Navigation Links
How the Parkin enzyme inhibits neuronal cell death
Date:12/18/2013

Cell biologists at the Ruhr-Universitt Bochum (RUB) have launched a new project to unravel the role of the enzyme Parkin in promoting neuronal survival. The team of Prof Dr Konstanze F. Winklhofer from the Institute of Physiological Chemistry, Department of Molecular Cell Biology, is looking for new therapeutic options to treat Parkinson's disease. The Michael J. Fox Foundation finances this research project with 125,000 US Dollars.

Parkin activates a signal pathway that protects neurons

Parkinson's disease is characterized by the degeneration of neurons that produce the neurotransmitter dopamine. In some cases, mutations in the Parkin gene are the underlying cause of this disease. The RUB researchers have recently discovered that Parkin regulates a signal pathway that protects neurons under cellular stress from damage. When the integrity of mitochondria, the cell's powerhouses, is impaired, Parkin is recruited to a protein complex called LUBAC (linear ubiquitin chain assembly complex) and increases its activity. A signal pathway is then activated that leads to the increased expression of protective factors, thus preventing cell death. The RUB team investigates the molecular mechanism of how parkin activates LUBAC and which other regulators play a role in this process. The goal of the project is to identify novel targets to halt or delay the neurodegenerative process in Parkinson's disease.


'/>"/>
Contact: Dr. Konstanze Winklhofer
konstanze.winklhofer@rub.de
49-234-322-2428
Ruhr-University Bochum
Source:Eurekalert

Page: 1

Related biology news :

1. Investigating the link between Parkinsons and pesticides
2. Genetic mutation increases risk of Parkinsons disease from pesticides
3. Gene-silencing study finds new targets for Parkinsons disease
4. UCLA, Emory researchers find a chemical signature for fast form of Parkinsons
5. Why psychosis is frequently associated with Parkinsons disease?
6. Lasers might be the cure for brain diseases such as Alzheimers and Parkinsons
7. Absence of the SMG1 protein could contribute to Parkinsons and other neurological disorders
8. Rare childhood disease may hold clues to treating Alzheimers and Parkinsons
9. PD map: Putting together the pieces of the Parkinsons puzzle
10. Garvan Institute receives grant to research role of long non-coding RNAs in Parkinsons disease
11. Mild cognitive impairment in Parkinsons disease may be linked with extensive neurodegeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... , Jan. 6, 2017  Privately-held CalciMedica, Inc., ... in healthy volunteers of a novel calcium release-activated ... acute pancreatitis. Acute pancreatitis, sudden ... mild disorder, but can be very serious.  In severe ... sepsis, where extended hospital stays, time in the ...
(Date:1/4/2017)... , Jan. 4, 2017  CES 2017 – ... sensor technology, today announced the launch of two ... systems, the highly-accurate biometric sensor modules that incorporate ... technology, experience and expertise. The two new designs ... specifically for hearables, and Benchmark BW2.0, a 2-LED ...
(Date:12/20/2016)... Dec. 20, 2016 The rising popularity ... and leasing is stoking significant interest in keyless ... technology, Bluetooth low energy (BLE), biometrics and near-field ... next wave of wireless technologies in the automotive ... to advanced access systems opens the market to ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... Wells, CA (PRWEB) , ... January 21, 2017 ... ... in our ongoing endeavors to bring to market a pioneering medical device for ... O’Rourke, has signed an engagement contract with Emergo, a global regulatory consultancy that ...
(Date:1/21/2017)... 21, 2017   Boston Biomedical , an industry ... target cancer stemness pathways, today presented data from two ... the 2017 American Society of Clinical Oncology (ASCO) Gastrointestinal ... In a Phase Ib/II study of ... inhibit cancer stemness pathways by targeting STAT3 – colorectal ...
(Date:1/20/2017)... , January 20, 2017 ... cancer is one of leading causes of death worldwide. ... Although the number of cancer related deaths increased gradually ... Rising in incidence rate of various cancers continues to ... a research report by Global Market Insights, Inc. cancer ...
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
Breaking Biology Technology: