Navigation Links
How sperm get into the zona
Date:6/16/2014

Before it can fertilize an egg, a sperm has to bind to and bore through an outer egg layer known as the zona pellucida. Despite decades of research, some of the biological mechanisms behind this process remain unclear. A study in The Journal of Cell Biology now identifies the protein in the zona pellucida that sperm latch onto.

The zona pellucida protects the egg and the early embryo before implantation. Its structure seems simplein humans it contains four kinds of glycoproteins, and in mice it only contains three. But researchers haven't been able to identify the sperm's binding partner in the layer, although their suspicions have fallen on two of the glycoproteins, ZP2 and ZP3.

To find out more, Jurrien Dean and colleagues from the National Institute of Diabetes and Digestive and Kidney Diseases engineered mice to produce various combinations of human and mouse zona pellucida glycoproteins. Mouse sperm didn't bind to the zona pellucida if it was missing ZP2, and female mice lacking the protein were sterile. The researchers also found that sperm couldn't latch onto eggs if ZP2 was missing a key region at the beginning of the protein. This result jibes with a previous finding that fertilization triggers the release of an enzyme that severs ZP2 in this region, thus preventing additional sperm from attaching to the zona pellucida.

The team also tested the binding of human sperm to mouse eggs surrounded by a zona pellucida harboring human glycoproteins. Human sperm adhered to the mouse zona pellucida if it contained human ZP2 but not if it carried human ZP3, confirming the importance of ZP2.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Sperm can count
2. Gene involved in sperm-to-egg binding is key to fertility in mammals
3. Nutrition tied to improved sperm DNA quality in older men
4. Sperm length variation is not a good sign for fertility
5. Fitness for toad sperm: The secret is to mate frequently
6. Insight into DNA reprogramming during egg and sperm cell development
7. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
8. Improving survival of pig sperm
9. Sex chromosome shocker: The female X a key contributor to sperm production
10. First 3-D movies of living sperm
11. How developing sperm stick to the right path
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How sperm get into the zona
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 22, 2017 , ... AESKU.GROUP, an innovation leader in ... Technologien GmbH, thereby expanding its product portfolio to include allergy and food intolerance ... atopic eczema or a food allergy. Allergies are escalating to epidemic proportions and ...
(Date:6/22/2017)... ... 2017 , ... The first human cell line HeLa, established in 1951, has ... cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination and ... and is associated with dramatic consequences for research. , In this educational webinar, ...
(Date:6/20/2017)... ... ... Biologist Dawn Maslar MS has found a biomarker that she claims verifies ... The Neuroscience of Meeting, Dating, Losing Your Mind, and Finding True Love, Maslar found ... step, in my estimation, was to scientifically track the evidence of commitment in men,” ...
(Date:6/20/2017)... ... June 20, 2017 , ... Do More with OHAUS , With the ... trusted supplier in the weighing industry, to extending its expertise across the entire laboratory ... immunoassays, hybridizations and more, allowing for its customers to 'Do More' in ...
Breaking Biology Technology: