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How protein networks stabilize muscle fibers: Same mechanism as for DNA
Date:1/23/2012

ins Linke. "Precisely this elastic region of titin is protected by the association with methylated Hsp90."

Titin requires protection by methylated proteins

In skeletal muscle cells of the zebrafish, Linke's team explored what happens when the protection by the methylated heat shock protein is repressed. By genetic manipulation they altered the organism in such a way that it no longer produced the enzyme Smyd2, which blocked the methylation of Hsp90. Without methylated Hsp90, the elastic titin region was unstable and muscle function strongly impaired; the regular muscle structure was partially disrupted.


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Contact: Dr. Wolfgang Linke
wolfgang.linke@rub.de
49-234-322-9101
Ruhr-University Bochum
Source:Eurekalert

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