The current study, conducted by Dr. Ariel alongside a team of students led by Dr. Sagie Schif-Zuck, set out to probe the critical stage of the healing process, when the macrophages decide to relocate and adjust their healing activities, moving from local rehabilitation of the damaged tissue to shut down of systemic immune responses at organs of the immune system.
The researchers discovered that the macrophages have a fascinating "uptake threshold" of seven cells. After engulfing seven neutrophils they are "licensed" to leave the tissue and continue with their remote tasks. The research also found that these cells are sensitive to the tissue's healing pace, so that when the tissue is healing quicker, they are permitted to leave earlier, and when the tissue is finding it harder to repair itself, they hang around longer, even after reaching the uptake threshold of seven cells. The researchers also discovered substances that "inform" the cells on the tissue's rate of repair, and found that by injecting these substances, the macrophages' transition to immune organs is accelerated while new macrophages are recruited to further treat the damaged tissue and continue the healing process. In addition, the study revealed that as they leave the tissue, the macrophages undergo molecular changes necessary to carry out their new functions in the lymphatic system.
"Our new study has found a major event in the inflammatory healing process that is responsible for the transition of macrophages from local rehabilitation of the damaged tissue to its consequent role in promoting the immune system's return to routine. The findings from our study can assist in the dev
|Contact: Rachel Feldman|
University of Haifa