A powerful new tool that can help advance the genetic engineering of "fuel" crops for clean, green and renewable bioenergy, has been developed by researchers with the U.S. Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI), a multi-institutional partnership led by Lawrence Berkeley National Laboratory (Berkeley Lab). The JBEI researchers have developed an assay that enables scientists to identify and characterize the function of nucleotide sugar transporters, critical components in the biosynthesis of plant cell walls.
"Our unique assay enabled us to analyze nucleotide sugar transporter activities in Arabidopsis and characterize a family of six nucleotide sugar transporters that has never before been described," says Henrik Scheller, the leader of JBEI's Feedstocks Division and a leading authority on cell wall biosynthesis. "Our method should enable rapid progress to be made in determining the functional role of nucleotide sugar transporters in plants and other organisms, which is very important for the metabolic engineering of cell walls."
Scheller is the corresponding author, along with Ariel Orellana at the Universidad Andrs Bello, Santiago, Chile, of a paper describing this research in the Proceedings of the National Academy of Sciences (PNAS). The paper is titled "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter family of Arabidopsis." The lead authors are Carsten Rautengarten and Berit Ebert, both of whom hold appointments with JBEI, and both of whom, like Scheller, also hold appointments with Berkeley Lab's Physical Biosciences Division. (See below for the full list of co-authors.)
The sugars in plant biomass represent an enormous potential source of environmentally benign energy if they can be converted into transportation fuels gasoline, diesel and jet fuel in a manner that is economically competitive with petroleum-based fuels. One of the keys to success in thi
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DOE/Lawrence Berkeley National Laboratory