Navigation Links
How our cells cope with toxic small molecules
Date:1/30/2013

In this week's issue of the prestigious journal Nature Chemical Biology, scientists Carole Linster (University of Luxembourg), Emile Van Schaftingen (Louvain University), and Andrew D. Hanson (University of Florida, Gainesville) review an important, but so far neglected, part of metabolism, namely metabolite damage-control. In their publication 'Metabolite damage and its repair or pre-emption', the authors present a comprehensive overview of the known reactions generating unwanted small molecules in the cell as well as of the corresponding control mechanisms, and discuss the importance of this 'quality control' for cellular and organismal health.

"Damage-control in metabolism represents an entirely new concept, that shifts our view from linear metabolic pathways sustained by highly specific enzymes to more complex networks that take into account numerous damage and repair reactions", explains Dr. Carole Linster, a young group leader at the Luxembourg Centre for Systems Biomedicine (LCSB), and hopes that her and others new research findings will lead to a change of paradigm in metabolism.

The molecules that constitute living cells are constantly subject to damaging reactions and fixing this damage immediately is crucial for cellular health and survival. Damage-control must therefore have existed since the dawn of life, and the repair mechanisms that cells have adopted throughout evolution have been studied by scientists for decades. But until recently, most researchers have focused their attention on the repair mechanisms acting on large molecules such as DNA and proteins, while damage-control of small molecules, called metabolites, has mostly been overlooked. Linster explains this oversight: "Classical biochemistry taught us that, given the high substrate specificity of enzymes, metabolic reactions are very precise processes which don't generate any useless or toxic by-products. But thanks to new technologies we have learned that this i
'/>"/>

Contact: Carole Linster
carole.linster@uni.lu
003-524-666-446-231
University of Luxembourg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... captive black rhino reproduction in Europe highlights how ... programmes. , Researchers from Chester Zoo, The University ... out a six-year study which encompassed 90% of ... Edwards led the research as part of her ... "Although some black rhinoceros breed well in captivity, ...
(Date:8/22/2014)... CAEveryone,s heard of the birds and the bees. ... that are being fertilized. The fertilization process for ... communication between the male and female reproductive cells. ... Regensburg, Heidelberg, and Munich, and including Carnegie,s Wolf ... in the chemical signaling process that guides flowering ...
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. ... growing mobile commerce market, announced today that its shares ... stock to be issued in its proposed underwritten public ... for listing on The Nasdaq Capital Market, subject to ... common stock and warrants, and will trade under the ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Calcium and reproduction go together 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... A research team led by LSU Associate Professors of Biological ... of a combined field and laboratory study showing the effects ... Louisiana marshes. , The study, funded in part ... of Mexico Research Initiative is being published in the journal ...
... ... Presidential Early Career Award for Scientists and Engineers (PECASE). The award ... scientists and engineers in the early stages of their careers. ... significant award," said Jane Lubchenco, Ph.D., under secretary of commerce for ...
... , ASHEVILLE, NC A recent analysis of two ... (FIA) data shows the live volume of hemlocks in ... of hemlock woolly adelgid. FIA scientists from the Forest ... (NRS) published the information as an SRS e-Science Update ...
Cached Biology News:LSU researchers find impact of oil spill in marsh fish species 2President to honor high achieving, early career NOAA scientists 2Hemlocks still abundant despite adelgid infestations 2
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
(Date:8/22/2014)... “Our nation's healthcare system is broken, ... Furthermore, every governmental and professional entity that has ... of unorganized dysfunction shares in that enormous blame. ... as a device to use in an effort ... have accumulated through the years leading to the ...
(Date:8/21/2014)... Hershey, PA & Rockville, MD (PRWEB) August 21, 2014 ... Inc. (ITI) is making progress in its development ... allergy to Japanese red cedar pollen. Phase IC studies ... to a real solution to hay fever. , The ... in over 35 million people in Japan. Mountain Cedar ...
(Date:8/21/2014)... including DESY scientists has observed tiny quantum vortices in ... the journal Science that the exotic vortices ... It is the first time that the quantum vortices, ... what is known as superfluid helium, have been detected ... says Andrey Vilesov of the University of Southern California, ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Scientists observe quantum vortices in cold helium droplets 2
... - 11:00 a.m. ET; 8:00 a.m. PT, VANCOUVER ... (TSX: MGI; OTC: MGIFF), a clinical-stage developer of drugs ... on Tuesday,September 11, 2007 at 11:00 a.m. ET (8:00 ... quarter ended July 31, 2007. An update on,company activities ...
... Keynote Emphasizes Generic Industry Readiness and Questions Fiscal ... Social Responsibility of Delaying Biogenerics -, WASHINGTON, Sept. ... crossroads as decades-old patents,expire, and generic companies stand ready ... time to pass legislation enabling the U.S.,Food and Drug ...
... Sept. 6 NPS,Pharmaceuticals, Inc. (Nasdaq: NPSP ) ... for any and all of its outstanding 3.0% Convertible,Notes ... Eastern Time on,October 4, 2007, unless extended. The tender ... and the related letter of transmittal, is not,subject to ...
Cached Biology Technology:MIGENIX First Fiscal Quarter 2008 Financial Results Conference Call & Webcast Notification 2Biogenerics Will Save Billions, Says Hospira CEO 2Biogenerics Will Save Billions, Says Hospira CEO 3Biogenerics Will Save Billions, Says Hospira CEO 4NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 2NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 3NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 4
...
... ISOQUANT(R) Isoaspartate Detection Kit is intended for ... proteins and peptides, which can result from ... rearrangement of aspartic acid residues during storage ... depend on the monitoring of charge differences ...
...
...
Biology Products: