Navigation Links
How our cells cope with toxic small molecules
Date:1/30/2013

In this week's issue of the prestigious journal Nature Chemical Biology, scientists Carole Linster (University of Luxembourg), Emile Van Schaftingen (Louvain University), and Andrew D. Hanson (University of Florida, Gainesville) review an important, but so far neglected, part of metabolism, namely metabolite damage-control. In their publication 'Metabolite damage and its repair or pre-emption', the authors present a comprehensive overview of the known reactions generating unwanted small molecules in the cell as well as of the corresponding control mechanisms, and discuss the importance of this 'quality control' for cellular and organismal health.

"Damage-control in metabolism represents an entirely new concept, that shifts our view from linear metabolic pathways sustained by highly specific enzymes to more complex networks that take into account numerous damage and repair reactions", explains Dr. Carole Linster, a young group leader at the Luxembourg Centre for Systems Biomedicine (LCSB), and hopes that her and others new research findings will lead to a change of paradigm in metabolism.

The molecules that constitute living cells are constantly subject to damaging reactions and fixing this damage immediately is crucial for cellular health and survival. Damage-control must therefore have existed since the dawn of life, and the repair mechanisms that cells have adopted throughout evolution have been studied by scientists for decades. But until recently, most researchers have focused their attention on the repair mechanisms acting on large molecules such as DNA and proteins, while damage-control of small molecules, called metabolites, has mostly been overlooked. Linster explains this oversight: "Classical biochemistry taught us that, given the high substrate specificity of enzymes, metabolic reactions are very precise processes which don't generate any useless or toxic by-products. But thanks to new technologies we have learned that this is not the case, and that the cell is likely to constantly produce damaged metabolites, which have to be eliminated or repaired." A deficiency in metabolite repair can lead to fatal disease in humans.

The field of 'metabolite damage-control' is still in its infancy and biochemists are just starting to understand how the cell repairs damaged metabolites. This suggests that many metabolite damage-control systems remain to be discovered. "I hope that scientists who read this review will be convinced that metabolite repair is an important aspect of cell metabolism", says Linster. "It should inspire researchers to look for yet unidentified reactions and thereby improve our understanding of the extent of metabolite damage-control and the physiological importance thereof."


'/>"/>
Contact: Carole Linster
carole.linster@uni.lu
003-524-666-446-231
University of Luxembourg
Source:Eurekalert

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems is ... log work hours, for employers to make sure the right employees are actually signing ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita ... miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject of ... now. , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... 23, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... Laboratory, has joined STACS DNA as a Field Application Specialist. , “I am ... and COO of STACS DNA. “In further expanding our capacity as a scientific integrator, ...
Breaking Biology Technology: