Navigation Links
How muscle develops: A dance of cellular skeletons
Date:6/3/2011

from being capped by proteins that prevent further actin growth. Apart from its protective role, WASP also has to come off the end of the actin filaments from time to time to start new actin branches. The intricate balance between actin filament growth, capping and branching, determines the dynamics of the cytoskeleton. Armed with this knowledge, the researchers tested whether Blown Fuse competes with this process to change how WASP simultaneously protects and builds the cytoskeleton.

The test began with researchers putting fluorescent actin in fruit fly muscle cells that incorporated themselves into the growing actin branches in the finger-like protrusions. Then, the researchers used a laser beam to bleach the fluorescent actin in the region of the finger-like protrusions and waited to see whether and how long it would take for new, unbleached actin to spread from other parts of the cell and be taken up by the growing branches in the "fingers." In normal muscle cells, it took about two minutes for the fluorescence to return. In muscle cells that lacked Blown Fuse, the fluorescence never fully recovered and the cytoskeleton failed to project finger-like protrusions, probably because the WASP-WIP complex does not come off the ends of the actin filaments to start new actin branches.

"These results suggest that the growing ends of the actin cytoskeleton are occupied by the WASP-WIP protein duo and that without Blown Fuse to dissociate with the WASP-WIP complex and push WASP off the ends, new actin branches cannot be started," says Chen. "And these shorter and stiffer new branches are critical for generating the finger-like membrane protrusions."

Through a microscope, the Hopkins team compared the finger-like projections from normal cells with cells lacking Blown Fuse. Normal muscle cells form pointy finger-like protrusions that push into the other muscle cell, but cells without Blown Fuse have fewer and floppier protrusions that don't push t
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
2. Women do not recover their muscle strength as fast as men
3. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
4. Stabilizing force for good communication between neurons and muscle cells found
5. Mediator in communication between neurons and muscle cells found
6. MSU researcher studies ties between cholesterol drugs, muscle problems
7. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
8. First trial in patients with a potential treatment of the incurable ALS muscle disease
9. Motor nerve targeting to limb muscles is controlled by ephrin proteins
10. Study links molecule to muscle maturation, muscle cancer
11. Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... --  LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ... bring LaunchKey to market in 2015. LaunchKey ...
(Date:12/17/2014)... 15, 2014 The Defense Logistics Agency ... to detect and prevent counterfeit microcircuits from entering ... agency started performing an in-house microcircuit anti-counterfeit initiative ... authenticity of purchased microcircuits while increasing their reliability ... measures will be conducted at DLA,s Electronics Product ...
(Date:12/17/2014)... -- Valencell, a leader in performance biometric data sensor ... leaders such as Intel, Jabra, Atlas, and Scosche to ... These products will be showcased at CES 2015, taking ... . "Our partners choose PerformTek biometrics, ... with the clinical data to back it up," said ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... Nautiloids are the sole surviving family of externally-shelled ... million years ago. However, in the intervening years ... and developed complex central nervous systems; which makes ... that led to the development of the complex ...
... Micro gyro . . . Airplanes, submarines ... arrays of inexpensive high-performance micro-mechanical gyroscopes for navigation and ... being developed by a team consisting of Panos Datskos, ... Laboratory is radically different than today,s gyroscopes, which are ...
... highly developed emotional sensibilities are better at making product ... of Consumer Research. "Consumers who understand their emotional ... health decisions and product choices," explain the authors, Blair ... of Kentucky). "A person can know a lot about ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2008 3
(Date:12/24/2014)... 24, 2014  United Therapeutics Corporation (NASDAQ: ... (NYSE: MDT ) has submitted a ... Drug Administration (FDA) for the use of Medtronic,s ... (including a newly developed catheter) for use with ... intravenously to patients with pulmonary arterial hypertension.   ...
(Date:12/24/2014)... GMO corn cases filed across the ... in the process of being consolidated in a Kansas ... In Re: Syngenta AG MIR 162 Corn Litigation, MDL ... District of Kansas. , Management of the Syngenta GMO ... U.S. District Judge John W. Lungstrum.* , As a ...
(Date:12/24/2014)... The report provides basic ... definition, classification, application and industry overview. This ... and product cost structure. Production is separated ... also covers upstream raw materials, equipment, downstream ... and proposals. In the end, the export ...
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... - In Wisconsin, there is a growing belief that ... the loss of local ownership inevitably harms the state's economy. ... Corp . by Illinois-based CDW Corp . has a ... to those closest to the deal. , ,The win-win view ...
... expiring patents, generic drugs, and increasing costs of ... are increasingly turning to innovative biotechnology companies to ... business opportunities. , ,At a recent meeting of ... , pharmaceutical company representatives from Astellas Pharma, ...
... second consecutive year, the City of Madison received ... municipalities in the country. , ,In its 2006 Digital ... national research and advisory institute on information technology and best ... the top user of technology in its 125,000-249,999 population category. ...
Cached Biology Technology:Anatomy of a deal: CDW and Berbee 2Anatomy of a deal: CDW and Berbee 3Anatomy of a deal: CDW and Berbee 4Big pharma seeks Wisconsin biotech partnerships 2
...
... Peptide-Protein Conjugation, ... Bridges, Complex Peptides/Peptidomimetics, Special ... Phosphorylated/Biotinylated Structures, Peptide labeling AMC, ... -99%, fitting your needs, Chromogenic/Flurogenic ...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
...
Biology Products: