskett, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania, and colleagues from the Monell Chemical Senses Center, the Feinstein Institute for Medical Research, and others, describe in Nature how ATP release is key to this sensory information path. They found that the calcium homeostasis modulator 1 (CALHM1) protein, recently identified by the Foskett lab as a novel ion channel, is indispensable for taste via release of ATP.

"This is an example of a bona fide ATP ion channel with a clear physiological function," says Foskett. "Now we can connect the molecular dots of sweet and other tastes to the brain."

Taste buds have specialized cells that express G-protein coupled receptors (GPCRs) that bind to taste molecules and initiate a complex chain of molecular events, the final step of which Foskett and collaborators show is the opening of a pore in the cell membrane formed by CALHM1. ATP molecules leave the cell through this pore to alert nearby neurons to continue the signal to the taste centers of the brain. CALHM1 is expressed specifically in sweet, bitter, and umami taste bud cells.

Mice in which CALHM1 proteins are absent, developed by Feinstein's
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Story tips From the Department of Energys Oak Ridge National Laboratory, March 2012
2. First complete full genetic map of promising energy crop
3. Polycrystalline diamond drill bits open up options for geothermal energy
4. NOAA science supports New Yorks offshore energy planning
5. Energy requirements make Antarctic fur seal pups vulnerable to climate change
6. Carnegies Greg Asner named Energy/Climate Fellow by US State Department
7. A new dimension for solar energy
8. Is bioenergy expansion harmful to wildlife?
9. University of Minnesota invention helps advance reliability of alternative energy
10. Nanocrystal-coated fibers might reduce wasted energy
11. Europe meets to discuss progress in energy research and development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How the body's energy molecule transmits 3 types of taste to the brain
(Date:4/15/2014)... cell systems soon could be powering the forklifts used ... and with faster refueling times than ever before, courtesy ... Hydrogen Carriers (HHC). , The goal of the project ... can refuel at low pressure four to five times ... giving hydrogen a competitive advantage over batteries for a ...
(Date:4/14/2014)... It,s a hard pill to swallow, but if you,re ... peak in terms of your cognitive motor performance, according ... SFU,s Joe Thompson, a psychology doctoral student, associate professor ... statistics and actuarial science doctoral student, deliver the news ... , In one of the first social science ...
(Date:4/14/2014)... of whether to get a dog. For families ... even more challenging. Now, a University of Missouri ... of children with autism and found, regardless of ... benefits of dog ownership included companionship, stress relief ... , "Children with autism spectrum disorders often struggle ...
Breaking Biology News(10 mins):Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 3Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 4Study says we're over the hill at 24 2Dog ownership benefits families of children with autism, MU researcher finds 2
... findings with implications for pandemic influenza, a new study reports ... influenza virus can spread from poultry to humans. The ... of Infectious Diseases, now available online. , Crossing the species ... flu virus with pandemic potential. Previous studies have focused on ...
... folklore, Polynesians originated from a mythical homeland called Hawaiki. ... however, have been the subject of much speculation. In ... PLoS Biology, Jean Trejaut and colleagues now provide the ... and indigenous Taiwanese. , Genetic techniques involving mitochondrial DNA ...
... pandemic influenza, a new study reports for the first time ... from poultry to humans. The research appears in the ... available online. , Crossing the species barrier is an important ... potential. Previous studies have focused on the ability of highly ...
Cached Biology News:Transplanting Animal Organs Could Soon Be A Reality 2High-Throughput GoMiner 2Less virulent strains of avian influenza can infect humans 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... If you're on the Midwest technology job market today, ... You've also learned something about interviewing, thank-you letters and ... ,If youre an older job seeker, though, you may ... to surmount your search: your age. Wait. Isn't age ...
... the weeks since, I've been asked many times why the ... of course, one very practical reason: No compelling new services ... that's the easy out. , ,As I've written before, social ... a clear avenue to revenue that returns value to customers ...
... Wisconsin-based businesses and organizations have formed a unique ... efforts of the Medical College of Wisconsin Research ... commercialization activities. The foundation announced the funding along ... Marketing and Licensing, whose primary purpose will be ...
Cached Biology Technology:How 40-plus tech job seekers can prevent age discrimination 2How 40-plus tech job seekers can prevent age discrimination 3How 40-plus tech job seekers can prevent age discrimination 4Social Networks Revisited 2Social Networks Revisited 3Medical College gets support to expand technology commercialization 2Medical College gets support to expand technology commercialization 3Medical College gets support to expand technology commercialization 4
... Combining linear motor and ballscrew ... pre-engineered Cartesian solutions that include ... management, and motors., , ... Pass through high-flex cabling for ...
UGT1A6 (D-20)...
... T Squareds patented high efficiency dynamic valve ... With the most compact, lightweight package in ... use in portable air and gas applications., ... high efficiency. , Includes DC Motor. ...
... designed for moving loads quickly and accurately. ... output while limiting overall size. The P5S-P ... ball bearings guided on two rails., ... provide energy absorption and controlled deceleration , ...
Biology Products: